水中悬浮隧道交通荷载模拟方法研究

为研究水中悬浮隧道交通荷载的合理模拟方法以及交通荷载对隧道结构的影响,借鉴铁路、公路交通荷载的模拟方法,综合考虑车辆轮载、路面不平度、行车速度以及外部激励荷载等影响因素的共同作用,提出水中悬浮隧道交通荷载的模拟表达式。通过数值模拟计算,分析悬浮隧道交通荷载的变化特征,并研究不同交通荷载模拟方法对悬浮隧道结构振动位移响应的影响。结果表明:文章提出的交通荷载模拟方法计算结果符合移动振动荷载的波动性和周期性特征。在对结构振动位移响应影响方面,固定均布荷载相当于静载,移动集中荷载和移动振动荷载时的位移变化幅值相对固定均布荷载时的大且影响相似,但移动振动荷载时的振幅稍大,体现了交通荷载中动荷载部分对结构振动位移响应的影响,更适合用来模拟悬浮隧道中的交通荷载。     

基于小波和粒子群算法的HEV行驶状况辨识方法研究

针对混合动力汽车(HEV)行驶状况(道路坡度和整车载荷)变化难以有效识别,导致驱动系统控制策略不能有效满足驾驶员意图问题,以混联式HEV为研究对象,提出了基于小波滤波和粒子群算法的HEV行驶状况辨识方法。首先建立了汽车行驶状况辨识模型,采用最小二乘法确立了优化目标函数,其次研究了基于小波滤波和粒子群算法的HEV行驶状况辨识原理,最后进行了行驶状况粒子群智能算法辨识试验。在采集实车数据的基础上,对实车数据进行小波滤波,并运用行驶状况辨识方法对道路坡度和整车载荷进行了辨识,并对辨识结果进行小波滤波,结果表明,试验工况下整车载荷辨识的相对误差绝对平均值为2.71%,道路坡度辨识的相对误差绝对平均值为3.85%,验证了所提出方法的有效性。     

面向控制的SCR催化转化器温度模型

为了建立面向控制的SCR催化器温度模型,根据能量守恒和质量守恒方程并考虑热平衡中所涉及的换热过程不同,建立了4种SCR催化器温度的数学模型,并利用Matlab/Simulink构建图形化的计算模型。采用柴油机欧洲稳态循环(ESC)和欧洲瞬态循环(ETC)条件下的台架实测数据对模型进行检验,基于最大离散程度、拟合度和计算时间3个指标对模型进行评价和比较。结果表明,考虑催化器与废气和周围环境对流换热的温度模型具有良好的预测精度和实时性,更适合用于SCR控制策略。     

基于ARENA的双车道超车视距设计风险评价

通过计算机仿真软件ARENA模拟双向两车道路段上不同的超车视距长度下的超车行为,并建立风险指标。风险指标主要根据超车动作结束时,超越车与对向车辆间的最短时间距离确定。一共确定了六个风险等级,用于评价不同设计时速下的各种PSD长度的风险。利用此方法可以很直接的评价超车视距设计的优劣。     

北京市商业区可达性研究

为建立商业区可达性计算方法,并为未来商业区的选址、设计提供参考,选取北京市较为典型的5个商业区为研究对象,对商业区的特点进行了分析。从理论上探讨了计算商业区可达性包含的4个因素：土地利用、交通系统、时间因素以及个体因素。借鉴潜能模型,提出了可达性理论模型,并给出具体的可达性计算公式。以北京市5个商业区中18个大中型商场为例,计算可达性以及各区域到达这些商业区的可达性分布。     

公交通行能力约束的智能调度优化模型

公交通行能力是解决城市交通拥堵问题、促进城市公共交通系统高效运行的要素之一。介绍了公交通行能力的计算要素,并针对目前我国城市由于盲目调度造成的公交系统运营效率、服务水平下降的问题,提出将公交通行能力作为约束条件对公交调度进行优化。鉴于公交企业制订调度方案时需兼顾公交服务水平和企业效益,将智能调度的目标确定为候车时间满意度、候车空间满意度、车内舒适满意度和企业满意度加权平均值最大,并给出了相应的计算方法。最后讨论了利用遗传算法对模型进行求解的过程。     

Effects of rosiglitazone on rabbit atherosclerosis

We sought to validate magnetic resonance imaging(MRI) for documenting the effects of rosiglitazone on rabbit atherosclerosis and the possible mechanism by treatment on the lesions.24 New Zealand white rabbits were randomly divided into normal group, control group and treatment group.After 4 weeks, all rabbits underwent MRI.After examination, the number of circulating endothelial progenitor cells(EPCs) and level of lipid, glucose, nitric oxide(NO) and superoxide anion(O-2·) were measured.MRI demonstrated the regression of atherosclerotic lesions by rosiglitazone which has good correlation with histopathology.Treatment not only increased the level of EPCs and NO, but also raised the ability of inhibition of O2-·.MRI is a promising noninvasive technology to detect the effects of therapeutic interventions.Rosiglitazone slows the progression of atherosclerosis that may in part attribute to its improvement of mobilization of EPCs and the reduced oxidative stress.     

A data model applied to the knowledge-based ICAS

Image-guided computer aided surgery system (ICAS) contributes to safeness and success of surgery operations by means of displaying anatomical structures and showing correlative information to surgeons in the process of operation. Based on analysis of requirements for ICAS, a new concept of clinical knowledge-based ICAS was proposed. Designing a reasonable data structure model is essential for realizing this new concept. The traditional data structure is limited in expressing and reusing the clinical knowledge such as locating an anatomical object, topological relations of anatomical objects and correlative clinical attributes. A data structure model called mixed adjacency lists by octree-path-chain (MALOC) was outlined, which can combine patient's images with clinical knowledge, as well as efficiently locate the instrument and search the objects' information. The efficiency of data structures was analyzed and experimental results were given in comparison to other traditional data structures. The result of the nasal surgery experiment proves that MALOC is a proper model for clinical knowledge-based ICAS that has advantages in not only locating the operative instrument precisely but also proving surgeons with real-time operation-correlative information. It is shown that the clinical knowledge-based ICAS with MALOC model has advantages in terms of safety and success of surgical operations, and help in accurately locating the operative instrument and providing operation-correlative knowledge and information to surgeons in the process of operations.     

大骨节病病因与发病机制的研究进展及其展望

大骨节病是一种地方性、畸形性骨关节病,至今原因未明,目前以我国西部地区最重,尚无有效治疗措施。本文依据国内外有关研究,总结分析了大骨节病三种病因假说的研究进展及其尚待解决的问题,结合作者及其研究团队近年来的研究进展,提出大骨节病除经典的软骨细胞坏死外还表现有软骨细胞过度凋亡和"去分化",大骨节病软骨细胞差异表达基因、血清蛋白表达谱及短串联重复序列多态性不同于病区内外正常人与骨关节病。确定大骨节病软骨细胞坏死发生的基因与蛋白标志物,以及何种环境因素如何与大骨节病易感基因相互作用而选择性的损伤深层软骨细胞及其干预措施,是未来大骨节病病因发病机制研究的重要目标。