| 锰神经毒性的病理生理学研究 |
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| 引用本文： | 吴飞盈,廖海涛,韦义萍,姜岳明.锰神经毒性的病理生理学研究[J].铁道劳动安全卫生与环保,2009,36(6):292-295. |
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| 作者姓名： | 吴飞盈 廖海涛 韦义萍 姜岳明 |
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| 作者单位： | 1. 广西医科大学护理学院,广西,南宁,530021
2. 广西医科大学公共卫生学院,广西,南宁,530021 |
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| 基金项目： | 国家自然科学基金项目，广西自然科学基金，广西教育厅研究生教育创新计划 |
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| 摘 要： | 慢性锰暴露可能引起多巴胺能功能选择性障碍、谷氨酸能运输系统受损、活性氧产生、＂外周型＂苯二氮卓类受体结合位点增加、参与糖分解的三磷酸甘油醛脱氢酶及其它酶类代谢异常,导致能量代谢变化、细胞形态改变、神经元损伤及细胞外谷氨酸浓度增加,这对于从病理生理学角度阐明锰神经毒性机制具有十分重要的作用。
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| 关 键 词： | 锰 神经毒性 病理生理学 |
Pathophysiologic study of Manganese Neurotoxicity |
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| WU Fei-ying,LIAO Hai-tao,WEI Yi-ping,JIANG Yue-ming.Pathophysiologic study of Manganese Neurotoxicity[J].Railway Occupational Safety Health & Environmental Protection,2009,36(6):292-295. |
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| Authors: | WU Fei-ying LIAO Hai-tao WEI Yi-ping JIANG Yue-ming |
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| Institution: | WU Fei-ying , LIAO Hai-tao , WEI Yi-ping , JIANG Yue-ming ( 1. Nursing College, Guangxi Medical University, Nanning 530021, China ; 2. School of Public Health, Guangxi Medical University, Nanning 530021, China ) |
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| Abstract: | Chronic exposure to manganese causes selective dopaminergic dysfunction,impairment of glutamate transport,production of active oxygen,increased densities of binding sites for the ＂peripheral-type＂ benzodiazepine receptor,alterations of the glycolytic enzyme glyceraldehyde-3-phosphate dehydrogenase and abnormal metabolism of other enzymes.Such effects can lead to changed energy metabolism,altered cellular morphology,damaged neurons and increased extracellular glutamate concentration.It plays a very important role to clarify the pathophysiologic mechanism of manganese neuroxicity. |
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| Keywords: | manganese neurotoxicity pathophysiology |
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