| 激活多巴胺受体对大鼠脊髓背角Fos样蛋白生成的抑制作用 |
| |
| 引用本文： | 吕韶岗,梅俊,纪亚平.激活多巴胺受体对大鼠脊髓背角Fos样蛋白生成的抑制作用[J].西安交通大学学报(医学版),1997(3). |
| |
| 作者姓名： | 吕韶岗 梅俊 纪亚平 |
| |
| 作者单位： | 西安生理学教研室!西安，710061，西安生理学教研室!西安，710061，西安生理学教研室!西安，710061 |
| |
| 摘 要： | 以免疫细胞化学ABC法，观察多巴胺受体激动剂和桔抗剂对伤害性电刺激大鼠单侧后爪诱发的同侧腰段脊髓背角Fos阳性神经元的影响。发现伤害性电刺激诱发的Fos阳性神经元，多数位于同侧背角浅层，排列密集，少数位于同侧背角深层，排列稀疏；腹腔注射多巴胺受体激动剂使同侧背角浅层和深层的Fos阳性神经元显著减少，而多巴胺二型受体拮抗剂能够完全阻断多巴胺受体激动剂的抑制作用。提示多巴胺受体参与脊髓水平伤害性信息传递的调控。
|
| 关 键 词： | Fos样免疫反应活性 脊髓背角 DA受体 伤害性感受 |
INHIBITING ACTION OF ACTIVATION OF DA RECEPTORS ON INDUCTION OF FOS-LIKE PROTEIN IN RAT LUMBAR SPINAL CORD |
| |
| Lu Shaogang, Mei Jun, Ji Yaping.INHIBITING ACTION OF ACTIVATION OF DA RECEPTORS ON INDUCTION OF FOS-LIKE PROTEIN IN RAT LUMBAR SPINAL CORD[J].Journal of Xi‘an Jiaotong University:Medical Sciences,1997(3). |
| |
| Authors: | Lu Shaogang Mei Jun Ji Yaping |
| |
| Institution: | Depariment of Brain and Nerve |
| |
| Abstract: | In the present experiment we used immunocytochemical labeling for the Fos-like pro-tein to determine the location of lumbar spinal cord nociresponsive neurons that are inhibited by activa-tion of the DA receptors. Electrical stimulation ap-plied to the unilateral hindpaw evoked numerous Fos-like immunoreactivity in the ipsilateral superfi-cial and deep laminae of the lumbar spinal cord. DA receptor agonist injected intraperitoneally reduced significantly Fos-like immunoreactivity in these re-gions, and this effect was blocked by D2 receptor an-tagonist completely. These data demonstrate that DA receptors are involved in the modulation of transmission of nociceptive in formation at spinal lev-el. |
| |
| Keywords: | Fos-like immunoreactivity spinal cord dorsal horn DA receptor nociception |
| 本文献已被 CNKI 等数据库收录！ |
