Effect of ABCA1-V771M polymorphism on plasma lipid levels and its relationship with coronary atherosclerotic heart disease

Objective To explore the risk association of ABCA1-V771M polymorphism with coronary heart disease (CHD) in Hart nationality in Northwest of China. Methods With case-control study, ABCA1-V771M polymorphism was detected in 204 unrelated Hart nationality people in Northwest of China, and all the subjects by coronary angiography were grouped into 106 cases and 98 controls. The genotypes and alleles frequency distribution of ABCA1-V771M polymorphisms were analyzed by PCR-RFLP analysis, and the clinical statistics of serum lipids were compared and its effects of ABCA1-V771M polymorphism on the plasma lipid levels and coronary atherosclerotic heart disease were analyzed. Results The genotypic frequencies of ABCA1-V771M polymorphism matched well under Hardy-Weinberg equilibrium (P>0.05), V and M allelic frequencies were 33.3% and 66.7%. In comparison with VV VM genotype carriers, MM genotypes carriers had much lower plasma levels of HDL-C (P<0. 001) and much higher plasma levels of TG (P<0. 05). M allelic frequency in CHD group was significantly higher than V allelic frequency (P<0. 05). M allele was related with more severity of atherosclerosis in the coronary artery than V allele (P<0.05). However, there was no obvious difference in the incidence of AMI among carriers with three genotypes of ABCA1-V771M polymorphism (P>0.05). Conclusion ABCA1-V771M polymorphism was not only associated with the plasma levels of HDL-C and TG, but also related to the susceptibility and severity of coronary atheroselerotic heart disease. Moreover, M771 allele appeared to be atherogenie among Han population in Northwest of China.     

自动液位监控系统的设计

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软刚臂单点系泊装置监测预报系统的设计及实现

为进一步保障浮式生产储油装置(FPSO)的作业安全,通过海洋环境条件测量、FPSO运动和单点系泊系统(SPM)状态监测以及理论计算等手段,实现了软刚臂单点系泊监测预报系统的方案设计,并成功应用于渤海油田。经现场应用验证,该系统能够实现对FPSO及SPM运行情况的监测,为作业者提供FPSO操作指导及预警,有效的降低了作业风险。     

深圳地铁单程票流失算法研究

根据深圳地铁单程票流通特点,将运营中的单程票流失划分成两大类,并依据其在流通中的业务类型,通过卡信息记录集来确定流失种类。应用数据库知识和数据挖掘技术,提出这两类单程票流失的算法。     

遥控单索无动力开闭抓斗技术分析

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一种空压机自动变频系统

利用自动变频技术对空压机控制系统进行自动化改造,提出了改造的硬件方案和软件方案,该系统使用方便,可靠性高,并能降低能耗。     

RFID技术在供应链中的应用

介绍了RFID的发展历程和关键技术,对电子标签的应用及工作原理、优点等进行了阐述.从信息与利润共享入手论述了电子标签对供应链产生的影响,对RFID技术在供应链中的应用做了分析和预测,并结合中国实际对如何发展RFID在物流供应链中的应用提出了一些建议.     

基于单片机的打标机导向控制系统设计

设计了一套基于微处理机控制单元(microprocessor control unit)气动打标机导向控制系统,该系统具有汉字及字符打印功能.该文介绍了系统的硬件组成和软件设计思想.此系统易操作、流程清晰.     

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为评估重庆两江大桥单索面斜拉桥正交异性钢桥面板疲劳设计参数的合理性,对由盖板、板肋和横隔板组成的箱形正交异性钢桥面板模型进行了疲劳试验和有限元分析.基于应力等效方法,对桥面板、横隔板与纵肋三向交叉部位,进行了竖向和横向双向加载试验、等效实桥疲劳应力幅值2 000万次作用疲劳试验,在此基础上,分析了3种开孔方式、构造细节、横隔板厚度及铺装层厚度等因素对疲劳性能的影响.研究结果表明:横隔板厚度和铺装层厚度对疲劳性能的影响很大;与钥匙形和圆形相比,苹果形开孔结构的主拉应力最小,为13.7 MPa,疲劳性能最优.建议开口肋正交异性板构造横隔板厚度大于16 mm,并采用苹果形开孔方式.     

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