帕金森病筛查量表效度及其分值分布特征分析

目的　研究PD筛查量表分值在老年人群中的分布特征及筛查帕金森病的效度。方法　以PD筛查量表为筛查工具 ,采用多级分层随机整群抽样的方法 ,筛查西安地区 5 5岁及以上老年人群中帕金森病患者 ,计算PD筛查量表分值的百分位数与均值和年龄、性别分布及不同分界值筛查PD的特异度、灵敏度及预测值。结果　共完成PD筛查量表 4844人 ;PD筛查量表的分值在 5 5岁及以上老年人群中呈明显偏态分布 ,其偏度系数为 5 .44± 0 .0 4 ,峰度系数为 34.86± 0 .0 7;男女各年龄组PD筛查量表分值的中位数均为零 ;性别、年龄对PD筛查量表的分值均有影响 (P <0 .0 1 ) ,随着年龄增大 ,PD筛查量表分值的均值逐渐升高 ;以分界值 >1时 ,灵敏度及特异度均较高 ( 89.5 % ,99.5 % )。结论　在老年人群中进行帕金森病的流行病学调查时 ,PD筛查量表是较为有效的筛查工具 ,取分界值 >1为较合适的筛查分界值。PD筛查量表筛查的结果不能取代临床诊断

The distribution and validity of PD screening instrument scores

Objective To study the distribution of the PD screening instrument (PDSI) scores and screening validity in Xi'an Chinese residents aged 55 years and over. Methods A total of 4850 residents aged 55 and over were drawn by means of stratified multistage cluster sampling from the population of Xi'an and PDSI was used as a tool. The summary scores for PDSI were given in the form of mean percentage distributions specific for age and sex to calculate the validity of the PDSI by using different cutoff scores. Results The 4844 residents completed PDSI; The distribution for PDSI in the residents aged 55 and over was displayed by skewness distribution. Its skewness coefficient and kureosis coefficient were 5.44±0.04 and 34.86±0.07, respectively. We found a bivariate correlation between the PDSI scores and all the two factors of sex and age ( P < 0.01 ). The mean of PDSI increased with age; the sensitivity (89.5%) and specificity (99.5%) were higher if the cutoff score was higher than 1. Conclusion PDSI is an effective screening instrument for studying the prevalence of Parkinson's disease in the old population. The cutoff score higher than 1 is better; however, PDSI scores cannot be used to make formal clinical diagnosis.