警惕安全驾车杀手的袭击

驾驶员在行车途中往往容易遭遇被他人挑衅或者挑衅他人的行为,挑衅行为属于一种认知干扰,会分散驾驶员的注意力,甚至酿成交通事故,造成人员伤亡。     

道路线形设计与交通安全的关系

影响交通安全的因素,包括人、车、路、环境和管理等多方面,其中驾驶员素质不高,操作技能差、安全意识不强,是导致我国交通事故的主要因素,但是仅仅将事故的原因归结为人的因素是不客观的。道路作为车辆的载体和行驶的基础,其设计的安全性对交通安全有很大的影响。据统计,有10％～20％的交通事故与道路条件有直接关系,     

Construction of lentivirus vectors carrying alphastatin gene and its secretion expression in human umbilical vein endothelia cells

Objective To construct lentivirus vectors carrying alphastatin gene, test its secretion expression in human umbilical vein endothelia cells (HUVECs) and observe its effects on growth, migration and tube formation of HUVECs. Methods We constructed recombinant lentivirus vectors of NT4-alphastatin fusion gene containing neurotrophin-4 signal peptide, pro-region sequences and alphastatin, then transfected the recombinant lentivirus vectors into HUVECs to obtain secretory protein alphastatin and test its anti-angiogenic activities in vitro. Results Our data showed that recombinant self-inactivating lentivirus vectors of NT4-alphastatin were successfully constructed, and stable NT4-alphastatin transduced HUVECs were capable of sustainably secreting alphastatin which significantly suppressed HUVECs migration and differentiation but not VEGF-induced proliferation. Conclusion This report represents the first time on the use of lentivirus-based vectors to deliver alphastatin, the endogenous angiogenesis inhibitor, and reveals the potential utility of anti-angiogenic gene therapy with lentivirus vectors for treating cancer.     

健康新理念 铺就新高速——绕越工程开展“四健康”活动的探索和研究

为铺筑新高速,树立健康新理念,南京绕越高速围绕优质、高效建好绕越工程和培养造就勤政、廉政干部的目标,开展廉政文化"四健康"活动即健康思想高情操、健康工作高效率、健康生活高质量、健康文化高品位活动,有效促进了工程建设。     

跨越50年 MINI COUNTRYMAN

<正>Mini问世时的英国人做梦也想不到,50多年后德国人会把它发展成这个样子。宝马的动作好快!上个月还是在北美车展现场看到的为Countryman上市预热的Beachcomber概念车,想不到2月未过,Countryman就已经正式发布了。作为Mini旗下的第四款车型,也是Mini的首款跨界车,Countryman在工程技术上的变     

基于人-车-路综合影响的期望速度研究

基于汽车性能、驾驶人心理生理状况、道路横断面宽度以及路段限速条件对驾驶人行车速度进行详细分析,通过对人-车-路综合影响下的期望速度进行研究表明:期望速度与道路等级及设计速度并无直接关系而且也不是定值。论文探讨并提出了考虑人-车-路综合影响的期望速度计算方法,可以为运行车速预测模型的研究以及高速公路限速管理提供参考。     

Effects of systemic domestic recombinant human erythropoietin on HIF-1α expression in the retina in a rabbit model of acute high intraocular pressure

Objective To observe the expression of hypoxia inducible faetor-1α (HIF-1α) in the retina of rabbits with acute high intraocular pressure and to investigate the mechanism of systemic domestic recombinant human erythropoietin (rhEPO) protecting the retina from ischemia-reperfusion injury. Methods First, control group and model group were established in rabbit eyes. The acute high intraocular pressure model was established by saline perfusion into anterior chamber, and then hypodermic injection of domestic rhEPO was made. HIF-1α protein in the retina was observed by immunohistochemical staining method on days 1, 3, 7 and 14 after retinal ischemla-reperfusion, respectively. Results No cells with HIF-la positive expression were observed in the retina of the control group. Ceils with HIF-1α positive expression in the model group outnumbered those in the control group (P < 0. 01). The resemblance pattern occurred in EPO group but its degree was slightly greater than that in the model group from day 3 after ischemia-reperfusion (P<0.05). Conclusion Domestic rhEPO can down-regulate the expression of HIF-1α in the retina with acute high intraocular pressure, which may be one of the mechanisms that rhEPO protects the retina from ischemia-reperfusion injury.     

基于人-车-路三自由度振动模型的路面平整度评价方法

为了更准确地评价路面的行车舒适性,以乘客的竖向加权加速度均方根值作为平整度评价指标,将人-车-路组成的系统简化成三自由度振动模型,依据牛顿法建立了振动微分方程,采用传递矩阵法对其进行了求解,进而建立了考虑人-车-路相互作用的路面平整度评价方法。结果表明,该评价方法能考虑不同路面类型以及公路等级的影响,对于不同等级路面的评价结果与实际情况一致,而国际平整度指数、功率谱密度和平整度标准差在部分工况下不能很好地描述路面的舒适性。     

人车碰撞事故仿真与行人保护研究

基于PC-Crash软件建立了行人汽车碰撞模型.综合考虑人车碰撞过程中行人身高、步行速度、车速、人车碰撞位置等因素及其统计特征,利用Matlab软件随机生成行人与汽车碰撞工况作为PC-Crash行人汽车碰撞模型输入,进行了大量的仿真,总结出事故发生后人体头部与车体前部碰撞点的分布规律,为汽车在行人保护设计方面提供参考.     

大型公共建筑的交通组织探讨

随着城市规模的扩大,涌现出越来越多的大型公共建筑。大型公共建筑对周边交通组织有较大影响,如组织不当,易引发多种交通问题。该文提出大型公共建筑的交通组织原则,对大型公共建筑进出口及平面布置等进行了探讨。