原癌基因c-erbB2和EGFR表达与大鼠肺纤维化的相关性

目的研究原癌基因c-erbB2和肺表皮生长因子受体(EGFR)的表达与大鼠肺纤维化的相关性,探讨肺纤维化的发生机制。方法采用博莱霉素气管注射法制造鼠肺纤维化模型。30只Wistar大鼠随机分为模型组和对照组,分别于第1、14、28天处死大鼠5只并留取标本,采用免疫组化SP法检测在不同程度肺纤维化条件下c-erbB2和肺内源性EGFR的表达,分析其与肺纤维化的相关性。结果①模型组c-erbB2和EGFR表达在各时间点均与对照组有统计学差异(P<0.01);②模型组c-erbB2表达1d最显著,EGFR表达28d达到顶峰,与同组其他时间点均有统计学差异(P<0.01);③模型组c-erbB2和EGFR水平在第14天与最低水平组(分别为第28天和第1天)比较有统计学差异(P<0.01);④模型组c-erbB2和EGFR表达与肺纤维化程度密切相关(相关系数r分别为-0.835和0.77,P<0.01)。结论 c-erbB2活化的同时,EGFR表达也逐渐增强,且c-erbB2、EGFR的活化水平与肺纤维化程度密切相关;c-erbB2和EGFR激活可能参与了肺纤维化的发生。     

基于物元理论的地铁消防系统安全可靠性评价

地铁消防系统的安全可靠性是地铁安全的重要性内容。本文综合考虑地铁消防系统的特征指标,以物元分析对地铁消防系统安全可靠性进行评价,根据评价结果找出其薄弱环节及管理重点。通过具体案例研究,知物元分析不仅可以得出评价对象的评价等级,还可以对同一等级的对象进行细致地评判,从而说明物元分析法在地铁消防系统安全可靠性评价中优于层次...     

砂土宏观力学特性与细观结构的相关性试验研究

通过无标点变形量测系统分析桩周土变形场,确定剪切破坏区和显微细观观测点.应用MiVnt系统分析加荷过程中土细观参数变化,细观参数(1+e)/e3、颗粒偏心度与基础位移的相关性最强;随荷载增大,1#,2#点孔隙比下降呈负相关关系,引起剪缩特征,3#点呈正相关关系而剪胀应力松弛;1,2,3#点颗粒定向性均增高呈正相关性,表明颗粒分布有序性减弱,土体具有非稳定性的承载形式.     

腐蚀作用下钢筋与混凝土粘结性能关联因子研究

通过分析试验数据,评价影响腐蚀作用下钢筋与混凝土之间极限粘结力的因素。研究结果表明,腐蚀作用下,各关联因子对钢筋与混凝土之间粘结力的影响大小依次为：保护层厚度、钢筋直径、钢筋等级、钢筋锈蚀率、混凝土强度。     

基于加权Kendall相关系数和序贯代理模型的有限元模型修正

为了提高桥梁结构有限元模型修正的效率和效果，提出基于加权Kendall相关系数和序贯代理模型的有限元模型修正方法。首先，建立基于目标响应误差和待修正设计参数灵敏度的加权Kendall相关系数指标，并采用凝聚层次聚类算法，合理确定待修正设计参数的数量和位置，保证待修正设计参数对目标响应具有合适的解耦能力；其次，为解决传统一次性代理模型法在构造代理模型过程中产生的欠采样或者过采样的问题，采用基于FLOLA-Voronoi通用序贯设计策略的序贯代理模型法，提高构造代理模型过程中试验设计样本的利用率和模型修正效率；最后，根据一座斜拉桥的静动力荷载试验数据进行有限元模型修正。结果表明：基于FLOLA-Voronoi算法的序贯代理模型能够合理地确定构造代理模型所需的样本数量和位置，使得在相同样本数量的情况下，序贯代理模型比一次性代理模型具有稍好的精度指标；采用加权Kendall相关系数指标的聚类方法可以得到具有合适解耦能力的待修正设计参数，使得修正前大误差目标响应的误差显著下降，小误差目标响应的误差基本都处于合理范围内，有效地降低了目标响应的整体误差；同时，有限元理论静动力响应与实测静动力响应的平均误差分别由5.56%、8.43%降低至1.87%、3.41%，并且相较于常规方法，修正精度更好，所提方法可以用于桥梁结构有限元模型修正，可得到准确的桥梁结构数值模型。     

关联效应对CaCuO2的电荷与自旋密度分布的影响

采用杂化密度泛函方法和哈垂一福克方法对CaCuO2的电荷与自旋密度的分布进行了研究．CuO2层的电子结构具有明显的二维特征．电子间的关联效应使Cu离子的自旋极化被削弱的同时，增强了O离子的自旋极化效应．     

装配式梁桥横向协同工作性能度量指标的研究

为了表征运营期间装配式梁桥的横向协同工作性能,提出了一种间接度量指标——相邻预制梁间的应变相关系数;同时建立了装配式梁桥的简化力学模型,通过推导建立了该指标的解析表达式。理论分析和数值仿真研究表明,在保证足够的样本长度条件下,交通流荷载趋向统计稳定,此时结构特性成为该度量指标的唯一影响因素,证明了该指标具备表征装配式梁桥横向协同工作性能的条件。     

极线约束下的多分辨率相关匹配算法

针对计算机视觉在几何测量应用中图像匹配特点,提出了将多分辨率和极线约束与相关法相结合的图像匹配方法。该方法采用金字塔分层和极线约束来弥补相关匹配带来运算量大的不足,克服了图像匹配中精度低的缺点。通过计算机视觉在几何测量检测系统中图像匹配的实际应用,验证了该算法具有较高的测量精度、速度及其实用性。     

Links between subjective and objective evaluations regarding the steering character of automobiles

This work presents an experiment on the relationships between subjective and objective evaluations of vehicle handling. Ten cars were examined objectively in several open-loop driving dynamics manoeuvres and subjectively by test persons in typical traffic situations. Results are extracted from a stationary test (the Slowly Increasing Steer Test), and a dynamical test (the Frequency Response Test). The subjective measurements are obtained from drivers on a rural road course via a questionnaire, which was developed to separately investigate the quantity level perception, the so-called “Niveau”, and the more qualitative “Liking”. These subjective “measurements” are embedded into a two-channel definition of “Steering Comfort” as a genus for “Steering Discomfort” and “Character”. The article concentrates on developing a statistical method for the consideration of correlations amongst the subjective/objective data. In doing so, the variance in example subjective Niveau ratings can be significantly explained by several objective quantities. Indicators for co-domains of validated discomfort characteristics and hints for endeavouring character Liking ranges are detected.     

Bolster spring fault detection strategy for heavy haul wagons

An on-board health monitoring system is proposed for heavy haul wagons in this paper including a signal-based fault detection and isolation (FDI) method and an on-line fault diagnose strategy. Such a system, to be feasible on freight wagons, must be sufficiently cheap and robust, hence the design assumes the constraint of using only two accelerometers mounted on the front left and right rear part of each carbody in a heavy haul train. This paper focuses on the detection of bolster spring fault conditions. The problem is made more complex by the modes of failure which might be expected in bolster spring nests. Types of spring failure are firstly identified and discussed covering situations of broken (shortening springs) and softening (individual spring loss from a nest or cross-section loss through corrosion). The effects of these faults and their detectability were investigated using simulations on straight and curved track and using a fully detailed model of a typical 40?t axle-load heavy haul wagon. The simulation results were then examined and compared using cross-correlation analysis and an FDI system was proposed. The FDI system introduced five possible fault indicators. Initial results indicated that it was possible to detect changes in bolster stiffness of ±25%. An on-line fault diagnoses strategy is proposed for bolster spring faults which only requires data from wagon monitoring during travel around sharp curves to detect and the occurrence of confirm faults. The functionality envisaged needs only a ‘once per trip’ monitoring site, such as a sharper curve, and is aimed at condition monitoring rather than the provision of alarms or comprehensive monitoring of all events.