Screening of chemokine receptor CCR4 antagonists by capillary zone electrophoresis

Abstract CC chemokine receptor 4 （CCR4） is a kind of G-protein-coupled receptor, which plays a pivotal role in allergic inflammation. The interaction between 2-（2-（4-chloro-phenyl）-5-{[（naphthalen-1- y...     

Comparative assessment of liquid sloshing in dry and wet storage tank of floating offshore platform

In order to explore the characteristics of the single-layer liquid sloshing in offshore dry oil storage tank and the two-layer liquid sloshing in offshore wet oil storage tank, two series of experiments were carried out: one was free surface sloshing in a closed rectangular tank partially filled with colored water, and the other was interfacial sloshing in the identical tank but completely filled with white oil and colored water. The tank was mounted on a shake table and was subjected to harmonic horizontal excitation with different excitation amplitudes and a wide range of excitation frequencies, including the first seven natural modes of single-layer or two-layer liquid system. The present study find that the frequency responses of interfacial sloshing wave are analogous to those of the free surface sloshing wave, but smaller in amplitudes. The experiments also produce results that are unique to the two-layer liquid sloshing. For example, when the external excitation frequency is equal to or close to the odd mode natural frequency of two-layer liquid system, a complicated three-dimensional (3D) gravity-capillary wave might be generated at the oil-water interface. Finally, the comparisons of free surface and interfacial sloshing in the viscous damping ratio, higher sloshing modes, impact pressure amplitude and mass center displacement were conducted, which revealed the superiority of wet storage technology in structural safety and dynamic stability.