排序方式: 共有43条查询结果,搜索用时 15 毫秒
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介绍了国内外对水泥混凝土路面防治的各种方法,比较了各方法的优缺点,给出了弥补不足之处的方法。通过对广东S116线天目湖至北村的路况和承载能力的调查,及路面病害的成因分析,以路面力学性能为基础,探索新工艺和新材料在路面中的使用性能,并与传统的维修方法进行经济性等方面的比较。 相似文献
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通过对广清高速公路大燕河特大桥岩溶区桩基施工,总结了大型岩溶区的桩基施工技术及注意要点,可供类似工程参考。 相似文献
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Ronghui Liu Tony May Simon Shepherd 《Transportation Research Part A: Policy and Practice》2011,45(9):951-965
Macroscopic fundamental diagrams (MFD) of traffic for some networks have been shown to have similar shape to those for single links. They have erroneously been used to help estimate the level of travel in congested networks. We argue that supply curves, which track vehicles in their passage through congested networks, are needed for this purpose, and that they differ from the performance curves generated from MFD. We use a microsimulation model, DRACULA and two networks, one synthesizing the network for Cambridge, England, and one of the city of York, England, to explore the nature of performance curves and supply curves under differing patterns of demand.We show that supply curves differ from performance curves once the onset of congestion is reached, and that the incorrect use of performance curves to estimate demand can thus seriously underestimate traffic levels, the costs of congestion, and the value of congestion relief measures. We also show that network aggregated supply curves are sensitive to the temporal distribution of demand and, potentially, to the spatial distribution of demand. The shape of the supply curve also differs between origin–destination movements within a given network.We argue that supply curves for higher levels of demand cannot be observed in normal traffic conditions, and specify ways in which they can be determined from microsimulation and, potentially, by extrapolating observed data. We discuss the implications of these findings for conventional modelling of network management policies, and for these policies themselves. 相似文献
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宫内及哺乳期铅接触对子鼠学习记忆行为和海马神经元凋亡的影响 总被引:5,自引:0,他引:5
目的 探讨宫内和哺乳期铅接触子鼠学习记忆行为改变和海马结构神经元凋亡发生状况。方法 SD大鼠采用饮水加醋酸铅 2 0、2 0 0、2 0 0 0mg·L- 1 方法染毒 ,6周后交配 ,自然分娩 ,于子鼠断乳时停止铅接触 ,用暗室电击试验测试子鼠学习记忆行为改变 ;用原子吸收分光光度法测定血铅和脑铅含量 ;用HE染色和原位末端标记TUNEL法观察海马神经元细胞凋亡状况。结果 3个染铅组子鼠学习记忆能力均比对照组明显下降 ,血铅和脑铅含量均明显高于对照组 ,差异有显著性 (P <0 .0 5 ) ;TUNEL染色结果显示 :中、高铅组子鼠海马CA1、CA3、齿状回 (DG)区神经元细胞凋亡指数均明显高于对照组 ,差异有显著性 (P <0 .0 5 )。结论 宫内和哺乳期铅接触可损害子鼠的学习记忆行为 ,其机制可能与铅导致海马神经元细胞凋亡有关。 相似文献
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宫内及哺乳期铅接触子鼠海马神经元凋亡及bcl-2、bax基因的表达 总被引:4,自引:1,他引:4
目的 探讨宫内及哺乳期铅接触对子鼠海马神经元凋亡的诱发作用及对bcl 2、bax基因表达的影响。方法 SD大鼠采用饮水加 2 0 0 0mg·L-1醋酸铅染毒 6周后 ,雌雄按 2∶1合笼 ,自然分娩 ,于子鼠断乳时停止染毒 ,用原位末端标记TUNEL法检测海马神经元的凋亡状况 ;用SP免疫组化法观察凋亡调控基因bcl 2、bax表达。结果 TUNEL法染色结果显示 :染铅组子鼠海马CA1、CA3、齿状回 (DG)区神经元细胞凋亡指数均明显高于对照组 ,差异有显著性 (P <0 .0 1) ;SP免疫组化结果显示 :染铅组子鼠海马CA1、CA3、DG区bcl 2阳性细胞数表达较对照组减少 ,而bax阳性细胞数表达较对照组增多。结论 宫内和哺乳期铅接触可导致子鼠海马神经元凋亡 ,其机制可能与海马bcl 2蛋白表达下降、bax蛋白表达升高有关 相似文献
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