乳腺癌VEGF-C的表达与淋巴管生成的相关性

目的探讨乳腺癌血管内皮生长因子C(vascular endothelial growth factor C,VEGF-C)的表达与乳腺癌肿瘤淋巴管生成及淋巴结转移的关系。方法用免疫组化SP法对60例乳腺浸润性导管癌进行VEGF-C染色,并用D2-40标记肿瘤淋巴管。取15例乳腺纤维腺瘤标本做对照。结果乳腺癌组VEGF-C阳性表达率明显高于对照组(P<0.01)。VEGF-C表达与乳腺癌淋巴管密度(lymphatic vessel density,LVD)和腋淋巴结转移相关;VEGF-C表达阳性组肿瘤淋巴管密度大(P<0.05),腋淋巴结转移组VEGF-C表达水平高。乳腺癌组所有病例均有不同程度的淋巴管染色,以肿瘤间质组织中淋巴管生成为主。淋巴管密度与乳腺癌腋淋巴结转移呈正相关,腋淋巴结转移组的肿瘤淋巴管密度比无淋巴结转移组高(P<0.05)。结论乳腺癌中存在淋巴管生成,且主要发生在肿瘤间质组织中;VEGF-C表达与肿瘤淋巴管生成及腋淋巴结转移相关。     

Relationship between the acid-suppression efficacy of proton pump inhibitors and CYP2C19 genetic polymorphism in patients with peptic ulcer

Obiective To investigate acid-suppression efficacy of proton pump inhibitors(PPls) in relation to CYP2C19 genetic polymorphism on patients with peptic ulcer. Methods By an open, randomized and control trial, fifty nine patients with active peptic ulcer were randomly assigned to receive one of three PPIs on a single dose (20 mg of each drug): omeprazole group (n=19), rabeprazole group (n=20) and esomeprazole group (n=20). lntragastric pH was recorded 1 hour before and 24 hours after administration. CYP2C19 genotype was tested in all patients. Resuits The EMs/PMs ratio of each group was 16/3,17/3 and 17/3, respectively. The total time that intragastric pH＞4, time percent pH＞4 and median pH in PMs patients were significantly higher than those in EMs patients of omeprazole group (P＜0.05). But all these differences were not found in rabeprazole group and esomeprazole group. The pH of nocturnal acid breakthrough (NAB) in both rabeprazole group and esomeprazole group was higher than that of omeprazole group, while there was no significant difference between rabeprazole group and esomeprazole group. Gonclusion The acid-suppression efficacy of omeprazole is highly dependent on CYP2C19 genetic polymorphism, while CYP2C19 genetic polymorphism may have a little influence on the acid-suppression efficacy of rabeprazole and esomeprazole. The acid-suppression action of rabeprazole and esomeprazole is superior to omeprazole, especially on night acid secretion.     

隧限-2隧道通行双层集装箱列车的可行性分析

随着集装箱物流的发展,部分既有铁路要改造为双层集装箱运输通道,然而既有铁路的隧道限界大多为隧限-2,不能满足双层集装箱运输隧道建筑限界。文章通过对限界、接触网悬挂方式及隧道处理措施等方面的研究,提出了隧限-2B隧道通行双层集装箱列车是可行的结论。     

基于气垫效应的二维楔形体入水砰击载荷预报方法研究

本文对二维刚性楔形体入水砰击问题进行研究,将数值模拟与模型试验结果进行对比分析,验证利用数值模拟方法研究入水砰击问题的可行性.获得气垫效应、斜倾角、入水速度对楔形体入水砰击压力峰值的影响规律,并分析了气垫效应对压力峰值的影响机理.最后对砰击载荷预报方法进行研究,获得不同斜倾角、不同速度下楔形体入水砰击压力峰值的预报公式.     

复杂心滩通航河段不同角度碛首坝对航道条件的影响*

长江上游河段多为基岩和卵砾石河床,常见心滩、浅滩及边滩等复杂边界碍航河段。由于工程实际需要及航道整治要求,经常存在采砂坑、开挖航槽、修筑碛坝等改变局部河道边界的情况。以长江上游占碛子河段为例,建立向右偏转0°、5°、10°碛首导流坝数学模型,分析表明:0°碛坝引起的水位壅高流速增幅和分流比变化均较小 ,对占碛子浅滩影响较小;5°碛坝对主槽分流比和航道通航水深及流速的优化更加明显,通航效果更优;10°碛坝对主槽通航条件的改善明显,对流场改变较大,引起了明显的河势演变。为长江上游复杂通航河段航道整治工程的设计和研究提供参考。     

2种SOFC-MGT底层循环系统性能对比分析

设计一种新型固体氧化物燃料电池与微型燃气轮机底层联合循环发电系统结构(SOFC-MGT底层联合循环2),基于Matlab/Simulink软件建立了SOFC-MGT底层联合循环2的仿真模型,并与传统的SOFC-MGT底层联合循环1的系统性能进行对比分析.结果 表明,SOFC-MGT底层联合循环2的电堆输出功率要低于底层...     

泸州港集装箱码头二期工程数学模型研究

在分析长江泸州河段基本特征的基础上,结合定床模型试验提出的集装箱码头二期工程实施方案,采用平面二维水流数学模型进行了水面线和流场分析计算,研究该工程修建后该河段通航条件的变化,结果表明建码头后该河段通航条件基本能满足通航要求.     

中空纤维膜接触器吸收低浓度CO2气体研究

采用疏水性中空纤维膜接触器为吸收装置,以一乙醇胺(MEA)为吸收液,对低浓度CO2(≤0.5%)进行吸收,考察吸收液浓度、吸收液流量、气体流量和进气CO2浓度对CO2吸收效率η和总体积传质系数KGa的影响规律.结果表明,膜吸收法可以处理浓度为0.1%～0.5%的CO2,且保持较高的吸收效率;吸收过程受气相阻力控制,液相阻力对CO2的传质性能影响不大.根据传质理论,建立传质数学模型,模型结果与试验结果基本一致.     

The Implementation of Mirror-Image Effect in MPEG-2 Compressed Video

Straightforward techniques for spatial domain digital video editing (DVE) of compressed video via decompression and recompression are computationally expensive. In this paper, a novel algorithm was proposed for mirror-image special effect editing in compressed video without full frame decompression and motion estimation.The results show that with the reducing of computational complexity, the quality of edited video in compressed domain is still close to the quality of the edited video in uncompressed domain at the same bit rate.