免疫组化检测葡萄胎组织P53突变蛋白在预测葡萄胎恶变中的意义

用免疫组化ＡＢＣ法及Ｐ５３单克隆抗体Ｄ０－７检测了３２例葡萄胎首次清宫标本。结果表明：未恶变的９例Ｐ５３染色阳性率为３３．３３％，强度均为（＋），发生恶变的２３例Ｐ５３染色阳性率为８２．６％，强度为（＋）１０例，（＋＋）６例，（＋＋＋）３例，二者差别明显，中强以上阳性均发生恶变。可见，检测葡萄胎首次清宫标本的Ｐ５３突变蛋白，有望作为预测葡萄胎恶变的一项指标。     

基于ANSYS软件的功率器件寄生电容建模分析

大功率变频器中电磁兼容问题是不可被忽视的。其中传导干扰会影响输出波形,降低电能质量。IGBT的寄生电容对于传导干扰有很大影响,本文对功率器件中IGBT的寄生电容形成原理和计算方法进行了分析。在此基础上运用有限元仿真软件ANSYSQ3D建立了基于英飞凌FZ1200R17HE4较为精确的模型。最后通过实验测量与仿真结果进行对照,仿真结果很好的对应了实验结果,本文所提方法能更准确的建立IGBT相关杂散参数的模型。     

Transport and nation‐state governments: a global review

The review undertaken in this paper shows how, at the beginning of 1988, nation‐states of the world allocated ministerial responsibilities for the important function of transport. A total of 118 countries are examined, compared with 111 in 1982 (Transport Reviews, Vol. 2, No. 4) and 115 in 1985 (Transport Reviews, Vol. 5. No. 1). The analysis reveals an increase in the number of ministers solely responsible for one mode of transport, and notes an increase in the number of designated ministers for tourism. The paper goes on to examine the two main duties of ministers of transport: safety and economic regulation; and of the increasing need for closer international co‐operation as new transport technology, the growing demand for travel and expanding world trade make our world ‘an even more local village’ in the decades to come.     

工业海洋大气环境下焊接耐候钢Q355NHD腐蚀后力学性能研究

随着钢结构桥梁建设需求不断提高、应用日益广泛,耐候钢以其优良的耐候性能,从材料层面为钢桥防腐提供了一种理想方案;但是,由于中国应用耐候钢的时间较短,耐候钢在某些自然环境下的适用性尚未得到充分论证,对其腐蚀后基本力学性能和疲劳性能的认识尚不完善。为此,以钢桥常用的Q355NHD焊接耐候钢及其对接焊缝为研究对象,针对中国滨海城市常见的工业海洋大气环境,通过周期浸润加速腐蚀试验探讨Q355NHD的耐候性能,并对腐蚀后Q355NHD的单调拉伸性能和疲劳性能开展试验研究。基于形貌观察、基体扫描、锈层分析和腐蚀深度计算等多角度分析,发现在模拟工业海洋大气环境下,Q355NHD尽管会形成具有一定致密性的锈层,但其腐蚀速率等宏观指标相比于普通钢并不突出。腐蚀后单调拉伸试验结果表明:腐蚀8周(等效于青岛受工业污染的海洋大气环境下自然腐蚀20年)后Q355NHD母材试件的屈服强度和抗拉强度分别下降8.1%和7.2%,对接焊缝试件的屈服强度和抗拉强度分别下降14.1%和12.5%。腐蚀后疲劳试验结果表明:腐蚀8周后Q355NHD母材试件和对接焊缝试件的设计疲劳强度分别下降35.6%和30.3%,为317.9 MPa和211.0 MPa,但仍然满足《钢结构设计标准》(GB 50017-2017)中相应构造类别的疲劳设计要求。经与既有文献报道的Q355普通钢试验结果对比,表明尽管Q355NHD在工业海洋大气环境中未表现出良好的耐腐蚀性能,不建议按免涂装使用,但其力学性能在不同批次试验结果中处于较高水平,可以视为一种优质的Q355钢材。     

地质构造和地形对N.Barton岩质评定系数Q值的影响分析

挪威岩土所Barton等人给出的岩质评定系数Q值计算式,从岩体的完整性、结构面发育程度、地下水和地应力的影响等方面,全面地反映了岩体的工程地质状况和水文地质状况,定量地反映了围岩质量的好坏,但对宏观地质构造及地形地貌的影响考虑相对较少.文章通过理论分析和数值计算,提出了三个修正系数,即褶皱影响系数Kfo、断层影响系数Kfa以及地形影响系数Ktf,并针对具体工程给出了相应的取值范围,对Q值进行了修正,反应了工程地质构造、地形地貌对Q值的影响程度,使其表达更为准确.     

P53与P21(WAF1/CIP1)在甲状腺癌中的表达及临床意义

目的　探讨 P53、P2 1 (WAF1 /CIP1 )基因与甲状腺癌的发生、发展及预后的关系以及它们的相互关系。方法　应用 S- P免疫组化技术 ,检测 60例甲状腺癌、1 0例正常甲状腺组织、1 0例结节性甲状腺肿、1 0例甲状腺腺瘤组织中 P53、P2 1 (WAF1 /CIP1 )的表达。结果　 P53、P2 1(WAF1 /CIP1 )阳性反应仅见于甲状腺癌 ,其阳性率分别为 53.3%、41 .7% ;P53阳性率在未分化癌、有淋巴结转移或 、 期病例中增高 (P <0 .0 5) ;但 P2 1 (WAF1 /CIP1 )阳性率在未分化癌、有淋巴结转移或 、 期病例中降低 (P <0 .0 5) ;P53表达与 P2 1 (WAF1 /CIP1 )表达关系密切(P <0 .0 5)。结论　 P53突变、P2 1 (WAF1 /CIP1 )缺乏均与甲状腺癌发生有关 ;P2 1 (WAF1 /CIP1 )在甲状腺癌中表达主要依赖于 P53;P53、P2 1 (WAF1 /CIP1 )在甲状腺癌中表达的变化可用于评估其生物学行为和判断预后     

卫星定位通信系统中互调干扰的抑制

本文提出了大卫星定位通信系统中采用四相扩频（Ｑ－ＳＳ）技术,并沿用瑞士人给出的卫星转发器功率放大器的数学模型,推导了Ｑ－ＳＳ信号通过卫星转发器后输出的表示式;通过进一步分析发现了采用Ｑ－ＳＳ技术可以在信号解扩后完全消除三阶和五阶的互调干扰。     

THE DETECTION OF P53 GENE IN HUMAN CERVICAL CARCINOMA WITH AND WITHOUT HUMAN PAPILLOMAVIRUS INFECTION

ＴＨＥＤＥＴＥＣＴＩＯＮＯＦＰ５３ＧＥＮＥＩＮＨＵＭＡＮＣＥＲＶＩＣＡＬＣＡＲＣＩＮＯＭＡＷＩＴＨＡＮＤＷＩＴＨＯＵＴＨＵＭＡＮＰＡＰＩＬＬＯＭＡＶＩＲＵＳＩＮＦＥＣＴＩＯＮＳｕｎＹｉ（孙毅）；ＳｉＬｕｓｈｅｎｇ（司履生）ＳｕｎＹｉ；ＳｉＬｕｓｈｅｎ...     

THE EXPRESSION OF P53 PROTEIN AND P21WAFl/cipl/sdil IN GASTRIC CARCINOMA

Ａｂｎｏｒｍａｌｉｔｉｅｓｏｆｔｈｅｐ5 3ｇｅｎｅｒｅｐｒｅｓｅｎｔｔｈｅｍｏｓｔｃｏｍｍｏｎｇｅｎｅｔｉｃａｌｔｅｒａｔｉｏｎｓｉｎｈｕｍａｎｃａｎｃｅｒ[1] .ｐ2 1ｐｒｏｔｅｉｎｈａｓｂｅｅｎｒｅｐｏｒｔｅｄｔｏｂｅａｃｒｉｔｉｃａｌｄｏｗｎｓｔｒｅａｍｅｆｆｅｃｔｏｒｏｆｐ5 3ａｎｄａｐｏｔｅｎｔｉｎｈｉｂｉｔｏｒｏｆｃｙｃｌｉｎ ｄｅｐｅｎ ｄｅｎｔｋｉｎａｓｅ[2 ] .ＡｓａｒｅｓｕｌｔｏｆＤＮＡｄａｍａｇｅ ,ｐ5 3ｉｎ ｄｕｃｅｓｔｈｅｅｘｐｒｅｓｓｉｏｎｏｆｉｔｓｄｏｗｎｓｔｒｅａｍｇｅｎｅ :…     

Cruise activity and pollution: The case of Barcelona

One of the main causes of mortality worldwide is air pollution. To tackle this problem, local, regional and national governments have implemented policies to reduce emissions from industrial and on-road sources. However, when these policies are being designed, shipping emissions are often overlooked. There has been a drastic increase in the demand for cruises and its economic relevance is also growing in port-cities. Barcelona is Europe’s leading cruise port, and it is located near the centre of the city. In this context, this paper analyses the impact of cruise ships in the air quality of the entire city of Barcelona using a dataset with information about pollutants and the number of cruises arriving to the port. We show that there is a direct impact between cruises staying at the port and city pollution. Additionally, the size and age of the cruise also affect air quality. The larger (or newer) the cruise is, the higher the emission generated. Moreover, our simulations show that the whole city is affected by these emissions.