基于D-H法的隧道锚杆安装机械手机构设计

为解决隧道锚杆安装过程中效率低、阻力大、不易完全装入等问题,采用D-H法建立锚杆安装机械手坐标系。通过对机械手结构的齐次坐标变换建立机械手运动学方程,并结合工程施工参数,得出推进机构运动与机械手爪运动之间的关系,理论计算出锚杆安装机械手相关设计参数,从而设计一种新型的隧道锚杆安装机械手。该机械手安装速度为38.9 mm/s,与传统钻杆推进安装方式相比,单循环节约工时约2 h,经济优势突出。     

临江高承压水超深基坑支护方案研究

文章依托福州市地铁2号线厚庭站-桔园洲站区间风井,对临江高承压水超深基坑支护方案的设计思路进行阐述。为解决临江高承压水超深基坑支护结构受力与变形、开挖实施方案及施工工序等方面问题,采用数值模拟与现场实测结果相结合的方法对基坑支护方案进行分析。风井基坑的理论及实测结果表明： 对开挖深度大、承压含水层厚而导致隔水帷幕难以穿透承压含水层的基坑工程,可将基坑开挖方式分为常规的隔水干开挖和水下开挖结合的形式,其中水下开挖可有效防止基底突涌的发生,同时改善支护结构的受力与变形;设计中需重点关注水下开挖阶段支撑体系受拉、受扭等不利工况;水下封底素混凝土板是抵抗坑底巨大承压水压力的有力保障,是确保工程实施的关键措施,其受力状态主要表现为受弯和受剪。     

辽宁资源城市接续发展的产品市场战略

辽宁是东北老工业基地振兴的龙头,而辽宁资源城市接续发展问题是制约辽宁发展的一个规颈.本文以SWOT矩阵为工具,从战略管理营销的产品市场战略角度探讨辽宁资源城市接续发展问题.     

曲梁位移场函数的单元刚度矩阵和一致质量矩阵

以多项式作位移场的曲梁有限元单元模型因薄膜力闭锁和剪力闭锁而存有误差。基于满足边界约束条件的曲梁位移场函数的单元刚度矩阵和一致质量矩阵,经自编程序与某商业大型计算软件验证,其精度良好,对实际工程有一定的指导和借鉴意义。     

公共危机管理中地方政府虚假治理的逻辑——一种基于委托-代理理论的解释

地方政府与上级政府和地方民众之间的关系具有委托——代理性质。以委托——代理模型为基础,通过建立作为代理人的地方政府在处置公共危机过程中的支付矩阵,可以更清楚地分析地方政府作为代理人的各种策略选择,从而有力地解释地方政府在公共危机管理中虚假治理的原因。     

环氧氯丙烷对组织工程心脏瓣膜构建中基质金属蛋白酶1、3表达的影响

目的探讨环氧氯丙烷对组织工程心脏瓣膜构建中基质金属蛋白酶-1、3(matrix metalloproteinase-13、,MMP-1、3)表达的影响。方法采用去垢剂和胰蛋白酶消化制备的脱细胞猪主动脉瓣膜支架作为对照组,用30 g/L环氧氯丙烷处理24 h的去细胞支架材料作为实验组。将培养的人骨髓间充质干细胞(human bone marrow mesenchymalstem cells,hBMSCs)种植于脱细胞支架上的组织工程心脏瓣膜(tissue engineering heart valve,TEHV),分别行石蜡包埋切片HE染色和扫描电镜观察TEHV的组织结构,并行RT-PCR测定hBMSCs分泌MMP-1、3的功能。结果hBMSCs在实验组脱细胞瓣膜表面生长良好,MMPs的表达比对照组降低。结论环氧氯丙烷处理的脱细胞猪主动脉瓣膜支架,可以抑制hBMSCs的MMP-1、3的表达。     

组织工程化软骨的构建及应用

"组织工程"(tissue engineering)是上世纪80年代正式提出来的新概念。它是生物医学和材料科学多学科交叉融合的新兴分支学科。近20年来,该学科有了很大的发展,其研究范围也更加广泛。本文结合我们近年的研究成果,着重论述组织工程化软骨的构建及其在软骨损伤和修复研究中的应用。     

The clinical role of increase of serum matrix metalloproteinase-8 concentration in patients with acute coronary syndrome

Objective To study the clinical role of the variation of serum matrix metalloproteinase-8 (MMP-8)concentration in patients with acute coronary syndrome (ACS). Methods ELISA method was adopted to detect serum MMP-8 concentration and to observe concentration's differences and features among 80 selected ACS cases (43 acute myocardial infarction and 37 unstable angina pectoris), 43 stable angina pectoris (SAP) cases and 37 control cases.And meanwhile the atherosclerosis risk factors of each case, such as age, sex, hypertension, body mass index, smoking,family history, diabetes, and hyperlipidemia were collected and analyzed as a whole. Results First, serum MMP-8 concentration reached the highest point in ACS, and there was significant difference between SAP and control groups (P<0.01). Second, sermn MMP-8 in AMI was much higher than that in UAP with significant difference (P<0.01). There was no difference between UAP and SAP groups (P>0.05). Third, Logistic regression analysis revealed that serum MMP-8 concentration might be the indicator of ACS (B=4.493, P=0.000), particularly, that of AMI (B=9.961,P=0.000). Fourth, linear correlation and linear regression analysis found that only neutrophil was likely to influence serum MMP-8 concentration (r=0.274, P=0.001). Fifth, in the diagnosis of ACS, the area under ROC curve of MMP-8 was 0.785, the sensitivity and specificity were 68.6% and 76.5%, respectively. Conclusion ① Serum MMP-8 concentration has close relationship with the occurrence of ACS, particularly with AMI;② Serum MMP-8 concentration may be one of the predicting indicators of ACS and particularly of AMI;③ Neutrophil may be correlated with serum MMP-8 concentration;④ MMP-8 is of somewhat valuable in diagnosing ACS.     

Relationship between the expression of matrix metalloproteinase-9 and angiogenesis in glioma and its clinical significance

Objective To explore the role and significance of matrix metalloproteinase-9 (MMP-9) in angiogenesis through observing the relationship between the expression of MMP-9 and microvessel density (MVD) in glioma. Methods The expressions of MMP-9 and CD34 in 10 cases of normal brain tissues and 58 cases of glioma (14 cases of grade Ⅰ , 20 cases of grade Ⅱ , 15 cases of grade Ⅲ, and 9 cases of grade Ⅳ ) were detected by immunohistochemical streptavidin-peroxidase technique. The positive cells of MMP-9 and the positive microvessels were examined under binocular light microscope. Results The positive expression of MMP-9 in glioma was located in the tumor-cell cytoplast and endothelial cells. The positive rate of MMP-9 in glioma of grade Ⅰ, Ⅱ, Ⅲ and Ⅳ was 42.9%, 65.0%, 86.7% and 88. 9%, respectively. The expression of MMP-9 was obviously higher than that of normal brain tissues (P<0.01) and positively correlated with glioma malignancy (rz =0. 597, P<0.05). MVD was correlated with glioma malignancy (H=47. 865, P<0. 05). The expression of MMP-9 was significantly correlated with MVD (rz =0.897, P<0.01). Conclusion The expressions of MMP-9 and MVD are correlated with glioma malignancy, which may be helpful in judging the malignancy, invasion and prognosis. MMP-9 plays an important role in angiogenesis of glioma and accelerates glioma malignancy development by promoting angiogenesis.     

考虑路段流量不确定性的OD矩阵反推算法

现有OD矩阵反推技术大都将路段流量确定为稳定不变的,导致反推精度不高。为了解决这一问题,以交通网络平衡和双层规划模型为理论基础,选取路段流量与实测流量之间的偏差平方和最小作为目标函数,删除OD矩阵的判别误差函数,将双层规划模型简化为单层规划,从而减少了计算量。以云南省某城市中心城区路网作为实际算例,采取用户平衡分配模型进行验证。结果表明,分配得到的路段流量与实测流量的相对误差都在12％以内,证明该方法与已有研究中以网络行驶时间最小作为目标函数的反推模型相比,精度更高。