谷氨酰胺对肝硬化大鼠肠粘膜的保护作用

采用四氯化碳致大鼠肝硬化模型，观察口服谷氨酰胺对肝硬化大鼠肝功、死亡率及空肠粘膜谷胱甘肽含量的影响，并对空、回肠粘膜进行了组织形态学观察。结果表明，谷氨酰胺对肝硬化大鼠肝功、死亡率无明显影响。与模型对照组相比，谷氨酰胺治疗组空肠粘膜谷胱甘肽含量及空、回肠粘膜厚度、绒毛高度显著增加（ Ｐ＜００５），且上述指标与正常组比较差异无显著性。表明补充外源性谷氨酰胺可明显减轻肝硬化时肠粘膜损伤，增加空肠粘膜谷胱甘肽含量。提示谷氨酰胺可用于预防肝硬化时与肠粘膜损伤有关的各种并发症的发生

PREVENTION EFFECT OF GLUTAMINE ON GUT MUCOSA OF CARBON TETRACHLORIDE-INDUCED CIRRHOSIS RATS

To determine whether glutamine supplement could repair the disrupted gut mucosal barrier of cirrhosis, rats with carbon tetrachloride induced cirrhosis were used.Then rats were killed and studied for serum TP,ALT,albudmin concentration, mortality rate, and glutathione content of gut mucosa.Morphology of jejunum and ileum mucosa was analyzed simultaneously.Results of present study showed,to compair with the cirrhosis control group,glutamine enriched diets to rats resulted villus height of intestinc and mucosal thickness of intestine(P<0.05).Cirrhosis rats with glutamine supplement were similar to the normal rats at intestinal morphology and glutathione content in jejunum mucosa.Glutamine supplement did not influence serum TP,ALT, albumin concentration and mortality rate.It is suggested that glutamine supplentation can reverse small bowel disruption and restore glutathione content in jejunum mucosa in rats with cirrhosis.It indicated that glutamine supplentation can be used to prevent some complications of cirrhosis that related to disruption of gut mucosal barrier.