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Fungal infection remains a major problem worldwide, yet treatment options are limited owing to the lack of effective drugs, the significant toxicity of available compounds, and the emergence of drug resistance. The low toxicity of calcofluor white （CFW） is an attractive antifungal compound for its known inhibitive effects on trichophyton rubrum and candida albicans growth. However, the efficacy of CFW is limited in most cases. In order to search for effective means to improve its efficacy, using saccharomyces cerevisiae as a model, we have used microarrays to examine the cell＇s response when treated with CFW on the genome scale. We found that both the PKC-SLT2 （i.e, protein kinase C-mitogen activated protein kinase） and the glycogen metabolic pathways are activated upon CFW treatment. These results suggest that the key components in these pathways could be targeted by other drugs to counter the cell＇s compensative response, thus to further substantiate the inhibitive effect of CFW on fungal growth, which may lead to treatment regimens with improved efficacy of this compound in clinical applications. 相似文献
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目的应用三维有限元分析不同材料嵌体修复邻牙合(Ⅱ类)洞型后牙体组织的应力变化趋势。方法采用锥形束CT(CBCT)扫描的方法,应用Mimics、Geomagic逆向工程等软件建立含嵌体修复的邻牙合面(Ⅱ类)洞型三维有限元模型,并求解分析各模型中垂直、侧向力(舌向45°)加载条件下牙体主应力峰值及不同嵌体修复邻牙合(Ⅱ类)洞后牙体的Von-mises应力分布状况。结果建立了包含牙釉质、本质、髓腔以及牙周膜、牙槽骨的精细下颌第一磨牙邻牙合面(Ⅱ类)近中-牙合(MO)洞型不同嵌体修复三维有限元模型。侧向加载(舌向45°)时牙体的应力峰值明显高于垂直加载,2种加载下4种材料应力值按照降序排列为:钴铬合金>金合金>瓷>树脂。4种不同材料对牙体组织的应力分布相似,牙体的应力峰值主要在洞底部牙本质所对应的髓腔处。结论在下颌第一磨牙邻牙合面(Ⅱ类)洞型的嵌体修复中,与其他3种材料相比,树脂嵌体因其与牙体组织更加相近的弹性模量而产生对牙体组织更小的应力,有利于减少牙折等危险。 相似文献
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本文通过对应用电子技术专业的研究、探索和实践,总结出“2＋1工学结合”的高职教育模式。此模式对三年制的高等职业教育分为二个教学阶段。第一个阶段是学生在校进行必要的理论学习和专业技能训练,第二个阶段是到企业进行一年的顶岗实习。有“三个观念”要改变：一是教师的传统教学思想和教学方法要改变;二是传统的培养目标和教学计划要改变;三是学生理想的就业观念要改变。 相似文献
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本文通过计算分析影响39 000 DWT化学品/成品油船轴系扭振的各种因素,发现调整轴径可以改善轴系扭振和校中状况,并且能够降低轴系材料和制造成本,实现轴系扭振优化设计。 相似文献
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