HXD1型机车自动驾驶系统设计与应用

主要介绍HXD1型交流传动电力机车的自动驾驶系统方案设计与应用情况,以机车改动最小、成本最低为原则,通过加装自动驾驶系统设备、通信及供电线缆实现自动驾驶功能。通过机车自动系统的成功运用,降低了人工劳动强度,杜绝了人为失误因素,提升了机车操纵水平和操纵一致性。     

Dynamic demand estimation and prediction for traffic urban networks adopting new data sources

Nowadays, new mobility information can be derived from advanced traffic surveillance systems that collect updated traffic measurements, both in fixed locations and over specific corridors or paths. Such recent technological developments point to challenging and promising opportunities that academics and practitioners have only partially explored so far.The paper looks at some of these opportunities within the Dynamic Demand Estimation problem (DDEP). At first, data heterogeneity, accounting for different sets of data providing a wide spatial coverage, has been investigated for the benefit of off-line demand estimation. In an attempt to mimic the current urban networks monitoring, examples of complex real case applications are being reported where route travel times and route choice probabilities from probe vehicles are exploited together with common link traffic measurements.Subsequently, on-line detection of non-recurrent conditions is being recorded, adopting a sequential approach based on an extension of the Kalman Filter theory called Local Ensemble Transformed Kalman Filter (LETKF).Both the off-line and the on-line investigations adopt a simulation approach capable of capturing the highly nonlinear dependence between the travel demand and the traffic measurements through the use of dynamic traffic assignment models. Consequently, the possibility of using collected traffic information is enhanced, thus overcoming most of the limitations of current DDEP approaches found in the literature.     

浅埋顶管沉井周边土体的三维破坏形状及沉降研究

为研究顶管沉井及周边土体在顶进力作用下的形变范围与大小，以加固旋喷桩作为沉井周围加固体建立ABAQUS软件计算模型，并将模拟结果与工程实例、PLAXIS 3D软件所得结果进行对比分析。同时，采用广州地区花岗岩残积土进行室内沉井模型试验，并通过试验结果对数值模拟结论进行验证，得出结论如下： 1）在开挖基坑前达到设计强度的旋喷桩能有效减小基坑周边土体塌陷变形、坑底隆起。2）在施加工作顶推力下，前侧主动区首先出现贯通裂缝，竖向位移斜率增大出现明显拐点；继续增大顶推力，土体位移会急剧增大导致地表沉降严重。3）对于后背土体，在顶推力作用下，地表破裂线的切线角度从0°逐渐增大至45°+φ/2，导致破裂范围也不断扩大；达到45°+φ/2处后，继续施加顶推力会导致短轴方向破坏范围扩大的速度较长轴方向的速度更快；三维空间中被动区破坏土体在地表处产生形状为椭圆的破坏面，椭圆长轴方向为顶推轴线方向，被动破坏体呈现为牛角状椭圆楔体。     

Caterham Seven 420R v Porsche 911 GT3 RS

在赛道作为一条经验法则,除非420R在打滑,否则其实它根本没用尽全力。它会转向不足——其实有时还挺有用的,如果你非要找到它的极限并再用力推过头一点点的话;但如果你就是入弯时对前胎要求过高那它就那么有帮助了。Seven之妙处在于驾驶者可以立刻知道当前的情况。你完全可以在入弯到     

基于灰色残差GM（1，1）模型的道路交通量预测的研究

道路交通体系是一个多因素、多层次、多目标的复杂系统。其中交通量信息系统具有明显的层次复杂性,结构关系的模糊性,动态变化的随机性,指标数据的不完全和不确定性。由于技术方法、人为因素、自然环境变化的影响,造成各种数据误差、短缺甚至虚假现象,系统的作用机制不明确,系统的状态、结构、边界关系难以精确描述,属于典型的灰色系统。在作量化、模型化、实体化研究时,能作为反映系统主要动态特征的数据是很少的。由于环境对系统的干扰,系统信息中原始数据序列往往呈现离乱情况,离乱数列即为灰色数列或称灰色过程,灰色理论利用那些较少的或不确切的表示系统行为特征的原始数据序列作生成变换后建立微分方程,对灰色过程建立的模型称为灰色模型（Greymodel）,简称GM模型。本文从理论上介绍了GM（1,1）模型和灰色残差GM（1,1）模型建立的一般过程,然后将其应用于交通量预测的实际例子中。预测结果表明,该方法是可行的。     

快速老化小鼠的学习记忆缺陷及其生化机制

目的用快速老化小鼠(SAMP8)模拟老年痴呆,观察其学习记忆能力,并探讨其学习记忆能力下降的可能机制。方法采用10月龄SAMP8,并用同龄抗快速老化小鼠(SAMR1)作为正常对照。用水迷路检测近记忆以及空间学习记忆能力。用生物化学方法检测大脑皮层线粒体膜电位和ATP酶活力,观察线粒体功能;检测皮层和海马胆碱乙酰基转移酶(ChAT)和乙酰胆碱酯酶(AChE)的活力,观察中枢胆碱能神经功能;检测血清超氧化物歧化酶(SOD)活力和丙二醛(MDA)含量,观察其全身性氧化应激状况。结果与SAMR1相比,SAMP8出现明显的衰老体征,其近记忆和空间学习记忆能力明显减弱,具有衰老和痴呆特征;皮层线粒体膜电位和ATP酶活力显著降低,海马ChAT活力显著下降,AChE活力显著升高,血清SOD活力稍有增高。结论SAMP8可以很好地模拟老年痴呆,其机制包括大脑皮层线粒体功能降低、海马胆碱能神经功能下降以及氧化应激等。     

VEGF-C、VEGFR-3和podoplanin在食管癌中的表达及其意义

目的观察血管内皮生长因子C(VEGF-C)及其受体3(VEGFR-3)和肾小球上皮细胞整合膜蛋白(podoplanin)在食管癌组织中的表达,分析其与肿瘤淋巴结转移的关系。方法免疫组织化学SP法检测76例食管癌组织中VEGF-C、VEGFR-3和podoplanin的表达及淋巴管密度(LVD)。结果食管癌VEGF-C表达阳性率为63.1%,VEGF-C的表达与食管癌的淋巴结转移、TNM分期有统计学意义(P<0.01,P<0.05),但与患者年龄、肿瘤大小及分化程度无关;癌旁组织淋巴管密度同淋巴结转移、VEGF-C阳性表达间有统计学意义(P<0.01,P<0.05),podo-planin LVD值与VEGFR-3 LVD值相比,具有统计学意义(P<0.01)。结论食管癌组织中VEGF-C表达与肿瘤TNM分期、淋巴管密度和淋巴结转移有关,VEGF-C表达越高,淋巴管密度越大,淋巴结转移可能性越高。癌旁组织LVD同VEGF-C的高表达及淋巴结转移密切相关,食管癌组织中podoplanin标记的淋巴管密度较VEGFR-3标记的淋巴管密度更为精确,是一种更为满意的淋巴管内皮特异性标志物。     

Effect of ABCA1-V771M polymorphism on plasma lipid levels and its relationship with coronary atherosclerotic heart disease

Objective To explore the risk association of ABCA1-V771M polymorphism with coronary heart disease (CHD) in Hart nationality in Northwest of China. Methods With case-control study, ABCA1-V771M polymorphism was detected in 204 unrelated Hart nationality people in Northwest of China, and all the subjects by coronary angiography were grouped into 106 cases and 98 controls. The genotypes and alleles frequency distribution of ABCA1-V771M polymorphisms were analyzed by PCR-RFLP analysis, and the clinical statistics of serum lipids were compared and its effects of ABCA1-V771M polymorphism on the plasma lipid levels and coronary atherosclerotic heart disease were analyzed. Results The genotypic frequencies of ABCA1-V771M polymorphism matched well under Hardy-Weinberg equilibrium (P>0.05), V and M allelic frequencies were 33.3% and 66.7%. In comparison with VV VM genotype carriers, MM genotypes carriers had much lower plasma levels of HDL-C (P<0. 001) and much higher plasma levels of TG (P<0. 05). M allelic frequency in CHD group was significantly higher than V allelic frequency (P<0. 05). M allele was related with more severity of atherosclerosis in the coronary artery than V allele (P<0.05). However, there was no obvious difference in the incidence of AMI among carriers with three genotypes of ABCA1-V771M polymorphism (P>0.05). Conclusion ABCA1-V771M polymorphism was not only associated with the plasma levels of HDL-C and TG, but also related to the susceptibility and severity of coronary atheroselerotic heart disease. Moreover, M771 allele appeared to be atherogenie among Han population in Northwest of China.     

一级公路交叉口设计中的交通安全问题及对策

一级干线公路由于开口较多,不可避免地存在较多的交通安全问题.文章以湖北荆监一级公路为例,针对交叉口设计中的交通安全典型问题,提出了改善方法及相关对策.     

改进不等时距GM模型在施工控制中的应用

刚构桥施工过程中应力变化复杂,影响因素多,较难预测把握应力发展趋势,实测应力缺失时,单一使用GM(1,1)模型预测精度低,对原始应力数据要求苛刻.文章改进了不等时距GM(1,1)模型,结合罗天乐特大桥工程进行验证,结果表明,改进不等时距GM(1,1)模型在刚构桥施工应力预测中具有较好的适用性和较高的预测精度.