阿尔茨海默病患者性激素水平变化及其意义

目的　探讨阿尔茨海默病 (Alzheimerdisease,AD)患者血清性激素 ,特别是雌激素水平的变化及其意义。方法　AD患者组 2 7例 ,对照组 2 7例 ,采用 1∶1病例 对照研究 ,用放射免疫方法测定两组血清性激素的水平 ,并进行对比分析。结果　血清促卵泡生成素、促黄体生成素、泌乳素、孕酮、睾酮水平在两组间比较没有显著性差异 (P >0 .0 5 ) ;AD组血清雌二醇水平明显低于对照组 ,二组相比有显著性差异 (P <0 .0 5 ) ;血清雌二醇水平与AD患者痴呆的严重程度呈正相关。AD组随着血清雌二醇水平下降 ,MMSE分值亦下降 ,但无相关关系 (r=0 .5 9,P =0 .2 5 )。结论　雌激素水平降低可能是AD发病的危险因素之一

Changes in serum sex hormone level and their significance in Alzheimer''''s disease

Objective To explore the changes in serum sex hormone and their significance in patients with Alzheimer's disease (AD). Methods With 1∶1 pair-matching method the levels of sex hormone in the serum of 27 AD and matched controls were measured by radio-immunosorbent assay. Results There was no significant difference in the level of FSH, LH, PRL, T and P between the two groups (P> 0.05). Estrogen was lower in the patients with AD than in the normal controls and there was a significant difference between the two groups (P< 0.05). The degree of AD was positively correlated with the level of estrogen in AD. Conclusion The lower level of estrogen may be one of the risk factors of AD.