| 沙棘总黄酮对培养心肌细胞搏动及电活动的影响 |
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| 引用本文： | 吴捷,李孝光.沙棘总黄酮对培养心肌细胞搏动及电活动的影响[J].西安交通大学学报(医学版),1990(4). |
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| 作者姓名： | 吴捷 李孝光 |
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| 作者单位： | 西安医科大学电生理学研究室
(吴捷)，西安医科大学电生理学研究室(李孝光) |
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| 摘 要： | 本实验研究了TFH对培养乳鼠心肌细胞的跨膜电活动及搏动的影响。结果表明:TFH可使细胞搏动频率显著降低,搏动幅度下降,细胞动作电位复极50%和90%的时程(APD_(50)APD_(90))缩短,4相去极化斜率下降,其它参数未见显著变化。此外还观察到TFH可使异常自发搏动节律转为有规律的搏动。提示TFH对培养心肌细胞的作用机制可能与抑制Ca~(2+)跨膜转运和促K~+外流有关。
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| 关 键 词： | 沙棘总黄酮 培养心肌细胞 动作电位 细胞搏动 |
THE EFFECT OF TOTAL FLAVONES OF HIPPOPHAE RHAMNOIDES L. ON BEATING AND ELECTRICAL ACTIVITY OF CULTURED CARDIAC CELL |
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| Wu Jie,Li Xiaoguang.THE EFFECT OF TOTAL FLAVONES OF HIPPOPHAE RHAMNOIDES L. ON BEATING AND ELECTRICAL ACTIVITY OF CULTURED CARDIAC CELL[J].Journal of Xi‘an Jiaotong University:Medical Sciences,1990(4). |
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| Authors: | Wu Jie Li Xiaoguang |
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| Institution: | Research Lab oratory of Electrophysiology |
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| Abstract: | In this paper, we studied the effect of total flavones of Hippophae rhamnoides L (TFH) on beating and transmembrane potential of cultured sucking rat cardiac cell. The results indicated that cellular beating rate and beating amplitude were significantly reduced, the action potential duration of 50% and 90% repolarization was sbortened, the slope of phase 4 depolarization was decreased, and other parameters of the action potential showed no significant change. In addition, we also observed that TFH could make the spontaneous abnormal beating of cell change into regular beating. These findings suggested that the mechanism of TFH on cultured cardiac cell might have some relation to antagonizing inward flow of Ca~(2+) and aocelerating the move of k' outward. |
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| Keywords: | TFH culturcd card ac cell action potential cellular beating |
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