| CHANGES OF ANTIBODIES AGAINST ANTIGENS ENCODED BY DIFFERENT REGIONS OF HCV GENOME IN CHRONIC HEPATITIS C PATIENTS TREATED WITH INTERFERON |
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| 作者姓名： | 蔺淑梅 张树林 狄鹏超 梁雪松 |
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| 作者单位： | Hepatitis Lab，First Clinical Medical College，Xi'an Medical University，Xi'an 710061 |
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| 摘 要： | Interferon(IFN)isthefirstchoicefortreatingchronichepatitisC(CHC),how-ever,onlylO%～25%ofthepatientsshowsustainedresponsetoIFN.ThereisnoreliablemarkertoevaluatetheefficacyofIFNtreatment.Theopinionsonthesig-nificanceofthechangesofantibodiestoantigensencodedbydifferentregionsofHCVgenomeinpatientstreatedwithIFNarecontroversial.Wedevelopedarecom-binantimmunoblotassay(RIBA)includ-ingthreerecombinantantigensofHCV(C22,C33c,Cloo-3),andfollowedup2OchronichepatitisCpatientstreatedwithIFN,to…
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CHANGES OF ANTIBODIES AGAINST ANTIGENS ENCODED BY DIFFERENT REGIONS OF HCV GENOME IN CHRONIC HEPATITIS C PATIENTS TREATED WITH INTERFERON |
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| Lin Shumei, Zhang Shulin, Di Pengchao, Liang Xuesong.CHANGES OF ANTIBODIES AGAINST ANTIGENS ENCODED BY DIFFERENT REGIONS OF HCV GENOME IN CHRONIC HEPATITIS C PATIENTS TREATED WITH INTERFERON[J].Academic Journal of Xi’an Jiaotong University,1997(1). |
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| Authors: | Lin Shumei Zhang Shulin Di Pengchao Liang Xuesong |
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| Abstract: | Twenty patients with chronic hepatitis c were investigated during the treatment with interferon to explore the changes of antibodies to HCV (anti-RCV). Anti-HCV was tested with recombinant immunoblot assay (RIBA) by using three antigens (C22, C33c, and C100-3) encoded by different regions of HCV genome. The changes of individual anti-HCV and ALT were compared with the change of HCV RNA. The results showed that persistent disappearance of serum HCV RNA was closely related to the changes of anti-C33c (P<0. 01) and anti-C100-3 (P<0. 005), but there was no relation between persistent ALT normality and HCV viremia clearance (P<0. 05). In conclusion, monitoring anti-C33c and anti-C100-3 could indicate the changes or HCV viremia. The normalization of ALT after interferon treatment did not indicate disappearance of HCV viremia. |
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| Keywords: | hepatitis C hepatitis C virus ribonucleotide acid (HCV RNA) antibody against HCV (Anti-HCV) recombinant immunoblot assay (RIBA) |
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