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BothacquiredandcongenitalLong QTSyndrome(LQTS)ischaracterizedbypolymorphousventriculartachycardia (PMVT ) ,Torsadedepointets(Tdp)andsuddencardiacdeath (SCD) .ThemechanismsofarrhythmiasinLQTScomefromdrug mimicingLQTSmodels[1 ] .Studiesshowedthatadecreaseofinwardcurrentand /oranincreaseofoutwardcurrentduring phase 2and 3repolarization prolongaction potentialduration(APD )andincreasetransmuraldispersionofrepolarization (TDR) ,whichactsasaprimarystepforthe generationofearlyafterdepolar… 相似文献
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