神经内科医护人员手卫生依从性对静脉留置针感染的影响

目的:探讨神经内科医护人员手卫生依从性对静脉留置针感染的影响。方法:将62名医护人员分为手卫生习惯良好组34名和手卫生习惯欠佳组28名,收集神经内科行静脉留置针的患者583例,手卫生习惯良好组对305例患者进行静脉留置针操作,手卫生习惯欠佳组对278例患者进行静脉留置针操作。比较两组感染发生情况。结果:具有良好手卫生习惯的医护人员进行静脉留置针操作时可显著降低静脉留置针感染的发生率(P<0.05)。结论:加强医护人员手卫生监督是降低静脉留置针感染的重要措施,应加强手卫生的宣传普及工作。     

兔眼环孢霉素A缓释微球的眼内释药性研究

目的建立兔眼房水中环孢霉素A缓释微球的高效液相测定方法,考察在不同给药剂量下兔眼房水中的药物代谢特性,为该药预防后发性白内障提供理论依据。方法兔眼行晶体囊外摘除,左眼前房及囊袋内注射环孢素微球,右眼给予空白微球作对照,采用高效液相色谱法监测给药后4周内兔眼房水中环孢霉素A的浓度。色谱柱为反相C18硅胶柱,柱温为60℃,流动相为乙腈-水(67∶33),检测波长210nm。结果兔眼房水中环孢霉素A的浓度在0.13-1.25mg/L范围内呈良好线性关系(r=0.9951),最低检测浓度0.13mg/L,回收率95.91%,日间和日内精密度均小于5.0%。缓释微球的释药速率适中,兔眼前房给药后可在2周内维持较高浓度,高低两种给药剂量下,环孢霉素A的吸收半衰期(t1/2Ka)和血浆清除速率(CL)经检验无统计学差异,药时曲线下面积(AUC)和峰浓度(Cmax)与剂量之间线性相关。结论环孢素A缓释微球在兔眼内有较高的生物利用度,实验期内可达到抑制后发性白内障的有效浓度。     

人工插药爆破处理软基在连云港庙岭三期试验围堤中的应用

连云港庙岭三期试验围堤工程采用人工插药爆破处理软基,工程效果良好,并节省工程爆破费用35％,收到了良好的经济效益。     

PEKING UNIVERSITY

Type of Company： Government institution. New Preparartions and Late-Model Drug Delivery System Technical Plaform of Peking University School of Pharmaceutical Sciences is a national technical plaform for developing new and important drugs. The person in charge for the platform is a pharmaceutical science professor of Peking University School of Pharmaceutical Sciences. The plaform selects the following as the main research areas： late-model carrier drug delivery system, biotechnological drug delivery system,     

Quantitative analysis of a novel antimicrobial peptide in rat plasma by ultra performance liquid chromatography-tandem mass spectrometry

We described the first results of a quantitative ultra performance liquid chromatographytandem mass spectrometry method for a novel antimicrobial peptide （phylloseptin, PSN-1）. Chromatographic separation was accomplished on a Waters bridged ethyl hybrid （BEH） C18 （50mm× 2.1 mm, 1.7 μm） column with acetonitrile-water （25：75, v/v） as isocratic mobile phase. Mass spectrometry detection was performed in the positive electrospray ionization mode and by monitoring of the transitions at m/z 679.6/120, 509.6/120 （PSN-1） and m/z 340.7/165 （Thymopentin, IS）. Protein precipitation was investigated and the recovery was satisfactory （above 82%）. The method was shown to be reproducible and reliable with intra-day precision below 5.3%, inter-day precision below 14.2%, and linear range from 0.02 to 2 lag/mL with r〉0.994. The method was successfully applied to a pharmacokinetic study of PSN-1 in rats after intravenous administration.     

Determination of metronidazole in a rat stomach by HPLC for obtaining basic data of the eradication therapy of Helicobacter pylori

In the eradication therapy of Helicobacter pylori changes of antibiotics as these concentrations or amount in the stomach after oral administration were not clear. A simple and accurate method for dete...     

Postdoctoral Fellow Position Is Immediately Available at Tsinghua University

The successful candidate will focus research efforts on the research and application of nano drug delivery system. The position requires a PhD degree with a strong background in pharmacy or molecular pharmacology. Highly motivated individuals with excelle