| EXPRESSION OF MATRIX METALLOPROTEINASE-2 AND VASCULAR ENDOTHELIAL GROWTH FACTOR IN HUMAN GLIOMA AND THEIR RELATION TO THE INVASION OF THE TUMOR |
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| 引用本文： | 郭世文 廉民学 李涛 刘守勋 刘森. EXPRESSION OF MATRIX METALLOPROTEINASE-2 AND VASCULAR ENDOTHELIAL GROWTH FACTOR IN HUMAN GLIOMA AND THEIR RELATION TO THE INVASION OF THE TUMOR[J]. 西安交通大学学报(英文版), 2005, 17(2): 145-147 |
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| 作者姓名： | 郭世文 廉民学 李涛 刘守勋 刘森 |
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| 作者单位： | Department of Neurosurgery，First Hospital of Xi'an Jiaotong University，Xi'an 710061，China，Department of Neurosurgery，First Hospital of Xi'an Jiaotong University，Xi'an 710061，China，Department of Neurosurgery，First Hospital of Xi'an Jiaotong University，Xi'an 710061，China，Department of Neurosurgery，First Hospital of Xi'an Jiaotong University，Xi'an 710061，China，Department of Neurosurgery，First Hospital of Xi'an Jiaotong University，Xi'an 710061，China |
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| 摘 要： | Neovascularizationcanbeobservedinthe courseoftumorformationandmalignantinvasion,whichwillpromotethemalignantinvasionofthe tumor[1].Vascularendothelialgrowthfactor(VEGF)andmatrixmetalloproteinases(MMPs)are theimportantadjustiveproteinsintheinvasionand neov…
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| 关 键 词： | 脉管 神经胶质瘤 新血管化 免疫组织化学 |
| 文章编号： | 1671-8267（2005）02-0145-03 |
EXPRESSION OF MATRIX METALLOPROTEINASE-2 AND VASCULAR ENDOTHELIAL GROWTH FACTOR IN HUMAN GLIOMA AND THEIR RELATION TO THE INVASION OF THE TUMOR |
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| Guo ShiWen;Lian MinXue;Li Tao;Liu ShouXun;Liu Sen. EXPRESSION OF MATRIX METALLOPROTEINASE-2 AND VASCULAR ENDOTHELIAL GROWTH FACTOR IN HUMAN GLIOMA AND THEIR RELATION TO THE INVASION OF THE TUMOR[J]. Academic Journal of Xi’an Jiaotong University, 2005, 17(2): 145-147 |
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| Authors: | Guo ShiWen Lian MinXue Li Tao Liu ShouXun Liu Sen |
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| Abstract: | Objective To study the expression of vascular endothelial growth factor (VEGF) and matrix metalloproteinase-2 (MMP-2) in different grade human glioma. To investigate their relation to the pathological grade and invasion of the tumor. Methods The expression of MMP-2 and VEGF were determined by immunohistochemical technique in 48 cases of human glioma and 10 specimens of normal brain tissue. Results The expression levels of MMP-2 and VEGF in human glioma were positively related to tumor grades (P<0.01), and their expressions in the glioma of grade Ⅲ and Ⅳ were significantly different from those in the glioma of grade Ⅰ-Ⅱand normal brain tissue (P<0.01). The expression of MMP-2 was positively correlated to that of VEGF (P<0.01). Conclusion MMP-2 and VEGF were highly expression in human glioma and were positively related to the tumor grades. The synergic interaction of MMP-2 and VEGF promoted the angiogenesis and invasion of human glioma. |
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| Keywords: | glioma matrix metalloproteinases-2 vascular endothelial growth factor invasion |
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