| EFFECT OF SIMULATED WEIGHTLESSNESS ON REPRODUCTION OF ADULT MALE RATS |
| |
| 作者姓名： | 周党侠 邱曙东 王志勇 张洁 |
| |
| 作者单位： | [1]Research Center of Reproductive Medicine, School of Medicine, Xi＇an Jiaotong University [2]Key Laboratory of Environment and Genes Related to Diseases, Ministry of Education, Xi＇an 710061, China |
| |
| 基金项目： | This work was supported by the Scientific Technology Planning Foundation of Shaanxi Province （No. 2005K15-G2）, and the Traditional Medicine Administration Bureau Foundation of Shaanxi Province （No. 2005024） |
| |
| 摘 要： | Objective To study the effects of simulated weightlessness induced by tail-suspension on reproduction in adult male rats and its mechanisms. Methods Twenty Spraque-Dawley adult male rats were randomly divided into two groups： the experimental group and control group. Rats in the experimental group were tail-suspended for 14 days. After the treatment, the weight and morphology of testis, the quantity and quality of sperm, the level of serum testosterone and the apoptusis rate of testicular cells were observed. Results Compared with the control, the testicular weight, the quantity and quality of sperm, the level of serum testosterone significantly decreased （P〈0.05） while the apoptusis rate of testicular calls significantly increased （P〈0.05） in tail-suspended rats. In addition, hematoxylin and eosin （HE） staining showed that seminiferous tubules atrophied, spermatogenic cells decreased, seminiferous epithelial cells disintegrated and shed, and the lumina were azoospermic. Conclusion Simulated weightlessness induced by tail-suspension has a harmful effect on male reproduction of adult rats by increasing the apoptusis of testicular cells.
|
| 关 键 词： | 模拟失重 尾悬浮 老鼠 细胞凋亡 睾丸 |
| 文章编号： | 1671-8267（2006）02-0146-03 |
EFFECT OF SIMULATED WEIGHTLESSNESS ON REPRODUCTION OF ADULT MALE RATS |
| |
| Zhou Dangxia,Qiu Shudong,Wang Zhiyong,Zhang Jie.EFFECT OF SIMULATED WEIGHTLESSNESS ON REPRODUCTION OF ADULT MALE RATS[J].Academic Journal of Xi’an Jiaotong University,2006,18(2):146-148. |
| |
| Authors: | Zhou Dangxia Qiu Shudong Wang Zhiyong Zhang Jie |
| |
| Abstract: | Objective To study the effects of simulated weightlessness induced by tail-suspension on reproduction in adult male rats and its mechanisms. Methods Twenty Spraque-Dawley adult male rats were randomly divided into two groups: the experimental group and control group. Rats in the experimental group were tail-suspended for 14 days. After the treatment, the weight and morphology of testis, the quantity and quality of sperm, the level of serum testosterone and the apoptosis rate of testicular cells were observed. Results Compared with the control, the testicular weight, the quantity and quality of sperm, the level of serum testosterone significantly decreased (P<0.05) while the apoptosis rate of testicular cells significantly increased (P<0.05) in tail-suspended rats. In addition, hematoxylin and eosin (HE) staining showed that seminiferous tubules atrophied, spermatogenic cells decreased, seminiferous epithelial cells disintegrated and shed, and the lumina were azoospermic. Conclusion Simulated weightlessness induced by tail-suspension has a harmful effect on male reproduction of adult rats by increasing the apoptosis of testicular cells. |
| |
| Keywords: | simulated weightlessness tail-suspension rat apoptosis testis |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ |
|
