| 肺癌患者外周血T细胞亚群及免疫细胞活性的研究 |
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| 引用本文： | 董西林!第二临床医学院呼吸内科,西安710004,王雅娟!第二临床医学院呼吸内科,西安710004,孙秀珍!第二临床医学院呼吸内科,西安710004,景芬茸!第二临床医学院呼吸内科,西安710004,李家芝!第二临床医学院呼吸内科,西安710004. 肺癌患者外周血T细胞亚群及免疫细胞活性的研究[J]. 西安交通大学学报(医学版), 1999, 0(4) |
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| 作者姓名： | 董西林!第二临床医学院呼吸内科 西安710004 王雅娟!第二临床医学院呼吸内科 西安710004 孙秀珍!第二临床医学院呼吸内科 西安710004 景芬茸!第二临床医学院呼吸内科 西安710004 李家芝!第二临床医学院呼吸内科 西安710004 |
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| 作者单位： | Department of Internal Medicine，Second Affiliated Hospital |
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| 摘 要： | 采用 APAAP法和流式细胞仪研究 32例肺癌患者及 30例健康人外周血T细胞亚群及免疫细胞活性 ( NK- A)的变化。结果表明 :肺癌患者外周血 CD+3 、CD+4、CD+4/CD+8及 NK- A与正常人比较呈显著性降低 ( P <0 .0 5 ,P <0 .0 1 ) ;且肺癌伴癌转移者与未转移者上述各项指标亦有显著性差异 ( P <0 .0 5 )。说明肺癌患者存在细胞免疫功能降低 ;伴有癌转移的肺癌患者细胞免疫功能更低。提出积极调节肺癌患者细胞免疫功能 ,增强机体抗肿瘤能力十分重要。
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| 关 键 词： | 肺肿瘤 T细胞亚群 免疫细胞 天然杀伤细胞 APAAP桥联酶标法 |
STUDY OF T-CELL SUBJECTS AND NK-A IN PERIPHERAL BLOOD OF PATIENTS WITH LUNG CANCER |
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| Dong Xilin,Wang Yajuan,Sun Xiuzhen et al. STUDY OF T-CELL SUBJECTS AND NK-A IN PERIPHERAL BLOOD OF PATIENTS WITH LUNG CANCER[J]. Journal of Xi‘an Jiaotong University:Medical Sciences, 1999, 0(4) |
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| Authors: | Dong Xilin Wang Yajuan Sun Xiuzhen et al |
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| Abstract: | T cell subjects and NK A in peripheral blood were measured by APAAP and Flow Cytometry in 32 patients with lung cancer.The results showed that the proportion of CD - 3,CD + 4 ratio of CD + 4/CD + 8 and NK A decreased significantly (P<0.05 or P<0.01) in comparison with normal control group.In addition, the proportion of CD + 3,CD + 4 ratio of CD + 4/CD + 8 and NK A in lung cancer with metastasis was significantly lower than that of lung cancer with nometastasis (P<0.05).It suggests that the cell immunie function in patients with lung cancer is decreased obviously.So it is important to improve the cell immunie function of patients with lung cancer. |
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| Keywords: | lung tumor T cell subjects immunocyte NK A APAAP |
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