珍菊降压片对肾性高血压大鼠血压的影响

目的　观察珍菊降压片 (ZJ)及其西药组分对肾性高血压大鼠 (RHR)血压和停药后血压反跳的影响 ,并研究其对RHR血脂与血脂蛋白的影响。方法　左肾动脉狭窄法建立两肾一夹高血压大鼠模型 ;无创尾套法测量清醒RHR尾动脉收缩压。结果　与模型组比较 ,ZJ组 (4 0mg·kg-1,80mg·kg-1,16 0mg·kg-1)及西药组分组 (1.79mg·kg-1,相当于全药中剂量组 )对RHR有明显的降压作用 (P <0 .0 1) ;ZJ各剂量间降压作用无显著性差异 ;同比剂量组(80mg·kg-1)与西药组分组 (1.79mg·kg-1)降压作用无显著性差异 (P >0 .0 5 ) ;与西药组分组 (1.79mg·kg-1)比较 ,ZJ未出现血压反跳现象 (P <0 .0 5 ) ;ZJ对血脂和血脂蛋白无显著性影响 (P >0 .0 5 )。结论　珍菊降压片有良好的抗高血压作用 ,对血脂和血脂蛋白无显著性影响

Effects of ZJ on blood pressure of renovascular hypertensive rats

Objective To observe the effects of ZJ and its chemical components on blood pressure of renal hypertensive rats and to explore its effects on serum triglyceride and lipoprotein. Methods Two-kidney one-clip renal hypertensive rats were obtained by narrowing the left kidney artery;systolic blood pressure of waking RHRs was measured by tail-cuff method. Results The hypotensive effects of ZJ (40 mg·kg -1, 80 mg·kg -1and 160 mg·kg -1) and its chemical components were significant (P<0.01); there was no statistical difference between chemical component group and ZJ of the same dose (80 mg·kg -1) (P>0.05). Compared with chemical component group, blood pressure jerk after withdrawal was not observed (P<0.05). ZJ (40 mg·kg -1, 80 mg·kg -1 and 160 mg·kg -1) had no marked effects on serum triglyceride and lipoprotein. Conclusion ZJ has a satisfactory hypotensive effect and has no marked effects on serum triglyceride and lipoprotein.