The changes of neuronal activity of the zone incerta in a rodent model of Parkinson＇s disease

Objective To study the changes in neuronal activity of the zone incerta (ZI) following the unilateral lesion of the nigrostriatal pathway. Methods Eiectrophysiological recordings of ZI neurons were made in normal rats and in two groups of rats at different time intervals after injection of 6-hydrodopamine (6-OHDA) into the pars compacta of snbstantia nigra by extracellular recording in vivo. Results The results showed a significant increase in the mean firing rate of ZI during the second and fourth weeks after 6-OHDA lesion [-n=32, (3.6±2. 2)Hz, P<0.001; n=35, (9.3±6.6)Hz, P<0. 001, respectively] compared to that of normal rats [n=39, (9.2±5.2)Hz]. However, no significant change was observed between two groups of 6-OHDA-lesioned rats. With regard to firing pattern, 7.7%(3/39) of ZI neurons discharged regularly, 82.1% (32/39) irregularly and 10. 3% (4/39) in bursts in normal rats. During the second week after 6-OHDA lesion, the regular, irregular and bursting firing neurons recorded in the ZI were 9.4% (3/32), 59. 4% (19/32) and 31.3% (10/32), and during fourth week, the regular, irregular and bursting firing neurons were 14.3% (5/35), 57.1% (20/35) and 28. 6% (10/35), respectively. The firing pattern of the neurons in the three different groups did not change significantly. Conclusion These results suggest that the firing rate of ZI neurons in 6-OHDA-lesioned rats is increased significantly, which may contribute to the pathophysiology of Parkinson's disease.     

车市波动规律的新发展

为分析中国车市当前发展趋势,给汽车产销单位和领导机关决策提供参考,文章采用“车市波动分析法”,从宏观经济与车市波动关系入手,进行数据处理,作出车市波动图和数据表。分析研究后得出以下结论：中国车市2009年底已进入“第6次扩张高峰期”,达到创纪录的新水平,但后继波动恐难避免。文章根据中国车市发展实际提出波形组成内容变化新建议。     

不同布桩形式对桥墩地震响应的影响

该文结合典型工程实例,对五种不同的桩基布置形式建立有限元模型,分析不同布桩形式对桥墩地震内力的影响。在水平地震荷载作用下,增加桩基的刚度和数量不一定能改善桥墩受力,需要在顺桥向和横桥向分别输入地震波综合考虑桥墩地震响应,从而得到合理的桩基布置。     

上海轨道交通1、2号线列车编组“6改8”项目的技术对策及实施效果分析

介绍了上海轨道交通1、2号线运能与日益增长的客流之间的矛盾,提出了通过对既有列车进行“6改8”扩编改造的解决方案.以AC01、AC02和DC01型列车增扩编改造为例,对其技术难度和改造内容进行了分析和说明.已实施的该项扩编改造工作不仅克服了车辆改造所遇到的若干技术难题,而且还有效解决了在列车扩编改造期间所造成的运能不足的问题.     

基于TMS320C6416 DSP/BIOS的FLASH引导方式的实现

通过FLASH来引导DSP是实际应用中一种常见的应用方式,基于TMS320C6416 DSP/BIOS ,详细讨论如何配置存储区、代码段和数据段, 如何编写二次引导程序,生成复制表,以及怎样将COFF文件转换为便于FLASH 烧写的.hex文件.     

基于身份与位置分离体系结构的列车通信方案研究

在传统的互联网体系结构中,IP地址既作为节点的位置标志又作为节点的身份标志,难以适应列车通信。针对这一问题,提出身份与位置分离体系结构,并设计一种列车通信方案。在基于身份与位置分离体系结构的列车通信方案中,IP地址只作为节点的位置标志,引入端点标志符作为节点的身份标志,使得节点移动时也不会中断连接。列车中的节点通过移动网关接入互联网,对于MANET节点发送给互联网节点的数据报文,移动网关在转发之前需要对该数据报文重新封装;当节点移动时,利用路由更新选项和路由确认选项进行路由更新,并且这些选项都封装在IPv6逐跳选项报头中,不需要额外的信令开销。性能仿真及分析表明,与基于MIPv6的通信方式相比,该方案具有更高的报文递交率以及更低的报文开销。     

全海深双球连接耐压舱的结构设计探索

钛合金耐压球壳被广泛地应用于大深度载人潜水器.但是,由于受到材料强度的限制,若采用成熟的Ti-6Al-4VELI来设计3人型的全海深载人舱,其壁厚将超出很多国家的现有制造能力.为了解决这一矛盾,该文提出了一种新的双球连接的方案,并以中国船级社最新的强度标准作为优化约束条件,用有限元分析法对这种结构形式进行了优化设计.最后,对双球结构方案与传统单球方案作了比较.     

嵌入式油船排油监控系统的设计

以基于ARM Cortex^(TM)-M3内核的STM32F107VCT6微处理器为硬件平台,将μC/OS-II嵌入式实时操作系统移植到微处理器之上,搭建了系统软件开发平台,开发出排油监控系统控制器,集数据采集、GPS定位、分析计算、指令执行、数据存储、记录打印等功能于一体。给出了控制单元具体的软硬件实现方法,在.Net开发环境下利用Visual C#编程语言完成计算机监控软件的构建,实现了与控制单元的通信。在油船货油装卸模拟系统的运行结果表明,该排油监控系统可满足国际海事组织(IMO)关于油船排油监控系统的有关要求。     

2-氯-6-N-芳基取代嘌呤衍生物的合成

N6嘌呤衍生物是重要的核苷类药物的中间体.以2-氨基-6-氯嘌呤为原料,通过重氮化反应制得2,6-二氯嘌呤,收率30.5%.2,6-二氯嘌呤分别与苯胺、邻氯苯胺和对氯苯胺,通过N-烃基化反应制得2-氯-6-N-芳基嘌呤,收率75.2%;2-氯-6-N-2′-氯苯基嘌呤,收率68.5%和2-氯-6-N-4′-氯苯基嘌呤,收率63.2%.使用元素分析、核磁共振、质谱和红外光谱对所得产品进行分析,结果表明所得产品为目标产品.2-氯-6-N-芳基取代嘌呤衍生物合成的最佳工艺条件为：n（2,6-二氯嘌呤）∶n（苯胺衍生物）=1∶5,使用戊醇为反应中的溶剂,其用量为m（C5H11OH）∶m（2,6-二氯嘌呤）=23∶1,反应温度为80℃.     

The importance of Öresund and the Drogden Sill for Baltic inflow

Based on high resolution current and salinity measurements from the Flinten and Drogden Channels, this paper assesses the relative importance of major Baltic inflows on ‘everyday' flow conditions of highly saline water (S>17 PSU) through the Öresund for a period of 43 months. During years with no major Baltic inflows, 1994–1996, it is found that the Öresund on average supplies 1.2 Peta-grams (Pg) of salt net/year to the Baltic, while inflow above 17 PSU is in the order of 2.3 to 4.0 Pg/year. Sixty percent of this inflow is in the salinity range 17–23 PSU; the remainder has a higher salinity. It is, thus, concluded that normal and regularly occurring flow in the Öresund plays a much larger role in supplying salt to the Baltic than is usually assumed.