扑热息痛多腔体贮库式植入剂的制备及体外释放性能检测

目的以聚乳酸-羟基乙酸共聚物（PLGA）为载体,制备扑热息痛贮库式缓释体系,研究其体外释药性能。方法用微机电技术制备扑热息痛多腔体贮库式植入剂,采用高效液相色谱法检测药物的释放性能。本实验采用C18色谱柱,以甲醇-水（15：85）为流动相,检测波长为215nm,流速为0．8mL／min。结果载体形状不同,体外药物释放速率具有明显差异,外方内六边形扑热息痛植入剂缓释曲线符合Higuchi方程。结论扑热息痛多腔体贮库式植入剂制备工艺可行,载体的腔体形状对体外药物释放速度有较大影响。     

Home-to-work commuting,urban form and potential energy savings: A local scale approach to regional statistics

The link between transport energy consumption and land use patterns has been the focus of a considerable amount of academic works over the past decades. While many empirical researches are backed up with solid statistical techniques, most of them do not fully consider the influence of scale underlying empirical quantitative investigations. Using fine-scale home-to-work commuting data for Wallonia (Belgium), this paper re-evaluates Breheny’s (1995) assertion that urban structure should hold the characteristics of major cities if substantial energy savings are to be achieved. A local scale approach highlights efficient settlements in terms of transport energy consumption not only within major towns, but also within remote rural areas. Furthermore, results suggest that influencing the urban form following local energy efficient examples rather than regional ones could also yield significant gains, without an extreme policy stance of re-urbanisation in major cities.     

水利隧道仰拱磨耗案例探讨

台湾南部某水利隧道(全长3.1 km)于1930年完工通水启用后,至1959年曾打设二次水泥衬砌,而1972年隧道内壁全面敷以混凝土衬砌,直至2003年实施第一次隧道全线安全检测,并于2004年进行维修补强设计与紧急抢修工程,其后2005年、2006年分别针对隧道东、西洞口及隧道内实施第二次及第三次安全检测.藉由此隧道历年之补强与检测成果,初步探讨水利隧道之摩耗行为与程度,并进一步探讨水利隧道耐磨耗之补强设计,以供未来相关水利隧道维修补强设计之参考.     

Tail-Equivalent Linearization Method in frequency domain and application to marine structures

An extension of the Tail-Equivalent Linearization Method (TELM) to the frequency domain is presented. The extension defines the Tail-Equivalent Linear System in terms of its frequency-response function. This function is obtained by matching the design point of the nonlinear response with that of the linearized response, thus guaranteeing the equivalence of the tail probability of the latter and the first-order approximation of the tail probability of the nonlinear response. The proposed approach is particularly suitable when the input and response processes are stationary, as is usually the case in the analysis of marine structures. When linear waves are considered, the Tail-Equivalent Linear System possesses a number of important properties, such as the capability to account for multi-support excitations and invariance with respect to scaling of the excitation. The latter property significantly enhances the computational efficiency of TELM for analysis with variable sea states. Additionally, the frequency-response function of the Tail-Equivalent Linear System offers insights into the geometry of random vibrations discretized in the frequency domain and into the physical nature of the response process. The proposed approach is applied to the analysis of point-in-time and first-passage statistics of the random sway displacement of a simplified jack-up rig model.     

Book review

Abstract

In April 1983, the “Fourth World Conference on Transport Research” was held in Hamburg. For a period of four days, experts from all parts of the world discussed transport research and planning problems. The discussions were divided into eight so‐called ‘sub‐topics’. Fortunately, one of the sub‐topics, ‘Man and his Transport Behaviour’ (chaired by Moshe Ben‐Akiva, U.S.A. and Werner Brog, Federal Republic of Germany) dealt with the individual and his behaviour. This complemented the traditionally supply‐oriented thinking of the transport planners by introducing the demand component which had frequently been neglected in the past. Since the view has become increasingly widespread that transport is meant to serve people and thus that research should emphasize the (potential) users of the transport system, the number of papers submitted and presented on this sub‐topic was especially large.

However, the number of papers which could be included in the ‘Conference Proceedings’ was limited and this would have meant that a number of interesting documents could not be published. Therefore, papers on four special areas within this sub‐topic are to be published in four consecutive issues of Transport Reviews. The areas which will be dealt with are ‘Telecommunications’, ‘Non‐Motorised Transport’, ‘Special Problems in Third World Countries’ and ‘Fare Structures in Public Transport’. The papers were selected strictly according to their contents. A brief commentary in each issue explains in turn the reasons for choosing each of the four subject areas.     

基于冗余信息融合的车辆质心侧偏角估计方法

车辆质心侧偏角是表征车辆横向稳定性的重要参数之一,相关的估计方法研究可为整车稳定控制提供重要支撑.为提高车辆质心侧偏角估计效果,提出了一种基于冗余信息融合的质心侧偏角估计方法.分别建立了车辆动力学模型和运动学模型,利用容积卡尔曼滤波算法分别设计了用于车辆行驶状态估计的动力学模型估计器和运动学模型估计器,同时,分析了动力...     

统计学在近代中国的演变——从社会统计到数理统计

从19世纪末期至20世纪初期,统计学在中国完成了从传入到发展的第一个进程.在近半个世纪的时间里,中国统计学的发展浓缩了西方统计学近两百年的发展历程,较之其他的西学知识在近代中国的传播和发展,统计学的历史则表现出了其自身的独特性,这种发展受到当时的社会政治、经济、文化等方面的影响甚大.这是由当时中国的社会背景以及统计学这门学科知识的特殊性质所决定的.     

What Curriculum for Mobility and Transport Studies? A Critical Exploration

To understand the complex meanings of mobility and to engage in transport planning and management processes, a variety of disciplines, skills, and tools are potentially useful. Universities have a limited amount of time and resources to train future professionals though. This poses a problem: where should the teaching priorities be? By means of a web-survey, this study has asked academics based at a number of universities what the disciplines, skills, and tools that — according to their personal viewpoints — are the most relevant for practitioners in the mobility and transport sector. The respondents generally support curricula that facilitate a holistic, non-specialised, understanding of mobility and transport issues.     

静力法与应力波法检测木结构工程材弹性模量的对比研究

通过采用静力法与应力波法检测同一批木材的弹性模量,对两者测试结果的差异原因进行了分析,并通过线性拟合发现2种方法的测试结果具有较好的相关性,在此基础上,提出了未来木结构工程材的无损检测研究发展趋势。     

青岛港(董家口港区)疏港铁路规划研究

研究目的:铁路作为港口的集疏运系统的重要组成部分,其布局与港口作业效率密切相关。鉴于董家口港区详规刚刚起步,为统筹优化港口布局规划,减少不必要的废弃工程,并为港口及临港工业区发展留有余地,特开展了青岛港(董家口港区)疏港铁路规划研究。研究结论:董家口港区内部可考虑设置港湾站、港前站、物流中心站,其中港湾站至港前站是疏港的主要通路。外部通路可选择青连铁路、山西中南部铁路。由于这两条铁路均为拟建项目,外部集疏运通路选择与两条线建设时机密切相关。若两线同时建设,可考虑首选青连铁路,再视港口和临港产业区发展情况,适时考虑与山西中南部铁路联通。