p53 codon72基因多态性与宫颈癌发病风险的meta分析

目的利用meta分析的方法系统评价p53codon72多态性与宫颈癌发病风险的关系。方法检索1998~2004年Medline、Elsevier、Evidence-Based Medicine Reviews、Ovid、中国期刊网、维普科技期刊数据库等,语种不限。并追溯检索获得的已发表文献及我们研究组未发表的文献。纳入标准:涉及p53codon72基因型频率的独立病例对照研究,各文献研究方法相似,有综合的统计指标。剔除不符合纳入标准的,重复研究报告及数据不完整的文献。用Rev-Man4.2软件进行统计分析。结果将总研究按病理组织学类型及种族和地域进行亚组分析,亚洲人群宫颈上皮内瘤样变(CIN)亚组和欧洲人群(主要为白种人)CIN亚组分析显示与其对照组无统计学差异。亚洲人群宫颈鳞癌(SCC)亚组合并OR=1.28,95%CI=1.05~1.55。欧洲人群SCC亚组合并OR=1.45,95%CI=1.08~1.95,P<0.01,有统计学意义。结论p53codon72Arg/Arg基因型未能增加亚洲人群和欧洲人群宫颈癌前期病变发生的危险性,但与浸润性宫颈癌发病风险有正向弱相关性。     

P~（53）蛋白在人脑星形胶质细胞瘤中的表达及意义

采用免疫组化法对５０例人脑星形胶质细胞瘤组织中Ｐ５３蛋白的表达，及其与肿瘤临床病理学特征和预后的关系作了分析，结果显示：本组５０例中２２例表达阳性，阳性率占４４％，Ｐ５３蛋白主要分布在细胞核内，正常脑组织Ｐ５３蛋白表达均为阴性，且肿瘤分化程度越差，预后不良者其阳性染色愈强烈，提示Ｐ５３基因及其蛋白与人脑星形胶质细胞瘤的发生、发展密切相关，可做为判定脑肿瘤恶性程度和预后的重要指标。     

Design and model test of a soft-connected lattice-structured floating solar photovoltaic concept for harsh offshore conditions

Various types of floating solar photovoltaic (FPV) devices have been previously proposed, designed and constructed with applications primarily limited to onshore water bodies or near-shore regions with benign environmental conditions. This paper proposes a novel FPV concept which can survive harsh environmental conditions with extreme wave heights above 10 m. This concept uses standardised lightweight semi-submersible floats made of circular materials as individual modules. The floating modules are soft connected with ropes to form an FPV array. We first present the conceptual design of the floats and the connection systems, including hydrostatic, hydrodynamic, and structural assessments of the floats. To verify the motion response performance, we carried out 1:60 scaled model tests for a 2 by 3 array under regular and irregular wave conditions. From the time series and response spectra, the motion characteristics of the array and the mooring responses are analysed in detail. The proposed concept exhibits excellent performances in terms of modular motions with limited wave overtopping and no contact is observed between adjacent modules under the extreme wave conditions. The findings of this study can serve as a valuable reference to developing reliable and cost-effective FPV technologies for offshore conditions.