上海动车段试验线列控车载设备测试系统

主要介绍上海动车段试验线车载设备测试系统的功能、系统组成、控制原理及主要控制流程,举例介绍测试场景及测试方法,系统满足CTCS-2级列控系统车载设备动态测试功能需求,预留CTCS-3级列控系统车载设备动态测试条件。     

二三维一体化GIS在铁道部调度指挥系统中的应用研究

主要论述二三维一体化GIS技术在铁道部调度指挥系统中的应用方案,论述二三维一体化GIS技术的优越性,阐述铁道部调度指挥系统中二三维一体化GIS的平台选型、系统功能、设计方案,最后给出仿真环境下的系统效果,验证二三维一体化GIS技术在实际工程项目中的可行性。     

基于PDMS系统的城际动车组全三维设计研究

通过阐述城际动车组在Teamcenter和UG NX环境下采用数字化技术开发的过程、方法,介绍了PDMS系统文件数据的管理方式,自顶向下地适合动车组车辆协同设计的装配设计方法,大装配技术和车辆分系统出图的方法等,同时还提出并介绍了全数字化车辆模型在动车组车辆重量管理、干涉检查和设备布置优化等方面的应用,为轨道交通车辆全三维协同设计提供了一种设计参考。     

我国汽车行业电子商务发展模式研究

文章针对目前国内汽车电子商务模式的几点争论，结合中国电子商务的现实环境和汽车行业的实际情况。进行了充分论证。并借鉴国外汽车行业电子商务发展模式．提出了适台鼗国汽车行业电子商务的三阶段发展模式。     

Environmental and transport effects of warehouse relocationing: evidence from Norway

Reducing traffic volumes and CO2-emissions from freight transport has proven difficult in many countries. Although the increasing suburbanization of warehouses is seen as a relevant land use trend, comprehensive analyses of their impact remain scarce. This study uses real data in modeling transport, costs, environmental and modal effects from warehouse relocations around Oslo and Trondheim (Norway). Results indicate that for Oslo, traffic performance (ton-km), CO2-emissions, and transport costs increase following warehouse suburbanization. For Trondheim, transport performance and CO2-emissions increase less, while transport costs decrease marginally. We conclude that specific case characteristics (geography and trade patterns) are important in determining the strength and direction of effects, and expect that common concomitant developments (warehouse centralization and consolidation) would lead to more pronounced results. Our findings confirm some, but challenge other, findings from the relatively scarcely literature available. Finally, the study's more general insights and observations can help advance similar analyses beyond Norway.     

基于多源数据的公交车能耗碳排放测算模型

公交车能耗碳排放强度与车辆、线路和驾驶员有显著相关关系，为精准刻画其能耗碳排放强度特征，整合OBD监测数据、加油(气)数据、运营排班数据等多源数据资源. OBD监测数据和加油(气)数据呈显著的线性关系，证明修正后的OBD监测数据可满足分析要求. 搭建“速度-能耗碳排放强度曲线”测算模型，幂函数关系的拟合优度R2 =0.972 6 为最高. 实证研究发现，平均速度在10~60 km/h 变化时，液化天然气(LNG)车比柴油车能耗碳排放强度高 3.3%~33.7%，双层车比铰接车高2.4%~13.3%；LNG铰接车在不同线路、相同速度下的强度相差9.6%；不同驾驶员在相同线路的能耗碳排放强度可相差24.2%. 模型为各城市基于多源数据开展公交能耗碳排放目标设定提供数据支撑.     

羟基喜树碱对人胆管癌QBC939裸鼠移植瘤PS2、COX-2的影响

目的探讨羟基喜树碱对人胆管癌QBC939裸鼠移植瘤的乳癌相关肽(PS2)、环氧合酶-2(COX-2)的影响,分析PS2、COX-2与肿瘤发生、发展的关系。方法建立人胆管癌QBC939细胞株裸鼠皮下移植瘤模型,将30只裸鼠随机分成对照组、羟基喜树碱低剂量组和羟基喜树碱高剂量组,观察移植瘤体生长情况,RT-PCR法检测瘤体内PS2、COX-2 mRNA表达。结果与对照组比,羟基喜树碱低、高剂量组都可使移植瘤体的PS2 mRNA表达增高;COX-2 mRNA表达降低,且瘤体生长减慢,与对照组比较差异有统计学意义(P<0.01)。结论羟基喜树碱可降低移植瘤COX-2 mRNA表达,增高移植瘤体的PS2 mRNA表达,并使人胆管癌裸鼠移植瘤生长减慢。     

Study on T lymphocyte subsets and NK cells in patients with Graves＇ disease combined with type 2 diabetes

Objective To investigate changes in T lymphocyte subsets and NK cells in patients with simple Graves' disease (GD)and Graves' disease combined with type 2 diabetes mellitus (GD/T2DM). Methods Fifteen cases of GD/ T2DM were selected from our hospital from November 2001 to November 2004. Before and after therapy thyroid function, thyroglobulin antibody (TGA), thyroid microsomal antibody (TMA) and blood glucose level were measured, and T lymphocyte subsets (CD3, CD4, CD8, CD4/CD8) and NK cells (CD56) were measured by immunofluorescence double labeling monoclonal antibody and flow cytometry, respectively. At the same time, comparison was made with simple GD (15 cases), T2DM (15 cases) and healthy control (20 cases). Results Before therapy, CD4/CD8, CD4 and NK cells in GD/T2DM were less than normal, and there was no significant difference in comparison with simple GD (P<0.05). In T2DM group, only CD4/CD8 and CD4 were less than those of healthy controls (P<0.05). When thyroid function recovered after 1 to 3 months of methimazole treatment in both GD/T2DM and simple GD groups, various indexes recovered, which were more obvious in simple GD. Conclusion Immune hypofunction of GD may be the key to the immune abnormality of GD/T2DM, which is more significant than that of simple GD or T2DM. The recovery of thyroid function and immune abnormality is not consistent, and the recovery of GD is more significant than that of GD/T2DM.     

健胃愈疡颗粒对慢性胃炎伴幽门螺杆菌感染胃黏膜PAF、PS2的表达及对上皮细胞凋亡的影响

目的观察健胃愈疡颗粒(JWYY)对幽门螺杆菌相关性胃炎胃黏膜乳癌相关肽(PS2)和血小板活化因子(plate-let activating factor,PAF)表达的变化,并分析其可能的作用机制。方法80例幽门螺杆菌感染慢性胃炎患者随机分为2组,治疗组42例给予健胃愈疡颗粒治疗,对照组38例给予西药三联药物治疗。应用胃镜下活检胃黏膜组织快速尿素酶和Warthin-Starry染色法检测幽门螺杆菌,应用Western blot检测PS2、PAF表达变化。应用末端转移酶介导的dUTP切口末段标记法(TUNEL)检测细胞凋亡。第4周复查胃镜。结果治疗组凋亡指数明显比对照组减少(P<0.05),治疗组总有效率高于对照组(P<0.05)。Western blot检测显示:JWYY颗粒可上调PS2并下调PAF的表达,而对照组对胃黏膜PS2和PAF的表达影响不大。结论健胃愈疡颗粒治疗幽门螺杆菌(Hp)相关性胃炎可能与杀灭Hp、上调PS2和下调PAF的表达来抑制细胞凋亡有关。