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To explore the possible mechanism of osteogenesis for deciduous teeth stem cells (DTSCs) in vivo/ vitro, stem cells from goat
deciduous teeth (SGDs) were firstly isolated, induced and transplanted into immunocompromised mice. The SGDs’s mineralization
pattern and osteogenesis were compared with bone marrow messenchymal stem cells (BMMSCs) from goats. SGDs have similar osteogenic
differentiation pattern in vitro and bone-like tissue formation mechanism in vivo to BMMSCs; moreover SGDs have stronger alkaline
phosphatase (ALP) gene expression and osteopontin (OPN) gene expression levels than BMMSCs; also SGDs can form more bone-like
tissues than BMMSCs when cell-scaffold compounds are transplanted into immunocompromised mice. This pre-clinical study in
a large-animal model confirms that DTSCs may be an appropriate source of stem cells in repairing bone defects with tissue
engineering. 相似文献
2.
The aim of the study was to analyze the histologic and ultrastructural changes after maxillary sinus augmentation with simultaneous
implant placement using engineered bone graft material. In this study, calcium phosphate cement (CPC) scaffolds combined with
goat bone marrow stromal cells (BMSCs) were used to fill goat sinus floor space after maxillary sinus floor elevation with
simultaneous implant placement comparing with those not filled any grafted materials and used as controls. After a healing
period of 3 months, the goat maxillary sinus membrane was examined using light microscopy and scanning electronic microscopy.
The results showed that the connective tissue thickness and the epithelium thickness of mucosa were not statistically significant
difference between two groups. The tissue engineered bone complex might be an ideal graft for the sinus floor elevation and
have no influence on the sinus membrane under the histological and ultrastructural observation. 相似文献
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