APOPTOSIS OF HYPERPLASIA AND CANCER OF THE GALLBLADDER WITH CALCULAS

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APOPTOSIS OF HYPERPLASIA AND CANCER OF THE GALLBLADDER WITH CALCULAS

Objective To investigate the relation between different extent of proliferation caused by gallstone and gallbladder cancer by counting the proliferation and the apoptosis of the gallbladder cancer for the clinically prevention of the gallbladder carcinoma.Methods The TUNEL method was used to detect the apoptosis of the specimens and the mean apoptosis indices obtained by quantification of apoptosis cells fluorescence by laser scanning confocal microscope were compared among the variable pathological patterns.Results The mean apoptosis indexes in the mormal and abnormal specimens with cholecystitis,simple hyperplasia, low-grade dysplasia, mid-grade dysplasia, high-grade dysplasia and carcinoma were 5.11, 5.49, 6.32, 8.65, 12.27, 25.24, 39.62, 119.8, respectively. There was significant difference among the variable pathological patterns and as the lesion progressing, the index went up gradually with the carcinoma had the highest index. Conclusion The apoptosis indexes increase with the pathological progress during the carcinogenesis of gallbladder cancer caused by lithiasis, which stimulate the epithelium for long time and result in an increasing of the apoptosis; and it may play an important role in the carcinogenesis of gallbladder cancer.