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The present study presents a peripheral nerve injury animal model for evaluation of an implantable electrical stimulator we
designed. The evaluation was confirmed by ethological, electrophysiological and histologic study. Twenty New Zealand rabbits
were used. The left sciatic nerve was crushed with a micro-vessel clamp in all rabbits, and the stimulators were implanted
in ten rabbits. The other ten rabbits were in a control group. As compared with the implantation group, 3 and 6 weeks after
operation, the histology showed the typical pathologic atrophy by hematoxylin-eosin (HE), the motor nerve conduction velocity
(MCV) was found significantly slowed and the axon of crushed nerve at distal portion exhibited breakdown in the control group.
These results reveal that the implantable electrical stimulator was effective and was suitable for implantation in an animal
model. 相似文献
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