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重点阐述在涞水县7.21灾后公路恢复重建中,对桥梁水毁状况的调查分析以及工程重建设计要点,可为相关工作提供借鉴。 相似文献
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Objective Angiotensin Ⅱ (Ang Ⅱ ) contributes to modulating blood pressure by stimulation of Ang Ⅱ AT1 receptors. We devised a rat transient middle cerebral artery occlusion (MCAO) model to assess whether oxidative damage is decreased after pretreatment with Angiotensin Ⅱ AT1 receptor blocker (ARB). Methods After 2 weeks pretreatment with ARB 0. 5 and 1 mg/kg, the male Wister rats were subjected to 2 h middle cerebral artery occlusion (MCAO). At 24 h, the lumen diameter of middle cerebral artery, the plasma level of 8-hydroxy-2'-deoxyguanosine (8-OHdG), and HIF-1 a levels were recorded and compared. Results After pretrcatment with ARB 0.5 and 1 mg/kg, blood pressure did not significantly change compared with that of controls. In the group of candesartan at 1 mg/(kg· day), the lumen diameter was significantly increased compared to that in control group [(86.0±5.0) μm vs. (69.0± 2.1) μm; P<0. 01, n = 6- 8]. The plasma 8-OHdG levels of ARB pretreatment groups were decreased. In immunohistochemical findings, 8-OHdG- and HIF-1α-containing cells in ARB pretreatment groups were decreased. Conclusion Brain ischemia and oxidative damage can be reversed by AT1 receptor blockade in normotensive rats after transient cerebral artery occlusion. 相似文献
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JIANG Feng FENG Qi 《船舶与海洋工程学报》2007,6(4):48-54
Predicting damage to vibration isolators in a raft experiencing heavy shock loadings from explosions is an important task when designing a raft system. It is also vital to be able to research the vulnerability of heavily shocked floating rafts unreliable, especially when the allowable values The conventional approach to prediction has been or ultimate values of vibration isolators of supposedly uniform standard in a raft actually have differing and uncertain values due to defective workmanship. A new model for predicting damage to vibration isolators in a shocked floating raft system is presented in this paper. It is based on a support vector machine(SVM), which uses Artificial Intelligence to characterize complicated nonlinear mapping between the impacting environment and damage to the vibration isolators. The effectiveness of the new method for predicting damage was illustrated by numerical simulations, and shown to be effective when relevant parameters of the model were chosen reasonably. The effect determining parameters, including kernel function and penalty factors, has on prediction results is also discussed. It can be concluded that the SVM will probably become a valid tool to study damage or vulnerability in a shocked raft system. 相似文献