空心板梁预应力体外索加固技术应用

以具体的工程实例为背景,介绍采用法兰螺丝对空心板桥梁施加横向无粘接预应力,加固有纵向裂缝桥梁的基本工作程序及施工要点,为桥梁加固工程提供参考.     

Study on T lymphocyte subsets and NK cells in patients with Graves＇ disease combined with type 2 diabetes

Objective To investigate changes in T lymphocyte subsets and NK cells in patients with simple Graves' disease (GD)and Graves' disease combined with type 2 diabetes mellitus (GD/T2DM). Methods Fifteen cases of GD/ T2DM were selected from our hospital from November 2001 to November 2004. Before and after therapy thyroid function, thyroglobulin antibody (TGA), thyroid microsomal antibody (TMA) and blood glucose level were measured, and T lymphocyte subsets (CD3, CD4, CD8, CD4/CD8) and NK cells (CD56) were measured by immunofluorescence double labeling monoclonal antibody and flow cytometry, respectively. At the same time, comparison was made with simple GD (15 cases), T2DM (15 cases) and healthy control (20 cases). Results Before therapy, CD4/CD8, CD4 and NK cells in GD/T2DM were less than normal, and there was no significant difference in comparison with simple GD (P<0.05). In T2DM group, only CD4/CD8 and CD4 were less than those of healthy controls (P<0.05). When thyroid function recovered after 1 to 3 months of methimazole treatment in both GD/T2DM and simple GD groups, various indexes recovered, which were more obvious in simple GD. Conclusion Immune hypofunction of GD may be the key to the immune abnormality of GD/T2DM, which is more significant than that of simple GD or T2DM. The recovery of thyroid function and immune abnormality is not consistent, and the recovery of GD is more significant than that of GD/T2DM.     

弥漫性轴索损伤后CD4~+/CD8~+ T细胞比值、IL-6、IL-10水平变化及预后相关危险因素的Logistic回归分析

目的研究弥漫性轴索损伤(DAI)后患者外周血CD4+/CD8+T细胞比值及炎症因子IL-6、IL-10水平的变化,探讨影响DAI患者预后的相关危险因素及可能的预测因子。方法收集115例DAI患者的相关临床资料及伤后至少6个月的随访结果,并将采集的患者外周血采用流式细胞仪检测CD4+、CD8+T细胞及其比值,ELISA法检测IL-6、IL-10水平,对免疫炎症指标及临床资料进行单因素和多因素分析,多因素分析采用Logistic回归分析。结果DAI后合并其他脑损伤、瞳孔改变、伤后昏迷时间及入院时GCS评分是影响患者预后的危险因素,而其他因素则与预后不相关。CD4+/CD8+T淋巴细胞比值降低是DAI后发生ARDS/ALI的危险因素,CD4+/CD8+T淋巴细胞比值与患者预后关系不大,而ARDS/ALI的发生则是影响DAI患者预后的重要危险因素。IL-6增加与DAI后ARDS/ALI密切相关,可作为ARDS/ALI发生的预测因子,其水平是患者预后的危险因素,而IL-10则在此过程中与ARDS/ALI不相关,且与患者预后无关。结论 CD4+/CD8+T淋巴细胞比值降低是DAI后发生ARDS/ALI的危险因素,IL-6可作为ARDS/ALI发生的预测因子。DAI后与患者预后相关的危险因素包括合并其他脑损伤、瞳孔改变、伤后昏迷时间、入院时GCS评分、IL-6水平及并发ARDS/ALI。     

CD4~+CD25- CD45RB~(high) T细胞转移性肠炎模型的建立

目的建立CD4+CD25-CD45RBhighT细胞转移性肠炎模型,并分析其在炎性肠病中的研究价值。方法流式细胞仪分选和纯化CD4+CD25-CD45RBhighT细胞并通过静脉注射移植到Rag1-/-小鼠,记录每组小鼠体质量变化,根据标准程序制作结肠组织切片进行HE染色检查,分离肠黏膜固有层CD4+T细胞并采用ELISA方法检测TNF-α和IFN-γ的表达水平。结果 CD4+CD25-CD45RBhighT细胞重建Rag1-/-小鼠3周后出现体质量下降,至第6周时体质量下降更加急剧并伴有明显腹泻。结肠组织切片结果发现明显的炎性细胞浸润,结肠上皮出现局灶性溃疡,炎症进一步蔓延至黏膜下层。结肠黏膜固有层CD4+T细胞TNF-α和IFN-γ的表达水平明显高于对照组。结论CD4+CD25-CD45RBhighT细胞转移性肠炎模型在研究炎性肠病的发病机制中具有重要作用。     

海上平台滑道梁校核推荐算法

滑道梁是海上平台用来拆装维修的重要工具。由于平台结构的特殊性,滑道梁结构差别很大,其强度的校核计算相当复杂。文章对滑道梁系统进行大量力学分析,并从工程计算的角度对其复杂的力学模型进行合理简化,以钢结构承载能力极限状态为准则,推导出滑道梁校核的一般通用性方程,为工程设计提供可行的计算依据。     

梯形载荷作用下功能梯度简支梁弯曲的解析解

基于应力函数法,对梯形分布载荷作用下、材料属性在厚度上任意变化的功能梯度简支梁弯曲问题的解析解进行了研究。首先引入了一个应力函数,根据平面应力问题的基本方程,得出了功能梯度梁的应力函数应满足的偏微分方程,并根据应力边界条件得出了应力函数及各向应力的表达式;进而根据功能梯度材料的本构方程和位移边界条件,得出了各向应变与位移的显式解析表达式。在算例中,分别采用文中方法和经典理论对均质各向同性梁进行求解,验证了文中方法的正确性;并求解了材料组分呈幂律分布的功能梯度梁的应力和位移分布,分析了上下表层材料的弹性模量比λ与组分材料体积分数指数 n 对应力和位移分布的影响。     

T型接头横向埋藏裂纹扩展特性

基于断裂力学理论和有限元分析,研究T型接头横向埋藏裂纹扩展特性,实现了双向拉伸载荷作用下T型接头横向埋藏裂纹扩展形状变化的数值模拟。结果表明:T型接头横向埋藏裂纹扩展至结构表面时的形状为近圆形,与裂纹埋藏位置和初始形状无关;埋藏于焊趾端部板材中的裂纹扩展快于埋藏于焊缝中的裂纹扩展。     

简支变连续梁法加固多跨T梁桥效应分析

多跨简支T梁变连续加固措施是多跨简支T梁桥加固改造、提高承载能力的行之有效的方法.但实践中发现该方法存在着一定的问题.以跨径为16.76m+16.76m的两跨简支T梁为例,通过理论分析计算表明,该方法在提高跨中抗弯承载能力的同时,却降低了中间支点处梁的抗剪承载能力.建议在采用此方法加固多跨简支T梁的同时应对中间支点梁的抗剪能力进行加固.     

The receiving of chirp signals with frequency invariant beam response

1 Introduction1 The sensor array and the correlative signal processing methods have been adopted for the ability improvement of detection and orientation in modern sonar systems, and beamforming is a widely used tool in sensor array signal processing for …