Study on T lymphocyte subsets and NK cells in patients with Graves＇ disease combined with type 2 diabetes

Objective To investigate changes in T lymphocyte subsets and NK cells in patients with simple Graves' disease (GD)and Graves' disease combined with type 2 diabetes mellitus (GD/T2DM). Methods Fifteen cases of GD/ T2DM were selected from our hospital from November 2001 to November 2004. Before and after therapy thyroid function, thyroglobulin antibody (TGA), thyroid microsomal antibody (TMA) and blood glucose level were measured, and T lymphocyte subsets (CD3, CD4, CD8, CD4/CD8) and NK cells (CD56) were measured by immunofluorescence double labeling monoclonal antibody and flow cytometry, respectively. At the same time, comparison was made with simple GD (15 cases), T2DM (15 cases) and healthy control (20 cases). Results Before therapy, CD4/CD8, CD4 and NK cells in GD/T2DM were less than normal, and there was no significant difference in comparison with simple GD (P<0.05). In T2DM group, only CD4/CD8 and CD4 were less than those of healthy controls (P<0.05). When thyroid function recovered after 1 to 3 months of methimazole treatment in both GD/T2DM and simple GD groups, various indexes recovered, which were more obvious in simple GD. Conclusion Immune hypofunction of GD may be the key to the immune abnormality of GD/T2DM, which is more significant than that of simple GD or T2DM. The recovery of thyroid function and immune abnormality is not consistent, and the recovery of GD is more significant than that of GD/T2DM.     

2型糖尿病患者一级亲属正常糖代谢人群胰岛素抵抗分析

目的探讨2型糖尿病(T2DM)患者糖耐量正常的一级亲属胰岛β细胞功能及胰岛素抵抗情况,并分析胰岛素抵抗的相关因素。方法选取T2DM患者糖耐量正常的一级亲属63例,根据胰岛素抵抗指数分为胰岛素抵抗组及非抵抗组;选取30例健康体检者作为正常对照组。对所选的93例对象进行血压、血糖、胰岛素、血脂的测定,并计算稳态模型胰岛素抵抗指数(HOMA-IR)及胰岛β细胞功能指数(HOMA-β)。结果①糖尿病患者一级亲属组与对照组相比,胰岛素水平、HOMA-IR、HOMA-β明显升高(P<0.05);②胰岛素抵抗组体质指数、舒张压、甘油三酯、餐后血糖、HOMA-β明显高于胰岛素非抵抗组(P<0.05);③相关分析示胰岛素抵抗与体质指数、舒张压、甘油三酯、餐后胰岛素呈正相关(P<0.01,P<0.05),与空腹血糖、餐后血糖、空腹胰岛素、收缩压、胆固醇无显著相关性(P>0.05)。结论T2DM患者一级亲属存在胰岛β细胞代偿性的高分泌,早期已经出现胰岛素敏感性的下降和胰岛素抵抗。胰岛素抵抗与体重增加、舒张压升高及甘油三酯的升高有关。提示对糖尿病患者一级亲属应严格控制体重、血压及血脂,对减少T2DM具有积极意义。     

两种大型集装箱船绑扎桥结构强度的对比计算浅析

以大型集装箱船常见的剪力墙式绑扎桥和A型斜撑式绑扎桥为研究对象,基于通用大型有限元分析软件PATRAN/NASTRAN及CCS规范的相关要求,对两种绑扎桥的结构强度进行了对比计算分析。结果表明：两种型式的绑扎桥在结构强度方面相差不大,相比而言,剪力墙式绑扎桥略优于A型斜撑式。     

浅滩区桥梁基础施工工艺

武汉二七长江大桥北岸6 m×90 m副通航孔桥段位于长江Ⅲ级阶地,施工期水文地质情况变化剧烈,预定的钢套箱法基础施工工艺适应性受到了严重影响。基于对浅滩区桥梁基础施工常用围堰形式特点、适用性的分析,结合该工程实际,将基础施工工艺调整为钢板桩围堰法,达到提高施工效率、节约成本的目的。     

在役港工混凝土强度时变规律

钢筋混凝土构件是港口码头结构中的主要组成部分,研究其构件在服役一段时间后混凝土强度的分布特征以及时变规律具有重要的实际意义。对大量混凝土强度的检测数据进行统计分析,采用W检验法对混凝土强度进行了概率分布类型的拟合检验,验证了采用正态分布的可行性,并给出了采用不同检测方法混凝土强度的参考值;通过统计不同年限混凝土强度的实测值,采用回归分析的方法得到回弹法测得的混凝土强度值与服役年限之间的关系。     

干涉对海洋立管涡激振动影响实验研究

文章进行了干涉对海洋立管涡激振动影响的实验研究,实验分为立管前后排列和并肩排列两部分。立管间距为3~10倍直径,模型材料采用有机玻璃,长1.5 m,外径18 mm,壁厚2 mm,边界条件均为铰接,外流速分别从0.3~0.8 m/s,每级增加0.1 m/s。通过在立管表面粘贴应变计获得动态应变数据,分别从立管的横向动态响应、振幅、频率等方面对前后排列、并肩排列立管以及和单独立管的实验数据进行对比研究。结果表明,当有外流通过时,立管会受到其他立管尾流的影响,漩涡脱落引起的振动由于间距及排列方式的不同而显著不同,使得立管的动力特性、动力响应以及漩涡的脱落形式同单个立管相比均有较大的变化。     

大功率车载取力自发电系统结构研究

为充分解决装备野外环境下电源保障问题,为系统中的设备提供不低于80 kW供电电源,对比了两种供电技术方案,择优确定80 kW车载取力发电的供电形式;为保证动力输出,采用分动器取力;为保证布局的紧凑性,采用二级传动形式,通过传动轴传动和同步带传动的组合传动模式实现动力传递;电机安装平台采用铰接调整式结构,实现传动带的松紧...     

高桩码头维护检测有关问题的探讨

指出了目前对高桩码头维护、检测的必要性和迫切性 ,并对码头结构的破损类型、检测的内容及方法、评估的途径进行了较详细的探讨 ,同时还提出了检测周期的建议。     

大型无底空心块体结构在南油水泥建材码头中的应用

简要介绍大型无底空心块体结构在南油水泥建材码头中的设计概况和施工技术要点。     

Evaluation of pedestrian crosswalk level of service (LOS) in perspective of type of land-use

In India pedestrians usually cross the road at mid-block crosswalks due to ease of access to their destination or the development of adjacent land use types such as shopping, business areas, school and residential areas. The behaviour of pedestrian will change with respect to different land use type and this change in behaviour of pedestrian further reflects change in perceived level of service (LOS). So, it is important to evaluate the quality of service of such crossing facilities with respect to different land-use type under mixed traffic conditions. In this framework, pedestrian perceived LOS were collected with respect to different land-use type such as shopping, residential and business areas. The ordered probit (OP) model was developed by using NLOGIT software package, with number of vehicles encountered, road crossing difficulty as well as safety considered as primary factors along with pedestrian individual factors (gender and age), land-use type and roadway geometry. From the model results, it has been concluded that perceived safety, crossing difficulty, land-use condition, number of vehicles encountered, median width and number of lanes have significant effect on pedestrian perceived LOS at unprotected (un-signalized) mid-block crosswalks in mixed traffic scenario. The inferences of these results highlights the importance of land use planning in designing a new set of pedestrian access facilities for unprotected mid-block crosswalks under mixed traffic conditions. Also the study results would be useful for evaluating pedestrian accessibility taking into account different land-use type and planning required degree of segregation with vehicular movement at unprotected mid-block crosswalk locations.