The role of interleukin-8 produced by tumor induced fibroblasts in the development of cutaneous melanoma

Objective To determine the role of interleukin-8 (IL-8) produced by tumor induced fibroblasts in the development of cutaneous melanoma. Methods B16 melanoma cells induced L929 fibroblasts phenotype was transdifferentiated to myofibroblasts (MF) by co-culture in vitro. MF was monitored by morphology and immunophenotype for a-SMA. The level of IL-8 was detected by ELISA. The effect on B16 cell proliferation rate was estimated using MIT method in vitro. Melanoma implanting model was constructed in C57 mice. Results L929 MF phenotype could be modulated by B16 melanoma cells-derived transforming growth factor-β1 (TGF-β1) and elevated the levels of IL-8. L929 MF did not influence the B16 melanoma cells viability in vitro, but shortened the time of tumor formation and increased the incidence rates of tumors in C57 implanting model mice. Conclusion Fibroblasts can be activated by tumor cells and produce IL-8, which acts as an inflammatory cytokine promoting the development of cutaneous melanoma.     

微电网用有源电力滤波器谐波电流检测新方法

对基于瞬时无功功率理论的ip-iq检测方法进行改进,提出了一种微电网用有源电力滤波器谐波电流检测新方法。通过合理地选择每一级混合形态滤波器结构元素的形状和长度,将多个混合形态滤波器进行串行级联,由此构建链式混合形态滤波器,取代ip-iq检测算法中的低通滤波器以减小检测延时,并用同步参考计算模块替换锁相环以减小检测误差。仿真和实验结果表明,与传统谐波电流检测方法相比,该方法可更快速而准确地检测出谐波信号。     

基于IC卡技术的高安全性门禁系统

研究并设计了一种可联机使用也可单独使用的高安全性的无线IC卡读写模块，它以AT89C51单片机为微控制器，以MFRCS00芯片为IC卡读写器，构建了一个使用简单的IC卡读写系统。该系统基于MFRC500芯片构成读写模块，并对微控制器与读写芯片的通信方式作了详细介绍。该系统的最大特点在于其通信过程中使用高安全性的数据加密算法。     

PIC-MF-based Iterative Receiver for Multiuser Space Frequency Block Coding Systems

A novel low-complexity iterative receiver for multiuser space frequency block coding (SFBC) system was proposed in this paper. Unlike the conventional linear minimum mean square error (MMSE) detector, which requires matrix inversion at each iteration, the soft-in soft-out (SISO) detector is simply a parallel interference cancellation (PIC)-matched filter (MF) operation. The probability density function (PDF) of PIC-MF detector output is approximated as Gaussian, whose variance is calculated with a priori information fed back from the channel decoder. With this approximation, the log likelihood ratios (LLRs) of transmitted bits are under-estimated. Then the LLRs are multiplied by a constant factor to achieve a performance gain. The constant factor is optimized according to extrinsic information transfer (EXIT) chart of the SISO detector. Simulation results show that the proposed iterative receiver can significantly improve the system performance and converge to the matched filter bound (MFB) with low computational complexity at high signal-to-noise ratios (SNRs).     

Environmental effects on Pacejka’s scaling factors

A set of scaling factors has been introduced by Pacejka [Pacejka, H.B., 2002, Tyre and Vehicle Dynamics (Oxford: Butterworth Heinemann Editions)] into his Magic Formula tyre model to take into account the influence of a number of external overall parameters such as road roughness, weather conditions, suspension characteristics and so on. These scaling factors are important for a correct prediction of tyre–road contact forces, but are not a function of the tyre itself. Changing the point of view, one could say that scaling factors should remain constant for different tyres on the same circuit, with the same weather conditions and with the same car. After characterizing different tyres through indoor tests (that do not consider external overall parameters) and after having identified Pacejka’s coefficients with scaling factors equal to one, several outdoor experimental tests have been carried out to assess the influence of vehicle and road surface conditions on scaling factors. These experimental data allowed us to identify, through a minimization approach, the ‘best’ set of Pacejka’s scaling factors for that vehicle and for that tyre on that track. Scaling factors for equal track and vehicle but different tyres were compared to check whether their values remained constant. To access the validity of scaling factors, a comparison between experimental data, collected on an instrumented passenger car, and MB simulations considering unity and identified scaling factors’ values, were carried out. All experimental data shown in this article come from tests carried out within the VERTEC project, a European founded research project (Task 2.a and 2.b) that puts together knowledge coming from vehicle manufacturers (Volvo, Porsche and Centro Ricerche Fiat CRF), tyre manufacturers (Pirelli and Nokian Tyres), control logic manufacturers (Lucas Varity GmbH), road maintenance experts (Centres d’Études Techniques de l’Équipement CETE), transport research organizations (Transport Research Laboratory TRL, Swedish National Road and Transport Research Institute VTI) and universities (Helsinki University of Technology HUT, Politecnico di Milano and University of Florence UNIFI).     

采用中频逆变电阻焊和闪光对焊焊接圆环链的对比研究

文中采用中频逆变电阻焊技术和闪光对焊技术分别焊接大直径高等级圆环链.对比研究了两种焊接工艺过程特点,分析了接头微观组织形貌、断口形貌和接头性能之间的相互关系.结果表明:中频逆变电阻焊技术的编链和焊接工艺过程比闪光对焊生产自动化程度高、生产效率高、生产环境好、焊后无需清除毛刺.在各自最优工艺参数条件下,中频逆变电阻焊对焊圆环链所得接头性能比闪光对焊所得性能好,产品合格率高.