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Objective To study the effects of MMP-9 (Matrix Metalloproteinase-9, MMP-9) in the pathogenesis of abdominal aortic aneurysms (AAAs) by localizing the expression of MMP-9 in the aneurysmal tissues. Methods By , the frozen sections (5μm) with aneurysmal tissues (n = 10) were incubated with MMP-9 antibody-added agents, then the sections were stained and observed under the microscope to localize the expression of MMP-9, which displayed a brown precipitate within the arterial walls. The normal arterial wall tissues(n= 10) and the diseased arterial wall tissues from the arterial occlusive diseases (AODs) (n= 15) were also immunized exactly the same way as control. Results A quantity of positive granules which appeared within the aortic media showed the strong expression of MMP-9 in the AAAs, with the positive rate reaching 95 % (19/20), while no expression of MMP- 9 was observed in the normal artery. However, the scattered distributed positive granules were seen within the arterial wall of some cases of the AOI)s, implying the weak positive expression of MMP-9 in this disease with the positive rate of 26.7% (4/15). There was a significant difference of the expression of MMP-9 within the arterial wall between the AAAs and AODs(P〈0.01 ). Conclusion High expression of MMP-9 within the aortic media faciliatates the degradation of collagen and elustin fibres and subsequent dilation of the aortic artery , thus playing an important role in the pathogenesis of AAAs. To refrain MMP-9 from enhanced expressing within the aortic wall is of clinical significance in the prevention and treatment of AAAs. 相似文献
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介绍国内丰田轿车发动机电动燃油泵的2种典型控制电路。对每种控制电路的工作原理、控制过程进行了详细说明,并给出了丰田威驰和锐志实车控制电路,为分析、排除不同丰田发动机电动燃油泵故障提供了依据。 相似文献
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通过根据ECM的传感器及信号输入及输出的逻辑关系,对一辆宝骏630手动档发动机换档过程转速异常升高的故障进行诊断和查找,最终找出导致故障的原因。 相似文献
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