强化胎盘因子对细胞因子产生的影响

在观察了强化胎盘因子对淋巴细胞增殖试验影响的基础上,应用CTLL-2和7TD_1两种细胞株对强化胎盘因子刺激后的小鼠脾脏细胞分泌白细胞介素-2(IL-2)和白细胞介素-6(IL-6)水平分别进行了实验研究。结果表明,强化胎盘因子促进T淋巴细胞增殖,使小鼠脾脏细胞分泌IL-2和IL-6水牛均明显提高,有增强机体免疫功能的作用。     

IPv4与IPv6的比较研究

文章主要描述了IPv4协议与 IPv6协议的不同之处,分别从首部格式、地址空间、地址分配、路由协议、域名解析、自动配置、安全性等方面对IPv6与IPv4进行了比较研究。指出了IPv6有别于IPv4的新的重要特征。     

中间轴驱动装置固定对弹性悬挂式机车动力学性能的影响

为防止弹性悬挂式机车中间轴驱动装置横向位移过大,发生碰撞,提出了端轴驱动装置弹性悬挂、中间轴驱动装置固定连接的方式。利用多体动力学软件SIMPACK建立整车动力学模型,对比分析驱动装置悬挂方式对机车动力学性能的影响,认为采用这种悬挂方式是合理可行的。     

信号安全技术在DS6-60计算机联锁系统中的主要应用

计算机联锁系统因其应用领域的特殊性,在满足铁路运营需求的同时,必须保证铁路运输的安全。因此对计算机联锁系统的安全性有较严格的要求。广义的信号安全技术包含故障-安全技术、可靠性和易维护性等方面。DS6-60型计算机联锁系统是基于故障-安全技术研发的通过欧标认证的铁路信号安全控制系统。阐述了DS6-60型计算机联锁系统各个环节的主要安全技术应用。     

基于随机Petri网的GSM-R双层网络建模与性能分析

利用随机Petri网,综合信道降质、链路中断、越区切换、灾害等因素,建立GSM-R的同站址网络与交织站址网络的故障模型,针对同站址与交织站址两种不同的网络结构,给出利用马尔可夫链求解可靠性与可用性的方法。通过马尔可夫链的有关概率分别计算:不同网络结构的可靠性;不同列车运行速度对应不同网络结构的可用性。分析计算结果表明:同站址网络的可靠性与可用性远高于交织站址网络,主要原因是同站址网络中一层基站业务中断时不会导致系统失效,交织站址网络中一层基站业务中断时,并联的另一层相邻两个基站均可以提供业务才不会导致系统失效。另外,同站址网络中越区切换速率较小,有效减小了列车越区切换对可靠性与可用性的影响。     

Full six degrees of freedom coupled dynamic simulation of ship collision and grounding accidents

By taking advantage of the user-defined load subroutine (loadud) and the user common subroutine (usercomm) in LS-DYNA, the authors proposed a new coupled approach for simultaneously calculating structural damage and the planar 3DOF ship motions in ship collisions. The coupled procedure aimed at predicting the detailed structural damage together with reasonable global ship motions. This paper extends the method to consider the full 6DOF ship motions; thus, ship collision as well as grounding accidents can be properly handled. This method is particularly useful for design purposes because the detailed ship hull profile is not needed.A traditional ship maneuvering model is used for the in-plane surge, sway and yaw degrees of freedom with a series of nondimensional coefficients determined from experiments. It is assumed that the out-of-plane degrees of freedom are not coupled with the in-plane ship motions, and there is no coupling among roll, pitch and heave motions. The implementation is verified through free decay tests, and the obtained natural periods show good agreement with theoretical results.Several collision and grounding cases are simulated in which a supply vessel crashes into rigid plates with different orientations. The effects of the roll motion, the heave and pitch motions and the full 6DOF motions are studied. The results are compared with those from a 6DOF decoupled method. Ship motions through the proposed method compare reasonably well with SIMO results. It is found that several consecutive impacts may occur in the simulation of one collision case due to the periodic motions. This is not taken into account in the decoupled method, which makes this method unconservative.     

The changes of neuronal activity of the zone incerta in a rodent model of Parkinson＇s disease

Objective To study the changes in neuronal activity of the zone incerta (ZI) following the unilateral lesion of the nigrostriatal pathway. Methods Eiectrophysiological recordings of ZI neurons were made in normal rats and in two groups of rats at different time intervals after injection of 6-hydrodopamine (6-OHDA) into the pars compacta of snbstantia nigra by extracellular recording in vivo. Results The results showed a significant increase in the mean firing rate of ZI during the second and fourth weeks after 6-OHDA lesion [-n=32, (3.6±2. 2)Hz, P<0.001; n=35, (9.3±6.6)Hz, P<0. 001, respectively] compared to that of normal rats [n=39, (9.2±5.2)Hz]. However, no significant change was observed between two groups of 6-OHDA-lesioned rats. With regard to firing pattern, 7.7%(3/39) of ZI neurons discharged regularly, 82.1% (32/39) irregularly and 10. 3% (4/39) in bursts in normal rats. During the second week after 6-OHDA lesion, the regular, irregular and bursting firing neurons recorded in the ZI were 9.4% (3/32), 59. 4% (19/32) and 31.3% (10/32), and during fourth week, the regular, irregular and bursting firing neurons were 14.3% (5/35), 57.1% (20/35) and 28. 6% (10/35), respectively. The firing pattern of the neurons in the three different groups did not change significantly. Conclusion These results suggest that the firing rate of ZI neurons in 6-OHDA-lesioned rats is increased significantly, which may contribute to the pathophysiology of Parkinson's disease.     

弥漫性轴索损伤后CD4~+/CD8~+ T细胞比值、IL-6、IL-10水平变化及预后相关危险因素的Logistic回归分析

目的研究弥漫性轴索损伤(DAI)后患者外周血CD4+/CD8+T细胞比值及炎症因子IL-6、IL-10水平的变化,探讨影响DAI患者预后的相关危险因素及可能的预测因子。方法收集115例DAI患者的相关临床资料及伤后至少6个月的随访结果,并将采集的患者外周血采用流式细胞仪检测CD4+、CD8+T细胞及其比值,ELISA法检测IL-6、IL-10水平,对免疫炎症指标及临床资料进行单因素和多因素分析,多因素分析采用Logistic回归分析。结果DAI后合并其他脑损伤、瞳孔改变、伤后昏迷时间及入院时GCS评分是影响患者预后的危险因素,而其他因素则与预后不相关。CD4+/CD8+T淋巴细胞比值降低是DAI后发生ARDS/ALI的危险因素,CD4+/CD8+T淋巴细胞比值与患者预后关系不大,而ARDS/ALI的发生则是影响DAI患者预后的重要危险因素。IL-6增加与DAI后ARDS/ALI密切相关,可作为ARDS/ALI发生的预测因子,其水平是患者预后的危险因素,而IL-10则在此过程中与ARDS/ALI不相关,且与患者预后无关。结论 CD4+/CD8+T淋巴细胞比值降低是DAI后发生ARDS/ALI的危险因素,IL-6可作为ARDS/ALI发生的预测因子。DAI后与患者预后相关的危险因素包括合并其他脑损伤、瞳孔改变、伤后昏迷时间、入院时GCS评分、IL-6水平及并发ARDS/ALI。     

基于数值模拟的钛合金锯齿状切屑研究

切削加工中切屑成形是一种典型的大变形问题,它涉及到材料非线性、几何非线性以及边界非线性等问题。本文利用DEFORM-2D对钛合金(Ti6Al4V)进行了锯齿状切屑形成过程的有限元模拟,分析了切削过程中的应力场、应变场及温度场,探讨了锯齿状切屑的形成机理,获得了切削参数对锯齿状切屑形态的影响规律,为优化切削参数、提高刀具寿命提供了参考。     

交织区长度对车道变换频率的影响

交织区长度是影响交织区运行特性的重要参数,影响着交织车辆进行车道变换的紊动程度。找出了车道变换频率与其相应产生的车道变换长度的一一对应关系,定义了车道变换长度随机变量,通过分析给定交织区车道变换长度的统计分布来反映交织操作车道变换的频度。在其他因素不变的条件下,运用动力学理论、概率论等方法定量分析了交织区长度对车道变换产生的影响。