雌激素受体、雌激素受体mRNA在胃癌组织中的表达及其意义

目的　研究雌激素受体 (ER)、雌激素受体mRNA在胃癌中的表达 ,以探讨其与胃癌生物学特性的相关性。方法　采用免疫组化和原位杂交技术 ,观察ER、ERmRNA在胃癌组织的表达。结果　①ER阳性率男性为 33.33% ,女性为 46.67% ;ERmRNA阳性率男性为 73.33% ,女性为 86.67% ;②ER阳性以低分化腺癌、印戒细胞癌多见 ;ERmRNA阳性在管状腺癌、低分化腺癌、印戒细胞癌均可见 ;③ER阳性与局部淋巴结转移、生长方式有关 ;④ERmRNA较ER有更高的阳性表达。结论　ERmRNA表达与胃癌生物学特性密切相关 ,可用于胃癌预后判定 ,为胃癌内分泌治疗提供有力的证据

Expression of estrogen receptor and estrogen receptor messenger RNA in gastric carcinoma

Objective　To study estrogen receptor(ER) and estrogen receptor messenger RNA expression in gastric carcinoma and to investigate the relationship with gastric carcinoma biological behaviors.Methods　The expression of ER and ERmRNA in gastric carcinoma were detected by in situ hybridization and immunohistochemistry.Results　①The positive rate of ER in male was 33.33% and in female was 46.67%;The positive rate of ERmRNA in male was 73.33% and in female was 86.67%;②The number of poor-differentiated adenocarcinoma and ring cell carcinoma was more than that of another histologic types in the ER positive cases;ERmRNA was expressed in tubular adenocarcinoma、poor-differentiated adenocarcinoma and ring cell carcinoma;③The ER positive was related to regional lymph nodes metastases and growth pattern;④The positive rate of ERmRNA was higher than that of ER.Conclusion　ERmRNA expression is related to gastric carcinoma biological behaviors,and it might be used to predict the prognosis of gastric carcinoma,and it would provide beneficial evidence to endocrine therapy for gastric carcinoma.