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目的建立兔眼房水中环孢霉素A缓释微球的高效液相测定方法,考察在不同给药剂量下兔眼房水中的药物代谢特性,为该药预防后发性白内障提供理论依据。方法兔眼行晶体囊外摘除,左眼前房及囊袋内注射环孢素微球,右眼给予空白微球作对照,采用高效液相色谱法监测给药后4周内兔眼房水中环孢霉素A的浓度。色谱柱为反相C18硅胶柱,柱温为60℃,流动相为乙腈-水(67∶33),检测波长210nm。结果兔眼房水中环孢霉素A的浓度在0.13-1.25mg/L范围内呈良好线性关系(r=0.9951),最低检测浓度0.13mg/L,回收率95.91%,日间和日内精密度均小于5.0%。缓释微球的释药速率适中,兔眼前房给药后可在2周内维持较高浓度,高低两种给药剂量下,环孢霉素A的吸收半衰期(t1/2Ka)和血浆清除速率(CL)经检验无统计学差异,药时曲线下面积(AUC)和峰浓度(Cmax)与剂量之间线性相关。结论环孢素A缓释微球在兔眼内有较高的生物利用度,实验期内可达到抑制后发性白内障的有效浓度。 相似文献
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Gang?Liu Yukio?FujimotoEmail author Yoshikazu?Tanaka Eunsang?Im 《Journal of Marine Science and Technology》2004,9(2):63-69
A stress intensity factor (SIF) measurement method for cracks using a piezoelectric element and an electrostatic voltmeter is presented. In this method, an isotropic piezoelectric element is first attached near the tip of the crack. Then surface electrodes are attached to three different positions on the piezoelectric element. The electric potentials of the surface electrodes, which are proportional to the sum of the stress (
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) on the structural member, are measured by an electrostatic voltmeter during load cycling. The mode I and mode II SIFs of the crack are estimated using the relationship between the SIF and (
x
+
y
). The applicability of the proposed method is examined through experiments and numerical analysis. 相似文献
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静电陀螺监控器的基本数学模型 总被引:2,自引:0,他引:2
本文利用天文导航中的“双星定位”法和陀螺力学中的进动原理推导了六常平架式静电陀螺监控器的基本数学模型,并根据该系统的结构特点及工作原理给出了模型中的有关参数与可测信息之间的关系。 相似文献
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TBM法隧道施工技术在我国已经得以大力推广,同时施工的TBM数量已达40余台(套),有TBM施工业绩的企业近20家。TBM法隧道施工规模的扩大,并未能带动整体施工水平的全面提升,TBM掘进施工速度差异巨大且不均衡已经成为较为显著的问题,导致工期延迟、成本增加,造成巨大的经济和社会效益损失。结合近20年的TBM施工实践,探索并实施SPS作业法,即TBM持续、均衡、快速施工技术,提出“3个基础”“10项措施”实现适宜地质条件下TBM持续、均衡、快速施工;而在恶劣地质条件下,通过完善设备功能与性能、改进施工工艺,提升TBM工程适应性; 从而促进TBM工法科学、可持续发展。 相似文献
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Simple adaptive filtering scheme to improve measurement accuracy of gyroscope on angular motion base
The objective of this work is to improve the measurement accuracy of a gyroscope on a angular motion base with a simple adaptive
filter scheme. Two main topics are highlighted in this work. The first topic is to show building a dual-process model employed
for the conventional Kalman filter. The second topic is to show developing a modified noise adaptive algorithm when measurement
noise and process noise are unknown. The experimental results are presented to show that the simple adaptive filtering scheme
outperforms the other conventional scheme in this paper in terms of noise reduction. 相似文献
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针对舰炮武器系统射击精度低的问题,研究了适宜在炮弹中应用的基于微加速度计的无陀螺捷联惯性制导系统.采用三种方法对载体的角速度进行解算并分析了各种方法的利弊,提供了载体运动参数解算模型,通过仿真计算验证无陀螺方案的可行性,为惯性制导炮弹的发展提供了参考. 相似文献