描述有效的原料药

尽管癌症治疗在过去的十多年取得了显著进展，但肿瘤学仍属于目前最不能满足临床需要的学科领域。在过去十多年里，临床药理学的进步和研发活动方面的巨大投资使得“癌症治疗”发展为“治疗过程研究”的数量急剧增加。但事实上，癌症和其他慢性疾病一样，治疗效果都很差，由此很多大型医药公司和生物制药公司都比以往更大力度的投入资金，用于肿瘤学和其他强效候选药物的研发上。[第一段]     

A path-based flow formulation for the traffic assignment problem

In order to improve cooperation between traffic management and travelers, traffic assignment is the key component to achieve the objectives of both traffic management and route choice decisions for travelers. Traffic assignment can be classified into two models based on the behavioral assumptions governing route choices: User Equilibrium (UE) and System Optimum (SO) traffic assignment. According to UE and SO traffic assignment, travelers usually compete to choose the least cost routes to minimize their own travel costs, while SO traffic assignment requires travelers to work cooperatively to minimize overall cost in the road network. Thus, the paradox of benefits between UE and SO indicates that both are not practical. Thus, a solution technique needs to be proposed to balance UE and SO models, which can compromise both sides and give more feasible traffic assignments. In this paper, Stackelberg game theory is introduced to the traffic assignment problem, which can achieve the trade-off process between traffic management and travelers. Since traditional traffic assignments have low convergence rates, the gradient projection algorithm is proposed to improve efficiency.     

The economic use of subsidies for urban mass transportation

The energy crisis and various urban problems stemming from auto congestion, pollution, and the cost of providing public highways have created enormous interest in revitalizing our urban mass transit systems. Currently much is being said and written regarding the efficacy of granting federal, state and/or local operating subsidies. In this article, the author reviews the transit industry's peak capacity problem, and questions the economic wisdom of providing operating subsidies, as some are now being provided, and how most will probably be administered in the near future. An alternative plan suggests the manner in which subsidies can eventually help the transit industry. The article concludes with an analysis of what research efforts are needed in many urban transit systems and how subsidies can be used to support such research.     

Airport ground transportation management: moving towards the turn of the century

Over the last fifty years ground transportation management (GTM) has slowly evolved into a major function at most larger airports. However, during this time there has been relatively little written discussing the idea, organization structures or duties included within this functional activity. This paper reviews and updates the limited, earlier research. This study replicates initial work done in 1989 and thus provides a short longitudinal view of the airport GTM function. The final results demonstrate the current position of GTM and suggest trends for the future.     

浅谈空气悬架

1空气悬架发展的简史 空气弹簧发明于100年前，它的雏形是马车上使用的皮囊。直到20世纪30年代出现的纤维叠层橡胶制作技术才使制造实用的空气弹簧成为可能。人们首先考虑在客车上应用空气弹簧。     

An econometric approach to the planning of road development in developing countries

The tools and techniques of econometrics are conventionally used in the estimation and testing of relationships between different economic variables, and their application features in the literature of transport economics.

This paper seeks to make use of econometrics in a wider field to solve a number of economic problems that crop up in investment decisions on road development in developing countries.

This study is divided into four sections with a brief conclusion. Section 1 deals with the problems that should be taken into account when taking investment decisions on road systems. In Section 2, an attempt is made to show how econometric tools can be applied in sorting out those problems. Section 3 highlights the limitations of the approach, and in Section 4, a case study is undertaken to verify the applicability of the model in reality.     

Vulnerability of Caribbean Island Cemeteries to Sea Level Rise and Storm Surge

The Intergovernmental Panel on Climate Change reports that rising seas by the end of this century will increase the severity of coastal flooding and erosion. The Caribbean region is home to many small islands that are vulnerable to sea level rise and storm surge. Much of the literature examining impacts of sea level rise in the Caribbean focuses on ecosystems, infrastructure, and recreation. Few studies have examined how sea level rise will impact historic and culturally important places. In an effort to address this research gap, geographic information systems and crowd-sourced, georeferenced photographs were used to build a first-of-its-kind database of 542 Caribbean small island cemeteries. Vulnerable cemeteries were then identified based upon elevation, proximity to the ocean, and the coastal profile. Over one-fifth of the cemeteries surveyed are within 100 m of the coast. The highest concentrations of vulnerable cemeteries are on flat islands such as the Cayman Islands. Yet, some mountainous islands such as Saint Martin also have potentially vulnerable cemeteries. These findings suggest that the bereaved, cemetery managers, and managers of coastal areas that have cemeteries may have additional considerations when making long-term decisions about where and how to bury the deceased.     

Analysis and Potential Alternatives for the Disputed South China Sea from Ocean Governance in the Polar Regions

Sovereignty claims over insular features and maritime jurisdiction in the South China Sea have been disputed for decades, and a governance regime to address ocean-related issues is urgently needed. This article first introduces the notion of a regime, and examines details of cooperation mechanisms in the Polar Regions. Lessons that can be applied to the South China Sea include that both soft and hard law regimes work to bring States concerned together to cooperate on the “commons” issues even when military conflicts or sovereignty disputes still exist. Consensus among bordering States would be necessary to make the South China Sea a “zone of peace.” Mechanisms that accommodate the various sovereignty claims and freeze existing and new claims to, as well as to prohibit military activities in, the South China Sea are recommended. Lastly, if a cooperative mechanism were to be established in the future, the Arctic regime would be more applicable to the South China Sea than the Antarctic regime due to their geographic nature. Thus, only States bordering the South China Sea should have voting and decision-making rights in the cooperative mechanism. As always, the political will of all parties is paramount to the success of such an endeavor.     

Disturbance compensation with a torque controllable steering system

Via a conventional steering system the driver perceives desired and disturbing effects such as road feedback and resonance effects, respectively. They appear with overlapping frequency spectra within the driver's steering torque. This paper introduces a control algorithm that is suppressing periodic disturbances without affecting useful steering road feedback attributes as well as regular power assistance characteristic. This is realised by an integrated torque actuator within the steering column in conjunction with a conventional Hydraulic-assisted Power Steering (HPS) system.     

From suspended particles to strata: The fate of terrestrial substances in the Gaoping (Kaoping) submarine canyon

The river–sea system consisting of the Gaoping (new spelling according to the latest government's directive, formerly spelled Kaoping) River (KPR), shelf, and Submarine Canyon (KPRSC) located off southern Taiwan is an ideal natural laboratory to study the source, pathway, transport, and fate of terrestrial substances. In 2004 during the flood season of the KPR, a system-wide comprehensive field experiment was conducted to investigate particle dynamics from a source-to-sink perspective in the KPRSC with the emphasis on the effect of particle size on the transport, settling, and sedimentation along the pathway. This paper reports the findings from (1) two sediment trap moorings each configured with a Technicap PPS 3/3 sediment trap, and an acoustic current meter (Aquadopp); (2) concurrent hydrographic profiling and water sampling was conducted over 8 h next to the sediment trap moorings; and (3) box-coring in the head region of the submarine canyon near the mooring sites. Particle samples from sediment traps were analyzed for mass fluxes, grain-size composition, total organic carbon (TOC) and nitrogen (TN), organic matter (OM), carbonate, biogenic opal, polycyclic aromatic hydrocarbon (PAH), lithogenic silica and aluminum, and foraminiferal abundance. Samples from box cores were analyzed for grain-size distribution, TOC, particulate organic matter (POM), carbonate, biogenic opal, water content, and ²¹⁰Pb_ex. Water samples were filtered through 500, 250, 63, 10 µm sieves and 0.4 µm filter for the suspended sediment concentration of different size-classes.Results show that the river and shelf do not supply all the suspended particles near the canyon floor. The estimated mass flux near the canyon floor exceeds 800 g/m²/day, whose values are 2–7 times higher than those at the upper rim of the canyon. Most of the suspended particles in the canyon are fine-grained (finer than medium silt) lithogenic sediments whose percentages are 90.2% at the upper rim and 93.6% in the deeper part of the canyon.As suspended particles settle through the canyon, their size-composition shows a downward fining trend. The average percentage of clay-to-fine-silt particles (0.4–10 µm) in the water samples increases from 22.7% above the upper rim of the canyon to 56.0% near the bottom of the canyon. Conversely, the average percentage of the sand-sized (> 63 µm) suspended particles decreases downward from 32.0% above the canyon to 12.0% in the deeper part of the canyon. Correspondingly, the substrate of the canyon is composed largely of hemipelagic lithogenic mud. Parallel to this downward fining trend is the downward decrease of concentrations of suspended nonlithogenic substances such as TOC and PAH, despite of their affinity to fine-grained particles.On the surface of the canyon, down-core variables (grain size, ²¹⁰Pb_ex activity, TOC, water content) near the head region of the canyon show post-depositional disturbances such as hyperpycnite and turbiditic deposits. These deposits point to the occurrences of erosion and deposition related to high-density flows such as turbidity currents, which might be an important process in submarine canyon sedimentation.