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目的探讨三硝基苯磺酸(TNBS)/乙醇灌肠液诱导大鼠溃疡性结肠炎TLR4/NF-κB和PI3K/AKT/NF-κB信号通路的表达及电针的干预作用。方法雄性Wistar大鼠240只,随机分为正常对照组、模型组、电针组、TLR4单克隆抗体(TLR4mAb)组、LY294002组和TLR4mAb-LY294002联合治疗(T&L)组。以TNBS/乙醇溶液灌肠诱导大鼠溃疡性结肠炎模型,电针组造模同时给予电针足三里穴治疗,TLR4mAb组给予TLR4mAb腹腔注射,LY294002组则予LY294002注射液腹腔注射,T&L组则同时给与上述TLR4mAb和LY294002腹腔注射,共4周,每日行疾病活动指数(DAI)评分。造模4周后处死大鼠取结肠组织标本,评价结肠黏膜损伤指数(CMDI)和组织学损伤指数(TDI);免疫印迹法测定结肠黏膜磷酸化AKT(P-AKT)和活化NF-κB含量;RT-PCR法检测结肠组织中TLR4mRNA、PI3K mRNA、AKT mRNA、NF-κB mRNA、TNF-αmRNA及IL-1βmRNA表达。结果与正常对照组比较,模型组结肠组织TLR4mRNA、PI3K mRNA、P-AKT、活化NF-κB、TNF-αmRNA、IL-1βmRNA表达和DAI、CMDI及TDI均显著升高(P<0.01);与模型组比较,TLR4mAb组TLR4mRNA表达显著下降(P<0.01),LY294002组PI3K mRNA、P-AKT表达显著下降(P<0.01),而在电针组和T&L组TLR4mRNA、PI3K mRNA及P-AKT表达均明显降低(P<0.01);与上述变化相对应,与模型组相比,各治疗组活化NF-κB、TNF-αmRNA、IL-1βmRNA表达和DAI、CMDI及TDI均明显降低(P<0.05或P<0.01),电针组和T&L组上述6指标优于TLR4mAb组和LY294002组,活化NF-κB与TNF-αmRNA及IL-1βmRNA表达呈正相关(r1=0.579,P<0.05;r2=0.561,P<0.05)。结论电针足三里穴能显著降低实验性溃疡性结肠炎大鼠的NF-κB活性及TNF-αmRNA、IL-1βmRNA表达,从而减轻结肠组织损害程度,这与其阻断TLR4/NF-κB和PI3K/AKT/NF-κB信号通路有密切关系。 相似文献
738.
随着造船业飞速发展,大量高厚度、高强度、高韧性的钢板被应用于大型集装箱船的上甲板区域。EH47是工业革新的最新成果,它的屈服强度高,被使用于万箱级集装箱船的上甲板区域。某船厂10000 TEU船舱口围钢板与舾装件角焊缝发生开裂,通过有限元计算出裂纹发生的可能性,并分析了开裂发生的原因,针对结构特点和材料特点,采用CO2气体保护焊焊补,通过选用合理的焊丝、预热温度、焊后保温等措施来防止裂纹的产生。 相似文献
739.
Seyed Milad Mousavi Bideleh Viktor Berbyuk Rickard Persson 《Vehicle System Dynamics: International Journal of Vehicle Mechanics and Mobility》2016,54(8):1053-1076
Pareto optimisation of bogie suspension components is considered for a 50 degrees of freedom railway vehicle model to reduce wheel/rail contact wear and improve passenger ride comfort. Several operational scenarios including tracks with different curve radii ranging from very small radii up to straight tracks are considered for the analysis. In each case, the maximum admissible speed is applied to the vehicle. Design parameters are categorised into two levels and the wear/comfort Pareto optimisation is accordingly accomplished in a multistep manner to improve the computational efficiency. The genetic algorithm (GA) is employed to perform the multi-objective optimisation. Two suspension system configurations are considered, a symmetric and an asymmetric in which the primary or secondary suspension elements on the right- and left-hand sides of the vehicle are not the same. It is shown that the vehicle performance on curves can be significantly improved using the asymmetric suspension configuration. The Pareto-optimised values of the design parameters achieved here guarantee wear reduction and comfort improvement for railway vehicles and can also be utilised in developing the reference vehicle models for design of bogie active suspension systems. 相似文献
740.
Yuan Yao Guosong Wu Yousef Sardahi 《Vehicle System Dynamics: International Journal of Vehicle Mechanics and Mobility》2018,56(2):297-318
In this paper, we study a multi-objective optimal design of three different frame vibration control configurations and compare their performances in improving the lateral stability of a high-speed train bogie. The existence of the time-delay in the control system and its impact on the bogie hunting stability are also investigated. The continuous time approximation method is used to approximate the time-delay system dynamics and then the root locus curves of the system before and after applying control are depicted. The analysis results show that the three control cases could improve the bogie hunting stability effectively. But the root locus of low- frequency hunting mode of bogie which determinates the system critical speed is different, thus affecting the system stability with the increasing of speed. Based on the stability analysis at different bogie dynamics parameters, the robustness of the control case (1) is the strongest. However, the case (2) is more suitable for the dynamic performance requirements of bogie. For the case (1), the time-delay over 10?ms may lead to instability of the control system which will affect the bogie hunting stability seriously. For the case (2) and (3), the increasing time-delay reduces the hunting stability gradually over the high-speed range. At a certain speed, such as 200?km/h, an appropriate time-delay is favourable to the bogie hunting stability. The mechanism is proposed according to the root locus analysis of time-delay system. At last, the nonlinear bifurcation characteristics of the bogie control system are studied by the numerical integration methods to verify the effects of these active control configurations and the delay on the bogie hunting stability. 相似文献