“城市双修”理念在道路改造工程中的应用

以淄博市金晶大道改造工程为工程实例,通过分析现状道路存在的问题,结合国家相关政策,在道路改造过程中贯彻了"城市双修"的设计理念。在道路实施过程中,通过建设公交专用道、新建慢行一体路面、改造店前铺装、建设停车位、完善交通设施等措施以完善城市功能,通过建设绿化带、透水路面等措施,改善行道树的生存环境,实现生态修复。     

基于物流运输保障的仓储管理效率分析

物流企业实施仓储管理的一个重要目标是为市场的实际需求提供切实的物流运输保障.从物流企业仓储管理的现状入手,结合实际对仓储管理的效率进行了层次模型分析,构建了以仓储管理效率为理念的仓储管理方法.     

冷铺沥青材料的特性与配制技术

用冷铺沥青混合料修补路面坑洞,具有方便、快捷等优点.为保证其疏松性和压实性,在配制方法上,如所用沥青的粘度、沥青的用量、添加剂以及集料级配等,与热拌沥青混合料都有很大区别.实践表明,所研制开发的冷铺材料使用性能良好,而成本却比同类进口材料大大降低.     

Sensitivity analysis of parameters for multi-stand roll forming using a new booting model

Multi-stand roll forming is a process that has very complicated deformation behaviour and shows significant nonlinearity.In this paper, the sensitivity analysis of parameters for multi-stand roll forming was performed via a new booting finite element method(FEM) model.Compared with the most of simulation, the new model is more consistent with production process and can account for the effects of roll rotating speed.Based on the model, the process of an open section channel formed with 10 passes was simulated and the sensitivity analysis was conducted with orthogonal experiment design combined FEM model.The multi-stand roll forming process can be efficiently analyzed by the new booting model.And sensitivity analysis shows the hardening exponent plays an important role in controlling the quality of the products.     

浅谈软土泥沼地基的处理方法

介绍了软土及泥沼地基处理方法,有换土垫层法、强夯法、侧向约束法、土工织物加固法、排水固结法、综合处理方法的机理和适用范围。     

浅谈SEAM沥青混合料的施工工艺

介绍SEAM粒料的掺配方法、掺配比例的确定和SEAM沥青混合料的施工工艺。     

关于双箱变截面连续性箱梁的施工

通过实际施工。简单的归纳一下双箱变截面连续箱梁的施工工艺及基本作业方法。     

采用变化基本体的授课方法以提高教学效果

在《机械（工程）制图》教学中,学生对基本体的变化及其在实际中的应用难以理解,文中介绍提高基本体教学效果的方法。     

Role of candesartan against cerebral ischemia and oxidative damage in normotensive rats

Objective Angiotensin Ⅱ (Ang Ⅱ ) contributes to modulating blood pressure by stimulation of Ang Ⅱ AT1 receptors. We devised a rat transient middle cerebral artery occlusion (MCAO) model to assess whether oxidative damage is decreased after pretreatment with Angiotensin Ⅱ AT1 receptor blocker (ARB). Methods After 2 weeks pretreatment with ARB 0. 5 and 1 mg/kg, the male Wister rats were subjected to 2 h middle cerebral artery occlusion (MCAO). At 24 h, the lumen diameter of middle cerebral artery, the plasma level of 8-hydroxy-2'-deoxyguanosine (8-OHdG), and HIF-1 a levels were recorded and compared. Results After pretrcatment with ARB 0.5 and 1 mg/kg, blood pressure did not significantly change compared with that of controls. In the group of candesartan at 1 mg/(kg· day), the lumen diameter was significantly increased compared to that in control group [(86.0±5.0) μm vs. (69.0± 2.1) μm; P<0. 01, n = 6- 8]. The plasma 8-OHdG levels of ARB pretreatment groups were decreased. In immunohistochemical findings, 8-OHdG- and HIF-1α-containing cells in ARB pretreatment groups were decreased. Conclusion Brain ischemia and oxidative damage can be reversed by AT1 receptor blockade in normotensive rats after transient cerebral artery occlusion.     

The role of interleukin-8 produced by tumor induced fibroblasts in the development of cutaneous melanoma

Objective To determine the role of interleukin-8 (IL-8) produced by tumor induced fibroblasts in the development of cutaneous melanoma. Methods B16 melanoma cells induced L929 fibroblasts phenotype was transdifferentiated to myofibroblasts (MF) by co-culture in vitro. MF was monitored by morphology and immunophenotype for a-SMA. The level of IL-8 was detected by ELISA. The effect on B16 cell proliferation rate was estimated using MIT method in vitro. Melanoma implanting model was constructed in C57 mice. Results L929 MF phenotype could be modulated by B16 melanoma cells-derived transforming growth factor-β1 (TGF-β1) and elevated the levels of IL-8. L929 MF did not influence the B16 melanoma cells viability in vitro, but shortened the time of tumor formation and increased the incidence rates of tumors in C57 implanting model mice. Conclusion Fibroblasts can be activated by tumor cells and produce IL-8, which acts as an inflammatory cytokine promoting the development of cutaneous melanoma.