Effect of ABCA1-V771M polymorphism on plasma lipid levels and its relationship with coronary atherosclerotic heart disease

Objective To explore the risk association of ABCA1-V771M polymorphism with coronary heart disease (CHD) in Hart nationality in Northwest of China. Methods With case-control study, ABCA1-V771M polymorphism was detected in 204 unrelated Hart nationality people in Northwest of China, and all the subjects by coronary angiography were grouped into 106 cases and 98 controls. The genotypes and alleles frequency distribution of ABCA1-V771M polymorphisms were analyzed by PCR-RFLP analysis, and the clinical statistics of serum lipids were compared and its effects of ABCA1-V771M polymorphism on the plasma lipid levels and coronary atherosclerotic heart disease were analyzed. Results The genotypic frequencies of ABCA1-V771M polymorphism matched well under Hardy-Weinberg equilibrium (P>0.05), V and M allelic frequencies were 33.3% and 66.7%. In comparison with VV VM genotype carriers, MM genotypes carriers had much lower plasma levels of HDL-C (P<0. 001) and much higher plasma levels of TG (P<0. 05). M allelic frequency in CHD group was significantly higher than V allelic frequency (P<0. 05). M allele was related with more severity of atherosclerosis in the coronary artery than V allele (P<0.05). However, there was no obvious difference in the incidence of AMI among carriers with three genotypes of ABCA1-V771M polymorphism (P>0.05). Conclusion ABCA1-V771M polymorphism was not only associated with the plasma levels of HDL-C and TG, but also related to the susceptibility and severity of coronary atheroselerotic heart disease. Moreover, M771 allele appeared to be atherogenie among Han population in Northwest of China.     

饲料加硼对摄入过量氟的实验大鼠骨损伤的预防作用

目的探讨饲料加硼对过量氟摄入的大鼠骨损伤的预防作用。方法24只4-5周龄Sprague-Dawley(SD)大鼠分为:对照组(喂饲基础饲料,饮蒸馏水)、过量氟组[喂饲基础饲料,饮含100mg/LF-(氟化钠221mg/L的蒸馏水)]、硼预防组(喂饲加硼饲料,饮含100mg/LF-的蒸馏水)。实验3月后测量大鼠血清氟、硼含量及血清碱性磷酸酶(alkaline phosphatase,AKP)活性、骨氟和骨总RNA含量、胫骨纵径横径和干重及骨密度(bone mineral density,BMD),并检测大鼠股骨生物力学特性。结果和对照组比较,过量氟组大鼠血清氟、骨氟含量和血清AKP活性显著增高;骨总RNA含量、全身骨骼平均BMD和胫骨BMD降低;胫骨纵径、横径和干重减小;股骨最大负荷减低,最大形变增加。相比过量氟组,硼预防组大鼠血清氟和骨氟含量及AKP活性明显下降;骨总RNA含量、全身骨骼平均BMD、腰椎和胫骨BMD显著增高;胫骨纵径、横径和干重,股骨最大负荷明显增加。3组大鼠血清硼含量无显著性差异。结论大鼠摄入过量氟可出现明显的骨损伤,饲料加硼对此有一定的预防作用。     

Moiré条纹密度对条纹图噪声及相位混频的影响

分析了Moiré条纹密度对条纹图噪声及相位混频的影响,提出了一种调整Moiré条纹密度的方法以有效减少条纹图噪声与包裹相位图噪声,并消除条纹过密产生的相位混频。试验测量表明,该方法能够获得可靠的测量结果,具有较好的测量精度。     

风积沙的工程力学性质试验研究

结合毛乌素沙漠沙样,对风积沙的工程力学性质进行了系统的试验研究。试验结果表明:风积沙的压实可采用常规的击实试验方法和振动密实法,压实效果受颗粒级配、含水量、荷载大小、振动频率及振幅等多种因素影响;风积沙的内摩擦角与压实度之间呈线性变化规律,颗粒级配是主要影响因素,含水量影响较小;风积沙的室内回弹模量和加州承载比与压实度之间大致呈非线性增大规律,在某一压实度区间增大的幅度非常小。     

恒温热源条件下实际回热式布雷顿循环的功率密度特性

用有限时间热力学方法分析恒温热源条件下实际回热式布畦顿循环的功率密度特性,计入工质与高,低温侧换热器的热阻损失,压气机,涡轮机的不可逆压缩和膨胀损失,以及管路系统中的压力损失,导出了功率密度与压比间的解析式,并通过数值计算将对应于最大功率密度时的一些参数与对应于最大功率时的同样参数进行了比较。     

轨迹数据驱动的单点信号交叉口运行效率评价方法

为解决信号交叉口运行效率评价方法偏理论化、实用性不强等问题,以出租车、公交车、驾图(车联网)多源GPS轨迹数据为基础,充分利用车辆减速、停车、加速等连续速度变化特征及位置信息,提出交叉口个体车辆排队长度、通行时间、停车次数等交通参数提取技术.基于此,构建以信号交叉口运行指数为一级指标,车辆平均通行时间,第95％分位排队...     

细粒土路基平衡密度状态分析

为掌握细粒土路基的平衡密度状态及其变化原因,统计分析9条高速公路路床顶部的压实度和含水率检测资料,对3条黄泛区高速公路路基的压实度、含水率以及1条高速公路的路基模量进行全断面深度检测,并开展非饱和细粒土的湿化试验和弹性恢复试验。现场实测发现：在役路基除了实测含水率较最佳含水率有0~13.8%的增加外,相应的压实度出现了0~10%的线性衰减;其中,路床区、上路堤以及受水位波动影响较大的路基底部的压实度降低十分明显,而下路堤上部区域压实度基本维持不变甚至有所增大;路基压实度的变化与土的含水率密切相关。非饱和土三轴试验结果表明：土体湿化过程中,吸水导致体积膨胀和压实度衰减;当路床土吸湿至平衡湿度（含水率为18%）时,土体压实度降低5.07%。弹性恢复试验结果表明：压实路基土因变形恢复导致路基密度衰减;低含水率、高压实度和低上覆荷载条件下的弹性恢复较大,压实路床土弹性恢复导致的压实度降低值最大为0.5%;综合湿化和弹性恢复结果来看,两者占黄泛区路床区压实度衰减总量（约7%）的79.6%;此外,路基剪切模量的原位实测值较相同物理状态下的室内重塑土结果平均高出了60.64%,表明运营多年的高速公路路基土具有一定的结构性。因此,既有路基的评价应该同时考虑路基湿度增加、密度降低以及土体结构性等综合因素。     

不同RAP掺量下就地热再生沥青混合料空隙率优选分析

依托福建省某高速路面预防性养护工程,采用最大理论密度线理论设计了再生沥青混合料级配,通过马歇尔试验研究了RAP料在86%、90%、94%掺量下再生沥青混合料空隙率的变化,并基于二次回归方程建立了不同RAP掺量与再生沥青混合料空隙率之间的回归方程,说明了不同RAP掺量与空隙率之间的变化趋势。研究结果表明:随着RAP料掺量增加,再生沥青混合料空隙率在逐渐降低;当再生沥青混合料空隙率控制在4%时,RAP料掺量约为89%。     

Comparative analysis of household car,motorcycle and bicycle ownership between Osaka metropolitan area,Japan and Kuala Lumpur,Malaysia

The interactions among different types of vehicle ownership including car, motorcycle and bicycle are examined by developing simultaneous vehicle ownership models in this study. Large scale person trip survey data for Osaka metropolitan area, Japan and Kuala Lumpur, Malaysia are used for empirical analysis. The results suggest that population density at residential area significantly and negatively affects car ownership for both areas, and that the effects are larger for Osaka metropolitan area than for Kuala Lumpur. Also, bicycle ownership becomes higher at higher population density area for Osaka area, while higher at lower population density area for Kuala Lumpur, which represents the different usage patterns of bicycle between the two areas.

光面爆破技术在城市地铁隧道施工中的应用

文章从光面爆破机理、光面爆破技术中各主要参数的确定,以及光面爆破在实际工程中的应用几个方面出发,以深圳地铁安-侨区间隧道硬岩段施工为例,研究分析了如何利用光面爆破技术来提高城市地铁浅埋暗挖法的光爆效果,特别是近距离穿越重要建(构)筑物时如何有效进行光面爆破。