Engineering Terpenoid Indole Alkaloids Biosynthetic Pathway in Catharanthus roseus Hairy Root Cultures by Overexpressing the Geraniol 10-hydroxylase Gene

Secondary metabolites are low-molecularweight compounds produced widely within theplant kingdom. Plant alkaloids constitute thelargest group of natural products and indole alka-loids represent one of the most important groups ofplant-derived natural products. The terpenoid in-dole alkaloids (TIAs) are a large group of sec-ondary metabolites found in a limit number of plantspecies as periwinkle Catharanthus roseus. SeveralTIAs in C. roseus are exploited for their pharma-ceutical applications…     

ANALYSIS OF STRYCHNINE ALKALOIDS IN BIOLOGICAL SAMPLES BY THIN-LAYER CHROMATOGRAPHIC DENSITOMETRY AND DISTRIBUTION STUDY OF STRYCHNINE IN INTOXICATED RATS

Strychnine(STN),isolatedfromStrychnosNUX-VomicaL.,isamainactivecomponentofNUXVomicafi]ltpossessestypicalalkaloidcharacteristicsandusuallyco--existswiththesimilarstructuresubstancebrucine(BRN).Intoxicologicalanalysistheclassiccolourreactions,microcrystaltestsandbioassaymethodst2)havethedisadvangesoflowsensitivityandpoorselectivity.Recently,althoughseveralkindsofchromatographictechniquese.g.highperformaneliquidchromatography(HPLC)t')andthinlayerchromatography(TLC)")techniqueshavebeensug…     

Diterpenoid alkaloids from a Tibetan medicinal plant Aconitum richardsonianum var. pseudosessiliflorum and their cytotox

The chemical constituents from Aconitum richardsonianum var.pseudosessiliflorum were investigated.The roots of this plant were extracted three times with 90% EtOH at the room temperature.The ethanol extracts were combined and concentrated under reduced pr