涎腺腺样囊性癌的免疫组化研究

利用3种抗体对15例涎腺腺样囊性癌(其中6例含有正常涎腺),进行了免疫组化研究。结果发现:正常涎腺的肌上皮细胞呈S-100蛋白阳性;纹管和排泄管的基底细胞呈角蛋白强阳性。在腺样囊性癌中发现,筛孔状假囊的衬里细胞、细胞巢的外周细胞、小管状结构的外层细胞和小梁边缘细胞呈S-100蛋白、波形蛋白阳性,有时呈角蛋白阳性。而小管的内层细胞和小梁中央细胞呈角蛋白阳性。以上发现提示,腺样囊性癌可能来源于正常涎腺纹管和排泄管的基底细胞。

AN IMMUNOHISTOCHEMICAL STUDY OF ADENOID CYSTIC CARCINOMA OF THE SALIVARY GLANDS

Three antibodies were used for immunohistochemical study of 15 cases of adenoid cystic carcinoma(6 cases contained normal salivary gland tissue). The results indicated that myoepithelial cell of the normal salivary glands revealed positive reaction of S-100 protein; The basal cells of the straited ducts and excretary ducts revcaled strong positive reaction of keratin. In adenoid cystic carcinoma positive reaction of S-100 prctein and vimentin were found in luminal cells of cribriform pseudocyts and peripheral cells of tumor nests, and the outer layers'cells of tubular stucture and the border cells of trabucula. But the positive reaction of keratin was found in inner cells of tubular and central cells of trabecular patten. It indicated that adenoid cystic carcinoma probably stems from the basic cells of the striated ducts and excretary ducts of normal salivary glands.