AQP4在COPD支气管黏膜的表达及其与患者肺功能、气道黏膜炎症的相关性

目的通过免疫组化法检测支气管黏膜中水通道蛋白-4(aquaporin-4,AQP4)的表达,观察正常组和慢性阻塞性肺疾病(chronic obstructive pulmonary disease,COPD)组支气管黏膜中AQP4表达与气道黏膜炎症及肺功能的关系,明确AQP4在COPD发生、发展中的作用,为COPD的防治开辟新途径。方法选择正常人和COPD患者各30例,测试肺功能,并行支气管镜检查,取得支气管黏膜标本,用免疫组化法检测AQP4表达,HE染色观察支气管黏膜炎症细胞浸润程度。结果COPD组较对照组AQP4表达减弱有极显著差异(P<0.001)。AQP4表达和FEV1/FVC、FEV1/pred%呈正相关(P<0.001),与支气管黏膜炎症严重程度呈负相关(P<0.001)。结论COPD患者AQP4表达减少可能是其肺功能下降及气道炎症加重的原因之一。临床上可以通过改善AQP4治疗COPD。     

高性能混凝土在路面工程中的应用

高性能混凝土是一种新型的高技术混凝土,已经被重要结构工程广泛采用．并在高层建筑、大跨径桥梁等工程中显示出其独特的优越性。“双掺技术”的提出使得普通混凝土路面的路用性能有了明显改善,表现为强度提高、脆性下降,抗冻性和耐磨性均有增强,故这是值得推广的一项新技术。     

中心试验室在质量监理中的作用

中心试验室在工程建设中,注意结合富太线二级公路的实际情况,应用合同条款,开展检测试验工作,在指导、监督、服务上下功夫,强化质量管理,为保证工程质量、加快施工进度、控制工程投资作出了应有的努力,取得了一定的成绩。     

内置肋板补强圆形钢桥墩的抗震性能

采用MARC有限元程序,对内部加肋补强的圆形桥墩柱7个试件进行非线性数值分析.得到了在一定垂直荷载和水平往复荷载作用下荷载-位移关系曲线,考察了钢管径厚比和桥墩柱长细比对内部加肋补强圆形钢桥墩的极限承载能力、延性和能量吸收等抗震性能的影响.     

不同出行距离的客货运量分布研究

根据客货出行的随机性以及组成理论中的最复杂原理,可推导出客货出行距离的概率分布,得出客货出行的规律,从而为交通规划以及运输规划提供依据,同时也为客货出行特性的研究提供新的思路。     

轴流式涡轮机动叶片的叶顶间隙对其气动性能影响

采用数值方法对不同叶顶间隙下某型号船用轴流式涡轮机的气动性能进行了对比分析.结果表明,叶顶间隙对喷嘴环前缘的压力分布和涡轮内的温度分布影响明显,过小和过大的叶顶间隙都会导致喷嘴环前缘高压力区的产生,并导致涡轮内局部高温度区域扩大;随着叶顶间隙的增大,喷嘴环后缘底部、吸力面及叶顶间隙内局部高熵区随之增大,燃气能量损失增大.     

Two Phase Pressure Drop Performance of Refrigerant in a Small Horizontal Smooth Tube with 2.5 mm inside Diameter

Two-phase flow pressure drop measurements were made during the phase change heat transfer process of R22 in a small horizontal smooth tube with 2.5 mm inside diameter. Conclusions can be drawn that the quality corresponding to the pressure gradient peak value of small tubes became higher than that of large tubes. The effect of quality to pressure drop becomes weak as the mass flux increases. The experiment data were compared with the predicated values of the state-of-the-art correlations from the open literature. The comparisons between the data and the predictions indicate that most of the state-of-the-art correlations fails to predict the experimental data.Chisholm model shows a relatively better predictive ability than the other empirical correlations although it has a mean deviation of 26.7%. But the predicated values of Chisholm model are lower by 50% than the experimental data when the quality becomes larger.     

悬臂梁自由端受集中载荷作用考虑几何非线性时的位移函数

针对以往几何非线性悬臂弯曲的位移函数公式繁琐或计算结果误差较大的问题,通过近似并利用加辽金积分推导得出其位移函数.结合具体实例与ANSYS解进行比较,结果表明其吻合较好,说明所提出的位移函数简洁且精度高.     

Reliability Analysis of Excavator Rectifier Feedback System with Multi-State Components Based on Belief Universal Generating Function Method

In view of the complexity and uncertainty of system, both the state performances and state probabilities of multi-state components can be expressed by interval numbers. The belief function theory is used to characterize the uncertainty caused by various factors. A modified Markov model is proposed to obtain the state probabilities of components at any given moment and subsequently the mass function is used to represent the precise belief degree of state probabilities. Based on the primary studies of universal generating function(UGF)method, a belief UGF(BUGF) method is utilized to analyze the reliability and the uncertainty of excavator rectifier feedback system. This paper provides an available method to evaluate the reliability of multi-state systems(MSSs) with interval state performances and state probabilities, and also avoid the interval expansion problem.     

浅谈价值管理在建设工程设计阶段的应用

价值管理研究在设计应用中要达到的重要目的之一就是考虑项目业主的价值取向,对业主强烈持有的价值观的理解.设计过程中引入价值管理研究,可以在设计的最初阶段对设计的本质问题进行探察,鼓励业主和用户对设计方案建立自己的设计和实践理念,以便设计师能从这些观点中获益,在设计过程中使得价值转化为设计因素.