PROTECTIVE EFFECTS OF LIGUSTRAZINE ON ISCHEMIA-REPERFUSION INJURY IN RAT KIDNEYS |
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Authors: | Sun Lijiang,Li Yujun,Shi JingsenHepato-biliary Research Laboratory,First Hospital of Xi'an Jiaotong Univerisity,Xi'an ,China. " |
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Affiliation: | 1. Hepato-biliary Research Laboratory, First Hospital of Xi'an Jiao tong Univerisity, Xi'an 710061, China. 2. Department of Pathology, Affiliated Hospital of Medical College, Qingdao Uni versity, China. |
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Abstract: | Objective To investigate the protective effects of Ligustrazine on ischemia-reperfusion injury in rat kidneys.Methods Influence of Ligustrazine for injection on the changes of plasma superoxide dismutase(SOD), malondialdehyde (MDA) and endothelin-1 (ET-1) as well as the morphology of injured tubule was observed after ischemia-reperfusion injury of rat kidneys.Results In Ligustrazine group, the levels of plasma SOD were significantly higher, but the levels of plasma MDA and ET-1 and the pathological grading of injured renal tubule were significantly lower than those in control group (P<0.05).Conclusion Ligustrazine has a protective effect on rat kidneys with ischemia-reperfusion injury. |
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Keywords: | kidney ischemia-reperfusion |
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