胶体~(32)磷瘤内注射治疗肝癌的动物实验与临床应用研究

将Walker－256瘤株接种于大鼠肝脏内制成肿瘤动物模型。于肿瘤中心注射胶体32磷，注射后1h，3、7、14、30d放射性瘤肝比值分别为，56．75、6、16、2．50、1．83和1．43。血、心、肺、肾、脾、骨等组织内的放射量在0．061％以下。第7天时谷雨转氨酶有一过性增高外其他肝功指标、肾功、血常规均无显著变化。治疗后肿瘤体积较前缩小，且随时间推移，肿瘤生长率逐渐降低。同时，对10例原发性肝癌患者进行了胶体32P内照射治疗，均无相关并发症发生，其中1例患者治疗后肿块明显缩小，并于30d后行二期切除。故认为胶体32磷瘤内注射治疗肝癌是一种安全可行的有效方法，值得进一步探讨。     

Investigation of tailpipe and evaporative emissions from China IV and Tier 2 passenger vehicles with different gasolines

The limited understanding of vehicular emissions in China, especially evaporative emissions, is one obstacle to establishing tighter standards. To evaluate tailpipe and evaporative emissions, two typical China IV vehicles and one Tier 2 vehicle with an onboard refuelling vapour recovery (ORVR) system were selected and tested. One of the China IV vehicles was fuelled with gasoline, E10 and M15, respectively, to investigate the effect of fuel properties on vehicular emissions. For each vehicle, cold-start tailpipe emission tests were conducted first, followed by an evaporation test. Based on the emission factors and real-world vehicle activity data, the annual tailpipe and evaporative hydrocarbon (HC) emissions of each vehicle were calculated and compared. The results show that E10 and M15 significantly reduced the tailpipe CO and particle number (PN) emissions but seriously aggravated the NOx emissions, especially for M15. The hot soak losses (HSLs) and diurnal breathing losses (DBLs) were slightly impacted by the fuel properties. The annual evaporative emissions with E10 and M15 were higher than that with gasoline. The ORVR system effectively controlled the evaporative emissions, especially for DBLs. Evaporative emissions from the China IV vehicles were 1.1–1.4 times the tailpipe HC emissions. Additionally, the evaporative emission factors of the China IV vehicles were almost 50% lower than the standard (2.0 g/test), whereas their annual evaporative emissions were almost 1.8–2.8 times higher than those from the Tier 2 vehicle. Therefore, controlling evaporative emissions currently remains a great need in China, and the ORVR might be a recommended evaporative control technology.     

姜黄素促进RAW264.7源性M1巨噬细胞向替代激活M2表型极化

目的观察姜黄素对LPS和IFNγ诱导的RAW264.7巨噬细胞(M1)极化的影响及机制。方法不同浓度姜黄素(6.25、12.5、25μmol/L)干预LPS和IFNγ诱导的RAW264.7巨噬细胞(M1)12h,同时再加入20μmol/L GW9662与25μmol/L姜黄素共同干预LPS和IFNγ诱导的RAW264.7巨噬细胞(M1)12h,采用Real-time PCR、ELISA及Western blot方法检测IL-1β、IL-6和M2表型标志分子KLF4、FIZZ1、MGL1、PPARγ的表达,及阻断PPARγ后KLF4和FIZZ1的表达。结果不同浓度姜黄素均能上调LPS和IFNγ诱导的RAW264.7巨噬细胞(M1)的M2标志分子的表达,并且抑制炎症因子IL-1β和IL-6的分泌;阻断PPARγ后,RAW264.7巨噬细胞源性M1表型巨噬细胞表达M2标志分子下调。结论姜黄素通过活化PPARγ促进LPS和IFNγ诱导的RAW264.7巨噬细胞(M1)向M2表型极化。     

京津客运专线预制箱梁架设施工技术

结合国内首条客运专线——京津城际轨道交通工程中32m简支箱梁的架设要求及运架作业情况,详细介绍了架设900t/32m箱梁的工艺流程及运输、吊装和架设的关键施工技术,对同类工程施工有借鉴意义。     

基于RA8876M的船舶机舱一体化显控模块设计

针对船舶机舱内设备的便捷操作需求,采用STM32F429芯片和RA8876M显示控制器,研究设计一套适于船舶机舱使用的具有接口丰富、操控便捷和应用场景丰富等优点的一体化显控模块。RA8876M显示控制器能在无操作系统环境下正常工作,有助于降低模块整体应用程序的开发难度;利用RA8876M显示控制器配套上位机软件可视化编程的优势,能大幅缩短软件开发周期。通过在某船舶机舱延伸报警系统中应用,验证该一体化显控模块具有优良的工作性能。     

The Bid-rent Land Use Model of the simple,efficient, elegant,and effective model of land use and transportation

Integrated land use/transportation forecasting models add significant policy and infrastructure alternatives analysis capabilities to the urban planning process. The financial, time, and staff requirements to develop these models has put them beyond the reach of most small to medium sized urban areas. This paper presents the land use allocation submodel of the Simple, Efficient, Elegant, and Effective model of land use and transportation (SE³M), an integrated land use and transportation forecasting model founded upon Economic Base Theory and Bid-rent Theory. The Bid-rent Land Use Model (BLUM) is an agent based, spatial competition model utilizing unique utility curves for willingness to pay and incomes for budget constrained abilities to pay for each agent. The model structure, estimation, calibration, implementation, and validation are presented. With a single year of land use data available, the validation approach used the Kappa Index of Agreement to spatially check model outputs against base year control data while controlling for agreement by chance. The U.S. territory of Guam is used as the case study/proof of concept implementation for this model framework. Once calibrated, BLUM could solve the spatial competition problem on Guam in less than two minutes of processing time with over 90% accuracy.     

汽油机电控单元的电磁兼容性设计

介绍了设计研制以摩托罗拉 6 8K系列芯片为控制单元的 32位电控单元 ,为今后控制功能的完善和控制性能的提高搭建了硬件平台。设计过程中引入了电磁兼容性 (EMC)的设计 ,采用了包括元器件布局原则和布线策略设计、地线设计、屏蔽和隔离、去耦及滤波等许多技术措施来提高系统的电磁兼容性 ,优化电控单元的设计。     

自卸式远洋散装水泥运输船特殊结构强度分析研究

以远洋散装水泥运输船为研究对象,采用三维有限元分析方法及ＤＮＶ船级社的ＳＥＳＡＭ结构计算软件,从船体结构强度、船舶振动预报和船体结构温度应力等方面对该型船结构设计的多项技术难点进行了详细的计算和评估。并且着重对大型散装水泥运输船间断内底板、中纵舱壁以及高腹板旁桁材等特殊结构的受力状态及应力分布进行分析和探讨。为自卸式散装水泥运输船的结构优化设计提供技术支撑。     

4MlE在施工项目管理中的拓展

通过对施工项目管理中"4M1E"的分析及其在当今项目管理中的拓展,为企业进行其项目管理提供理论依据.     

紧急疏散情况下地铁车站动态瓶颈识别

随着城市轨道交通系统逐渐成网,地铁车站日渐拥挤,为了制定科学有效的紧急疏散方案,有必要预先找到车站瓶颈点。基于时间可靠度函数模拟乘客在紧急情况下路径选择行为,在此基础上引入M//G/C/C排队模型对车站排队系统各个服务台进行排队性能指标计算,找出潜在瓶颈点。以广州地铁3号线岗顶站为例,结合车站硬件设施尺寸数量,模拟计算最恶劣情况下乘客疏散过程,找到3处潜在瓶颈点,测算结果与实际观测情况相符合,验证了该方法的有效性。