| 硫酸亚铁对豚鼠离体心房肌负性肌力作用 |
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| 引用本文： | 马欣,于力,罗光伟,李孝光. 硫酸亚铁对豚鼠离体心房肌负性肌力作用[J]. 西安交通大学学报(医学版), 1993, 0(1) |
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| 作者姓名： | 马欣 于力 罗光伟 李孝光 |
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| 作者单位： | 西安医科大学药理学教研室，西安电子科技大学应用数学系，西安医科大学药理学教研室，西安医科大学药理学教研室 西安 710061，西安 710071，西安 710061，西安 710061 |
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| 摘 要： | 用豚鼠离体心房肌标本研究了FeSO_4对其生理特性影响。FeSO_4 0.2mmol/L使心房肌收缩力由对照的100%下降到67±9%,增加引起心房自律性的肾上腺素浓度,并使时间—强度曲线右移。功能不应期从298±26ms延长至402±43ms。负性肌力作用和对自律性的抑制表明FeSO_4可影响Ca~(2+)转运,而抑制兴奋性及延长功能不应期提示它可能抑制Na~+内流。
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| 关 键 词： | 心房肌 硫酸亚铁 收缩性 |
NEGATIVE INOTROPISM OF THE EFFECT OF FeSO_4 ON ISOLATED GUINEA PIG HEART ATRIUM |
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| Ma Xin,Yu Li,Luo Guangwei,et al. NEGATIVE INOTROPISM OF THE EFFECT OF FeSO_4 ON ISOLATED GUINEA PIG HEART ATRIUM[J]. Journal of Xi‘an Jiaotong University:Medical Sciences, 1993, 0(1) |
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| Authors: | Ma Xin Yu Li Luo Guangwei et al |
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| Affiliation: | Ma Xin,Yu Li,Luo Guangwei,et al Department of Pharmacology |
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| Abstract: | The effects of FeSO_4 upon the physiologicproperties were studied with isolated guinea pig a-trium. The FeSO_4 0. 2mmol/L, makes the contrac-tility of the atrium muscle decrease from 100% ofcontrol to 67 ± 9%. The concentration ofepinephrine inducing automaticity increased andthe duration-intensity curve was shifted to theright. The functional refractory period (FRP) wasprolonged from 298 ± 26 ms to 402 ± 43 ms. Thenegative inotropism and the inhibition of the auto-maticity suggest that FeSO_4 may influence Ca~(2+)movement, while the excitability of suppressionand prolongation of FRP indicate that it may bedue to its inhibition of Na~+ influx. |
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| Keywords: | heart atrium FeSO_4 contractility |
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