兔眼环孢霉素A缓释微球的眼内释药性研究

目的建立兔眼房水中环孢霉素A缓释微球的高效液相测定方法,考察在不同给药剂量下兔眼房水中的药物代谢特性,为该药预防后发性白内障提供理论依据。方法兔眼行晶体囊外摘除,左眼前房及囊袋内注射环孢素微球,右眼给予空白微球作对照,采用高效液相色谱法监测给药后4周内兔眼房水中环孢霉素A的浓度。色谱柱为反相C18硅胶柱,柱温为60℃,流动相为乙腈-水(67∶33),检测波长210nm。结果兔眼房水中环孢霉素A的浓度在0.13-1.25mg/L范围内呈良好线性关系(r=0.9951),最低检测浓度0.13mg/L,回收率95.91%,日间和日内精密度均小于5.0%。缓释微球的释药速率适中,兔眼前房给药后可在2周内维持较高浓度,高低两种给药剂量下,环孢霉素A的吸收半衰期(t1/2Ka)和血浆清除速率(CL)经检验无统计学差异,药时曲线下面积(AUC)和峰浓度(Cmax)与剂量之间线性相关。结论环孢素A缓释微球在兔眼内有较高的生物利用度,实验期内可达到抑制后发性白内障的有效浓度。     

一级公路交叉口设计中的交通安全问题及对策

一级干线公路由于开口较多,不可避免地存在较多的交通安全问题.文章以湖北荆监一级公路为例,针对交叉口设计中的交通安全典型问题,提出了改善方法及相关对策.     

甲、乙型肝炎病毒重复感染的血清学检测

本文分析60例甲、乙型肝炎病毒重复感染的血清学检测结果,提示重复感染占当时住院肝炎病人的14.8%。在重复感染中,同时感染甲、乙两型肝炎者9例;乙肝抗原携带者及慢性肝炎基础上感染甲肝者41例;乙肝隐性感染免疫后又感染甲肝者10例.同时观察到部分病人重复感染时,HBsAg 滴度下降或消失。并探讨了肝炎复发或突然加重的原因,认为两种肝炎病毒重复感染是肝炎复发或者突然加重的主要因素.故预防HBV 携带者及慢性乙肝重复感染其他肝炎病毒十分重要.     

基于粒子群算法的水下多元线阵阵形有源校正方法

针对存在阵元位置误差的水下多元线阵,提出一种基于粒子群优化算法的远场有源阵形校正方法.该方法选用2个辅助源分时工作方式,利用无条件最大似然方位估计算法构建目标函数,并通过粒子群算法对阵元位置进行寻优.利用该方法对均匀线阵进行性能仿真实验.结果表明:该方法稳健性好、校正精度高,具有一定的应用前景.     

基于三元阵的舰船水压场微弱信号检测方法研究

利用三元阵水压场同步测试系统一次海上实船水压场测试试验的三阵元数据开展了低信噪比实船水压场的特征提取和检测方法研究.结合三阵元,分别采用了自适应滤波方法和功率谱估计方法对所获得的试验数据进行分析处理.结果证明,基于自适应滤波和基于功率谱估计的三阵元联合浮动门限能量检测方法能有效抵消噪声干扰,所设计的浮动门限随海浪背景噪声的变化而调整,具有很好的适应性,能在低信噪比下达到较高的信号检测率.     

Soil Body Deformation Caused by Construction of a Double-Line Shield Tunnel with Multiple Factors北大核心CSCD

Considering the influence of many factors (soil loss, frontal additional thrust, the friction force of the shield shell and the additional grouting force), a method for improving the uniform soil body movement model is pro-posed, and a mechanical calculation model is established to study the calculation method for soil body deformation caused by double-line parallel shield driving. Based on the Mindlin solutions of elastic mechanics, the theoretical solutions for soil body deformations caused by the last three factors are calculated; considering the uniform soil body movement model, the theoretical solutions for soil body deformations caused by soil loss are calculated, then the to-tal theoretical solutions for soil body deformations under multiple factors are obtained by means of superposition. The vertical surface settlement, vertical horizontal displacement, and vertical displacements of the soil body at different depths of Hangzhou Metro Line 1 are calculated to analyze the variation laws. Meanwhile the influential factors for horizontal displacement variation are studied. The research shows that with a change of depth, the settlement of the soil body changes within the scope of 10 to 13 m in the horizontal direction near where the maximum settlement occurs;the direction of the horizontal displacement of the soil body changes with a change of the positional relationship be-tween the calculation points and the tunnel; and with an increase of interval J for the two tunnels, the horizontal dis-placement of the soil body of a deep double-line tunnel decreases while the displacement near the surface changes slightly. © 2018, Editorial Office of "Modern Tunnelling Technology". All right reserved.     

城市客车内饰风道设计简述

城市客车内饰风道设计的好坏对车辆的运行性能似乎没有什么影响,往往容易被忽视。风道不仅影响到内饰的美观而且对空调客车内室的保温、减少空调系统的损失,提高运行经济性起到至关重要的作用。这里对城市客车风道的结构设计、材料应用及其隔热措施保温提出了自己的见解,并着重叙述了风道的保温。     

Sea state estimation based on vessel motion responses: Improved smoothness and robustness using Bézier surface and L1 optimization

Floating structures oscillate in waves, where these wave-induced motions may be critical for various marine operations. An important consideration is thereby given to the sea states at the planning and operating stages for an offshore project. The most important information extracted from a sea state is the directional wave spectrum, indicating wave direction, significant wave height, and wave spectrum peak period. Among several available methods of measuring and estimating the directional wave spectrum, the wave buoy analogy technique based on vessel motion responses is an in situ and almost real-time solution without extra costs of devices. If the forms of the wave spectra are not predefined in the estimation, the method is called a nonparametric approach. Its most remarkable advantage is the flexible form, but the smoothness should be regulated. After the discrete Fourier transform has been applied to the measured vessel motions, smoothing is necessary. However, this process results in disturbed vessel cross-spectra and a lowpass characteristic of the windowing function. This paper presents a nonparametric approach for directional wave spectrum estimation based on vessel motion responses. It introduces novel smoothness constraints using Bézier surface and includes a more robust estimate using L1 optimization. Both techniques are applied to the wave buoy analogy for the first time. Numerical simulations are conducted to verify the proposed algorithm.     

《中国舰船研究》2016年第1期目录

[1] 航空母舰发展的思考…朱英富,熊治国,胡玉龙(1)[2] 水面舰艇作战系统的回顾和展望…潘镜芙,董晓明(8)[3] 发展绿色舰船,抢占未来舰船发展制高点…马运义(13)[4] 舰船装备保障流程管理…朱石坚(19)[5] 高强度钢在潜艇应用中的若干重要问题综述…杨建明,张新宇,刘朝骏(27)[6] 水下爆炸气泡及其对结构毁伤研究综述…姚熊亮,刘文韬,张阿漫,刘云龙(36)[7] 舰艇抗爆抗冲击技术现状和发展途径…刘建湖,周心桃,潘建强,王海坤(46)[8] 流致噪声机理及预报方法研究综述…王春旭,吴崇健,陈乐佳,邱昌林,熊济时(57)[9] 我国舰船中压直流综合电力系统研究进展…付立军,刘鲁锋,王刚,马凡,叶志浩,纪锋,刘路辉(72)[10] 石墨烯及其在金属防腐中应用的研究进展…龚佑宁,于连江,潘春旭(80)[11] 等离子体技术处理舰船固体废弃物的进展…吕东方,于开录,岳强(89)[12] 新概念穿梭艇自航模操控系统试验研究…王健,刘旌扬,魏成柱,李英辉,易宏(95)[13] 实验尺度无人水下滑翔机设计与试验…杨海,刘雁集,张凯(102)[14] 基于惯容器的机械振动被动控制系统传递特性分析…刘彦(108)[15] 基于数字样机的舰船维修性设计分析技术…方强,王松山,祝泓,张平(114)[16] 大型舰船物资转运瓶颈解析计算及分段优化方法…金迎村,宗砚,王皎(121)[17] 船舶纵向下水曲线直接计算法…林诗尧,孙江龙,曾荆州,解德(128)[18] 舰船集成冷媒水系统损害检测…徐新华,李伟光,谢军龙(135)[19] 《中国舰船研究》创刊10周年发展回顾及文献计量学分析…易基圣,喻菁,许建(143)     

改进不等时距GM模型在施工控制中的应用

刚构桥施工过程中应力变化复杂,影响因素多,较难预测把握应力发展趋势,实测应力缺失时,单一使用GM(1,1)模型预测精度低,对原始应力数据要求苛刻.文章改进了不等时距GM(1,1)模型,结合罗天乐特大桥工程进行验证,结果表明,改进不等时距GM(1,1)模型在刚构桥施工应力预测中具有较好的适用性和较高的预测精度.